DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35A1 and Ugt2b35

DIOPT Version :9

Sequence 1:	NP_524314.2	Gene:	Ugt35A1 / 41334	FlyBaseID:	FBgn0026315	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_766469.1	Gene:	Ugt2b35 / 243085	MGIID:	3576100	Length:	529	Species:	Mus musculus

Alignment Length:	518	Identity:	152/518 - (29%)
Similarity:	255/518 - (49%)	Gaps:	53/518 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 SQYIFAEQFMKELAHRGHNVTVINTFGSDKNEPNFRVIGAKKIHEIMAAFGNADYTQT-----AS 103
            |.::..:..:.||..|||.|||:....|...:|.:.  ...|......|| :.||.:|     ..
Mouse    34 SHWMNLKIILDELVQRGHEVTVLRPSASIFVDPKYS--PGLKFETFPTAF-SKDYLETFLTKLVD 95

  Fly   104 QW--QMLTMTTQFLNLLTT----------SILDDA-AVKDLLNSGE--KFDLVIMEAVQT--EAL 151
            :|  ::...|....:||.|          |:..:| :.|.|:...:  |||::|::|:.:  |.:
Mouse    96 EWTFEVPRDTCLSYSLLQTLFGKLSDYSLSLCKEAVSNKQLMTKFQESKFDVLILDAMASCGELI 160

  Fly   152 FGLIQHFGAETIGIS-SYGTDTHIDELMGNISPLSYNPLLLSSRTEQMDFKDRVMNV-----FEA 210
            ..|:|.....::..| .|..:.:..   |.:.|.||.|::||....||.|.:||.|:     |:
Mouse   161 AQLLQIPFLYSLRFSPGYQVEKNSG---GFVLPPSYVPVILSGLGGQMTFTERVKNMICMLYFD- 221

  Fly   211 SVMWLHKRIVHLPSQRDLYAKYFPTARK--SLDEVLDSFALMLLGQHFSLSYPRPYLPNMIEVGG 273
              .|....     ::::....|..|..:  :|.|.:....:..:..::.|.:|.|.|||:..|||
Mouse   222 --FWFQTF-----TEKEWDQFYSETLGRPTTLIETMGKAEMWFIRSYWDLEFPHPTLPNVEYVGG 279

  Fly   274 LHLQQKRKVQPLAKELSEFVEQS-EKGVIYFSMGSNIKSKDLPPSTRKMLMQTFASVPQRVLWKF 337
            ||.   :..:||.||:.:||:.| ..||:.||:||.:  .::.......:....|.:||:|||:|
Mouse   280 LHC---KPAKPLPKEMEDFVQSSGVHGVVVFSLGSMV--SNMTEERANAISWALAQIPQKVLWRF 339

  Fly   338 EDDQLPEKPDNVFISKWFPQPDILAHPNVKLFITHGGLLSTIESIYFGKPILGLPIFYDQHLNVQ 402
            :.........|..|.||.||.|:|.||..|.|:||||.....|:|:.|.|::|:|:|.:||.|:.
Mouse   340 DGKTPASLGPNTRIYKWLPQNDLLGHPKTKAFVTHGGANGLYEAIHHGIPMIGIPLFSEQHDNIA 404

  Fly   403 RAKQVGYGLSADIWSVNATELTPLIQELLSNPSYAAAAQTKSKLFRDQKETALERAIWWTEYVLR 467
            .....|..::.:|.:::.::|...::|:::||||.......|.:..||....|.|.|:|.|:|:|
Mouse   405 HMVAKGTAVALNIRTMSRSDLLNALEEVINNPSYKENVMWLSTIHHDQPMKPLNRTIFWIEFVMR 469

  Fly   468 HKGAKHLRCASRDLDFIQFHGLDTWGLLIAITFVSLLIVVILIKCLQRVFVSLISKIRKNRAE 530
            ||||||||..:.:|.:.|:|.||..|.|:.....:   .|:.:||...|:...:.|.:|.:.|
Mouse   470 HKGAKHLRPLAHNLTWYQYHSLDVIGFLLVCVVAT---AVLPVKCCLFVYQFFVKKAKKRKNE 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35A1	NP_524314.2	egt	19..474	CDD:223071	135/460 (29%)
Ugt35A1	NP_524314.2	UDPGT	55..526	CDD:278624	149/501 (30%)
Ugt2b35	NP_766469.1	egt	8..506	CDD:223071	145/493 (29%)
Ugt2b35	NP_766469.1	UDPGT	24..525	CDD:278624	150/512 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840430
Domainoid	1	1.000	259	1.000	Domainoid score	I1975
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2975
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm42461
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.690