DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35A1 and Ugt2b5

DIOPT Version :9

Sequence 1:	NP_524314.2	Gene:	Ugt35A1 / 41334	FlyBaseID:	FBgn0026315	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_033493.3	Gene:	Ugt2b5 / 22238	MGIID:	98900	Length:	530	Species:	Mus musculus

Alignment Length:	555	Identity:	155/555 - (27%)
Similarity:	271/555 - (48%)	Gaps:	69/555 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 ILLIGLIWLFAANADEGVQSSRILAVFPFPGRSQYIFAEQFMKELAHRGHNVTVINTFG----SD 72
            :||:.:...|     ..|:..::| |:|.. .|.::..:..:.||..|||.|||:....    ..
Mouse     9 LLLLQISCCF-----RSVKCGKVL-VWPME-FSHWMNIKIILDELVQRGHEVTVLRPSAYYVLDP 66

  Fly    73 KNEPNFRV------IGAKKIHEIMAAFGNADYTQTASQWQMLTMTTQFLNLLTTSILDD------ 125
            |..|..:.      :....:......|.:. :|     ::|...|....:.|..:::|:
Mouse    67 KKSPGLKFETFPTSVSKDNLENFFIKFVDV-WT-----YEMPRDTCLSYSPLLQNMIDEFSDYFL 125

  Fly   126 AAVKDLLNSGE--------KFDLVIMEAVQT--EALFGLIQHFGAETIGIS-SYGTDTHIDELMG 179
            :..||::::.|        |||:::.:.|.:  |.:..|:|.....:|..| .|    .|::..|
Mouse   126 SLCKDVVSNKELMTKLQESKFDVLLSDPVASCGELIAELLQIPFLYSIRFSPGY----QIEKSSG 186

  Fly   180 N-ISPLSYNPLLLSSRTEQMDFKDRVMNV-----FEASVMWLHKRIVHLPSQRDLYAKYF--PTA 236
            . :.|.||.|::||....||.|.:|:.|:     |:   .|.  ::.:.......|::|.  ||
Mouse   187 RFLLPPSYVPVILSGLGGQMTFIERIKNMICMLYFD---FWF--QMFNDKKWDSFYSEYLGRPT- 245

  Fly   237 RKSLDEVLDSFALMLLGQHFSLSYPRPYLPNMIEVGGLHLQQKRKVQPLAKELSEFVEQS-EKGV 300
              :|.|.:....:.|:..::.|.:|.|.|||:..|||||.   :..:||.|::.|||:.| :.||
Mouse   246 --TLVETMGQAEMWLIRSNWDLEFPHPTLPNVDYVGGLHC---KPAKPLPKDMEEFVQSSGDHGV 305

  Fly   301 IYFSMGSNIKSKDLPPSTRKMLMQTFASVPQRVLWKFEDDQLPEKPDNVFISKWFPQPDILAHPN 365
            :.||:||.:  .::.......:....|.:||:|||||:.........|..:.||.||.|:|.||.
Mouse   306 VVFSLGSMV--SNMTEEKANAIAWALAQIPQKVLWKFDGKTPATLGHNTRVYKWLPQNDLLGHPK 368

  Fly   366 VKLFITHGGLLSTIESIYFGKPILGLPIFYDQHLNVQRAKQVGYGLSADIWSVNATELTPLIQEL 430
            .|.|:||||.....|:||.|.|::|:|:|.:||.|:......|..::.:|.:::.:::...::|:
Mouse   369 TKAFVTHGGANGVYEAIYHGIPMIGIPLFGEQHDNIAHMVAKGAAVALNIRTMSKSDVLNALEEV 433

  Fly   431 LSNPSYAAAAQTKSKLFRDQKETALERAIWWTEYVLRHKGAKHLRCASRDLDFIQFHGLDTWGLL 495
            :.||.|...|...|.:..||....|:||::|.|:|:|||.|||||....:|.:.|:|.||..|.|
Mouse   434 IENPFYKKNAMWLSTIHHDQPMKPLDRAVFWIEFVMRHKRAKHLRPLGHNLTWYQYHSLDVIGFL 498

  Fly   496 IAITFVSLLIVVILIKCLQRVFVSLISKIRKNRAE 530
            ::....:   :|:.:|||..::...:.|..|.:.|
Mouse   499 LSCVATT---IVLSVKCLLFIYRFFVKKENKMKNE 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35A1	NP_524314.2	egt	19..474	CDD:223071	136/490 (28%)
Ugt35A1	NP_524314.2	UDPGT	55..526	CDD:278624	145/506 (29%)
Ugt2b5	NP_033493.3	egt	8..489	CDD:223071	142/509 (28%)
Ugt2b5	NP_033493.3	UDPGT	24..527	CDD:278624	149/530 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840431
Domainoid	1	1.000	259	1.000	Domainoid score	I1975
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2975
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm42461
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.690