DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35A1 and Ugt2a3

DIOPT Version :9

Sequence 1:	NP_524314.2	Gene:	Ugt35A1 / 41334	FlyBaseID:	FBgn0026315	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_001129341.1	Gene:	Ugt2a3 / 289533	RGDID:	1308444	Length:	534	Species:	Rattus norvegicus

Alignment Length:	562	Identity:	168/562 - (29%)
Similarity:	278/562 - (49%)	Gaps:	73/562 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LGILLIGLIWLFAANADEGVQSSRILAVFPFPGRSQYIFAEQFMKELAHRGHNVTVIN----TFG 70
            :.|.|:.|.|     :..|: .|::| |:|. ..|.::..:..::|||.|||.|||:.    ...
  Rat     8 VAIFLLQLCW-----SGCGI-CSKVL-VWPC-DMSHWLNLKTILEELAARGHEVTVLKYPSIIID 64

  Fly    71 SDKNEP----NFRV-----IGAKKIHEIMAAFGNADYTQTASQWQ--------MLTMTTQFLNLL 118
            ..|..|    |..|     :....::||:....|.  ....|.|:        .|.:|..|.:|.
  Rat    65 QSKLTPLQFENIPVLYETEVAENHLNEIVNLAVNV--IPNLSLWEAARTLQDFFLQLTGNFEDLC 127

  Fly   119 TTSILDDAAVKDLLNSGEKFDLVIMEAVQT--EALFGLIQHFGAETIGIS-SYGTDTHIDELMGN 180
            .:::.:...:..|.::  |:|:::::.|..  |.:..::|.....|:..| .|..:.:..:|.
  Rat   128 RSTLYNQTLMNKLRDA--KYDVMVLDPVIPCGELVAEVLQIPFVNTLRFSMGYSMEKYCGQLP-- 188

  Fly   181 ISPLSYNPLLLSSRTEQMDFKDRVMNV-----FEASVMWLHKRIVHLPSQRDLYAKYF--PTARK 238
             .||||.|:::...|:.|.|.:||.|:     ||   .||.:.......|  .|:|..  ||
  Rat   189 -VPLSYVPVVMGELTDHMTFTERVKNMMLSLFFE---FWLQQYDFAFWDQ--FYSKTLGRPT--- 244

  Fly   239 SLDEVLDSFALMLLGQHFSLSYPRPYLPNMIEVGGLHLQQKRKVQPLAKELSEFVEQS-EKGVIY 302
            :..:.:....:.|:..::.:.:|||||||...|||||.   :..:||.|||.|||:.| |.||:.
  Rat   245 TFCKTVGKAEIWLIRTYWDIEFPRPYLPNFEFVGGLHC---KPAKPLPKELEEFVQSSGEHGVVV 306

  Fly   303 FSMGSNIKSKDLPPSTRKMLMQTFASVPQRVLWKFEDDQLPEKPDNVFISKWFPQPDILAHPNVK 367
            ||:||.|  |:|......::....|.:||:|||::...:......|..|..|.||.|:|.||..:
  Rat   307 FSLGSMI--KNLTEEKANLIASALAQIPQKVLWRYSGKKPATLGPNTRILNWIPQNDLLGHPKTR 369

  Fly   368 LFITHGGLLSTIESIYFGKPILGLPIFYDQHLNVQRAKQVGYGLSADIWSVNATELTPLIQELLS 432
            .||||||.....|:||.|.|::|:|:|.||..|:...:..|..:...|.::.:.:|...::.:::
  Rat   370 AFITHGGTNGIYEAIYHGVPMVGIPMFGDQPYNIAHMEAKGAAVKVAINTMTSADLLSALRAVIN 434

  Fly   433 NPSYAAAAQTKSKLFRDQKETALERAIWWTEYVLRHKGAKHLRCASRDLDFIQFHGLDTWGLL-- 495
            .|||...|...|::..||....|:||::|.|:|:|||||||||.|:.||.:.|:|.||..|.|
  Rat   435 EPSYKENAMRLSRVHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHDLSWFQYHSLDVIGFLLV 499

  Fly   496 --IAITFVSLLIVVILIKCLQRVFVSLISKIRKNRAEASKLK 535
              :.:|||       :.||  .:|:.....:|:.:.:.::.|
  Rat   500 CVVTLTFV-------ITKC--SLFMCRKCCLRERKKKGNRKK 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35A1	NP_524314.2	egt	19..474	CDD:223071	145/486 (30%)
Ugt35A1	NP_524314.2	UDPGT	55..526	CDD:278624	156/506 (31%)
Ugt2a3	NP_001129341.1	UDPGT	25..519	CDD:278624	160/524 (31%)
Ugt2a3	NP_001129341.1	egt	<268..506	CDD:223071	96/242 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166344014
Domainoid	1	1.000	256	1.000	Domainoid score	I1959
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55988
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2882
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm9018
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.790