DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35A1 and Ugt2b37

DIOPT Version :9

Sequence 1:	NP_524314.2	Gene:	Ugt35A1 / 41334	FlyBaseID:	FBgn0026315	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_001007265.4	Gene:	Ugt2b37 / 29623	RGDID:	3937	Length:	530	Species:	Rattus norvegicus

Alignment Length:	557	Identity:	164/557 - (29%)
Similarity:	274/557 - (49%)	Gaps:	76/557 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 WLFA---ANADEGVQSSRILAVFPFPGR-SQYIFAEQFMKELAHRGHNVTVINTFGSDKNEPN-F 78
            |:||   ......::|::...|..:|.. |.::..:..:.||..|||.|||:        :|: :
  Rat     5 WIFALLLLQISFCLRSAKCGKVLVWPMEFSHWMNIKTILDELVQRGHEVTVL--------KPSAY 61

  Fly    79 RVIGAKKIHEI-MAAFGNA--------DYTQTASQW--QMLTMTTQFLNLLTTSILDD------A 126
            .|:..||..:: ...|..:        .:.:....|  ::...|....:.|..:::|:      :
  Rat    62 YVLDPKKSPDLKFETFPTSVSKDELEKYFIKLVDAWTYELQRDTCLSFSPLLQNMMDEFSDYYLS 126

  Fly   127 AVKDLLNSGE--------KFDLVIMEAVQTEALFGLIQHFGAETIGI----SSYGTDTH-IDELM 178
            ..||.:::.:        |||:::.:.|  .|...||    ||.:.|    |...:..| |::..
  Rat   127 VCKDAVSNKQLMAKLQESKFDVLLSDPV--AACGELI----AEVLHIPFLYSLRASPGHKIEKSS 185

  Fly   179 GN-ISPLSYNPLLLSSRTEQMDFKDRVMNV-----FEASVMWLHKRIVHLPSQRDLYAKYF--PT 235
            |. |.|.||.|::||....||.|.|||.|:     |:   .|.|  :.:..:....|.:..  ||
  Rat   186 GRFILPPSYVPVILSGLGGQMTFIDRVKNMICMLYFD---FWFH--MFNAKNWDPFYTEILGRPT 245

  Fly   236 ARKSLDEVLDSFALMLLGQHFSLSYPRPYLPNMIEVGGLHLQQKRKVQPLAKELSEFVEQS-EKG 299
               :|.|.:....:.|:..::.|.:|.|.|||:..:|||   |.:..:||.|::.:||:.| |.|
  Rat   246 ---TLAETMGKAEMWLIRSYWDLEFPHPTLPNVDYIGGL---QCKPAKPLPKDIEDFVQSSGEHG 304

  Fly   300 VIYFSMGSNIKSKDLPPSTRKMLMQTFASVPQRVLWKFEDDQLPEK-PDNVFISKWFPQPDILAH 363
            |:.||:||.:.|  :.......:....|.:||:||||| |.::|.. ..|..:.||.||.|:|.|
  Rat   305 VVVFSLGSMVSS--MTEEKANAVAWALAQIPQKVLWKF-DGKIPATLGPNTRVYKWLPQNDLLGH 366

  Fly   364 PNVKLFITHGGLLSTIESIYFGKPILGLPIFYDQHLNVQRAKQVGYGLSADIWSVNATELTPLIQ 428
            |..|.|:||||.....|:||.|.|::|:|:|.:||.|:......|..::.:|.:::.::|...::
  Rat   367 PKTKAFVTHGGANGVYEAIYHGIPMIGIPMFGEQHDNIAHMVAKGAAVTLNIRTMSKSDLFNALK 431

  Fly   429 ELLSNPSYAAAAQTKSKLFRDQKETALERAIWWTEYVLRHKGAKHLRCASRDLDFIQFHGLDTWG 493
            |:::||.|...|...|.:..||....|::||:|.|||:|||.|||||....:|.:.|:|.||..|
  Rat   432 EVINNPFYKKNAMWLSTIHHDQPMKPLDKAIFWIEYVMRHKRAKHLRPLGHNLPWYQYHSLDVIG 496

  Fly   494 LLIAITFVSLLIVVILIKCLQRVFVSLISKIRKNRAE 530
            .|:|...|   |..:.:||...::.....|.:|.:.|
  Rat   497 FLLACLAV---IAALAVKCFLFIYRFFAKKQKKMKNE 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35A1	NP_524314.2	egt	19..474	CDD:223071	146/499 (29%)
Ugt35A1	NP_524314.2	UDPGT	55..526	CDD:278624	155/511 (30%)
Ugt2b37	NP_001007265.4	UDPGT	24..527	CDD:278624	158/533 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	256	1.000	Domainoid score	I1959
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2882
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm9018
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.760