DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35A1 and ugt-3

DIOPT Version :9

Sequence 1:	NP_524314.2	Gene:	Ugt35A1 / 41334	FlyBaseID:	FBgn0026315	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_506203.2	Gene:	ugt-3 / 191174	WormBaseID:	WBGene00013903	Length:	529	Species:	Caenorhabditis elegans

Alignment Length:	542	Identity:	135/542 - (24%)
Similarity:	231/542 - (42%)	Gaps:	86/542 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 LAVFPFPGRSQYIFAEQFMKELAHRGHNVTVINTFGSD--------KNEPNFRVIGAKKIHEIMA 91
            |.:.|..|.|...|..:....||..|||||:......|        || ||..||..:...|..|
Worm    19 LIISPVFGYSHMKFMGRIADILADAGHNVTLFQPIIYDYYAHKKIVKN-PNIEVINYEVDEEEKA 82

  Fly    92 A---------FGNADYTQTASQWQMLT---MTTQFLNLLTTSILDDAAVKDLLNSGEKFDLVIME 144
            |         |..|..::.......:|   :..:|.::....:||....:.:|:  :.||..|.|
Worm    83 AASEASVFKFFWKAKGSKNPISSAKITSEKLYKEFEHICRKMLLDKELHRWILS--KNFDSHISE 145

  Fly   145 AVQTEALF--------GLIQHFGAETIGISSYGTDTHIDELMGNISPLSYNPLLLSSRTEQMDFK 201
            |.....|:        ..|..:.....|.:||.        :|...||:|.|...|:..::....
Worm   146 AFDFCGLYLGDFLKLKSPIPLYSGVRCGAASYA--------VGEPIPLNYLPTEGSNYGKKSSAI 202

  Fly   202 DRVMNV-------FEASVMWLHKRIVHLPSQRDLYAKYFPTAR-------KSLDEVLDSFALMLL 252
            ||:.::       |:..:               |:.|.:..|.       ::..|:|.|....|.
Worm   203 DRLSDMLGLTGYHFQFGI---------------LFDKQYDQAYRLTGGNVRTWQEILQSSTFFLT 252

  Fly   253 GQHFSLSYPRPYLPNMIEVGGLHLQQKRKVQPLAKELSEFVEQSEKGVIYFSMGSNIKSKDLPPS 317
            ..:..||:..|.:..:|::||..: :..|...|.:|.::.: ......|..|.|:.|:|.|:|..
Worm   253 NSNPYLSFSTPTISKVIQIGGFTI-ESFKTTTLDEEFNKIL-SLRNNTILVSFGTVIQSSDMPDD 315

  Fly   318 TRKMLMQTFASVPQRV-LWKFEDDQLPEK---PDNVFISKWFPQPDILAHPNVKLFITHGGLLST 378
            .:..|::.|..:|... :||:|:|....|   .:||.:|||.|||.:||...:.||:|||||.||
Worm   316 FKTGLIEAFRRMPDATFIWKYEEDDKTLKNKLSENVVLSKWIPQPALLADSRLDLFVTHGGLGST 380

  Fly   379 IESIYFGKPILGLPIFYDQHLNVQRAKQVGYGLSADIWS-VNATELTPLIQELLSNPSYAAAAQT 442
            :|..|.|...:.:|:|.||.:|.:...:.|..:..|.:. |::.:|...||.:|:|..|...::.
Worm   381 MEVGYAGVSSIMVPVFSDQGVNAEMLARHGGAIVYDKFDLVDSKKLMETIQMILNNSDYRKNSKR 445

  Fly   443 KSKLFRDQ----KETALERAIWWTEYVLRHKGAKHLRCASRDLDFIQFHGLDTWGLLIAITFVSL 503
            .|.:..:|    |:..|...    |:..|.....:|...:...:||:|:.||:..|::....|
Worm   446 LSDILHNQPMDPKQVLLNHC----EFAARFAQVDNLEPYANKYNFIEFYCLDSLALVVCTISV-- 504

  Fly   504 LIVVILIKCLQRVFVSLISKIR 525
             :.:::.|.|..|..|:|.|::
Worm   505 -VALVMFKILSFVVNSVIEKLK 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35A1	NP_524314.2	egt	19..474	CDD:223071	121/489 (25%)
Ugt35A1	NP_524314.2	UDPGT	55..526	CDD:278624	130/522 (25%)
ugt-3	NP_506203.2	egt	1..457	CDD:223071	117/465 (25%)
ugt-3	NP_506203.2	UDPGT	27..525	CDD:278624	132/532 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.810