DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35A1 and ugt-39

DIOPT Version :9

Sequence 1:	NP_524314.2	Gene:	Ugt35A1 / 41334	FlyBaseID:	FBgn0026315	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_504816.2	Gene:	ugt-39 / 3564933	WormBaseID:	WBGene00017329	Length:	523	Species:	Caenorhabditis elegans

Alignment Length:	535	Identity:	126/535 - (23%)
Similarity:	227/535 - (42%)	Gaps:	47/535 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 LIGLIWLFAANADEGVQSSRILAVFPFPGRSQYIFAEQFMKELAHRGHNVTVI---------NTF 69
            |:.:::||..|    |.|...|...|....|...|.......|...|||||..         |..
Worm     3 LLFILFLFFGN----VSSFNFLVFCPLFAHSHSKFFATIADSLTDAGHNVTFFTPTIVEKYRNVS 63

  Fly    70 GSDKNEPNFRVIGAKKIHEIMAAFGNADY----TQTASQWQMLTMTTQFLNLLT---TSILDDAA 127
            .:...:....:..:||:.|........|:    |:.::..:::.:...|..:..   |.:.|:..
Worm    64 YTKSTKDVVHMKPSKKLKEYGEQMSTGDFVRYWTEDSTATEIIPVVRIFQKMYNEQGTVMKDNVG 128

  Fly   128 VKDLLNSGEKFDLVIMEAVQTEALFGLIQHFGAET-IGISSYGTDTHIDELMGNISPLSYNPLLL 191
            :.:.|.. .|||::|.||....| :.|:.:....| |...|...||.:...:|.....|.....|
Worm   129 ILNELKK-RKFDVIIFEAYIYSA-YPLMDYLEIPTFIPSVSVAHDTSLAIEIGEPVMPSVVSDCL 191

  Fly   192 SSRTEQMDFKDRVMNVFEASVMWLHKRIVHLPSQRDLYAKYFPTARKSLDEVLDSFALMLLGQHF 256
            |...:::...:|..|.|   ::.....::..|:.|.....|.|...:|   ::...:.:.|..:.
Worm   192 SPFGDKLSITERAFNAF---MVPYFDFMIGYPTHRSFKPPYNPIDIRS---IVPEASFVFLNSNP 250

  Fly   257 SLSYPRPYLPNMIEVGGLHLQQKR-KVQPLAKELSEFVEQSEKGVIYFSMGSNIKSKDLPPSTR- 319
            .:.:|||.|...|::||:.:.... :.|.|.:..||.::..||.:: .|.||.:.|||:|...:
Worm   251 FVDFPRPTLTKTIQIGGISVDSNELRSQKLDETWSEILKLREKTML-VSFGSMLYSKDMPFKNKI 314

  Fly   320 --KMLMQTFASVPQRVLWKFEDDQLPEKP---DNVFISKWFPQPDILAHPNVKLFITHGGLLSTI 379
              |..|:.|.:|  ..:||:|||...|..   :|:..:||.||..:||...:..|:||.||.|..
Worm   315 ALKNAMEKFKNV--TFIWKYEDDSSDEFAKGIENIHFAKWVPQTALLADSRLSAFLTHAGLGSIN 377

  Fly   380 ESIYFGKPILGLPIFYDQHLNVQRAKQVGYGLSADIWSVNATE-LTPLIQELLSNPSYAAAAQTK 443
            |..|.|||.:..|..:||..|.:...:....:....:.:..:| :....|.:|.:.|||..|...
Worm   378 ELSYLGKPAILCPQLFDQMRNAKMLVRHNGSIELSKYDLGDSEKIVNAFQAILFDSSYAKNALKL 442

  Fly   444 SKLFRDQKETALERAIWWTEYVLRHKGAKHLRCASRDLDFIQFHGLDTWGLLIAITFVSLLIVVI 508
            ::...:|.....|..:...|:..|......|...||.:.||::       .||.:..:|:::::.
Worm   443 AEQLENQPIKPKEMMVKHAEFAARFGRLPSLDPYSRKMTFIEY-------FLIDVAAISMVVLIA 500

  Fly   509 LIKCLQRVFVSLISK 523
            ::..:.::|..|.:|
Worm   501 VVFVITKMFKILCNK 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35A1	NP_524314.2	egt	19..474	CDD:223071	114/479 (24%)
Ugt35A1	NP_524314.2	UDPGT	55..526	CDD:278624	116/494 (23%)
ugt-39	NP_504816.2	Glycosyltransferase_GTB_type	12..503	CDD:299143	120/512 (23%)
ugt-39	NP_504816.2	UDPGT	29..521	CDD:278624	118/505 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.810