DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35A1 and ugt-16

DIOPT Version :9

Sequence 1:	NP_524314.2	Gene:	Ugt35A1 / 41334	FlyBaseID:	FBgn0026315	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_506210.1	Gene:	ugt-16 / 191171	WormBaseID:	WBGene00013901	Length:	534	Species:	Caenorhabditis elegans

Alignment Length:	547	Identity:	151/547 - (27%)
Similarity:	243/547 - (44%)	Gaps:	76/547 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 SSRILAVFPFPGRSQYIFAEQFMKELAHRGHNVT-VINTFGSDKNEPNFRVIGAKKIHEIMA--- 91
            |.::|...|..|.|...|..:....|...|::|| :|..|.:.|.|    ::|:||:.:|:.
Worm    17 SYKVLVFNPAFGASHANFLGKISDILIDAGNDVTMLIPIFVNGKKE----LVGSKKVKKIIRIDQ 77

  Fly    92 --------AFGNADYTQTASQWQMLTMTTQFLNLL----------TTSILDDAAVKDLLNSGEKF 138
                    ..|:.:.....:.|:|.:..|.....:          |..:.....:.:.|.. |||
Worm    78 DPRIAQIHKEGSTEEIMRKTIWKMDSAITSMFGFIGNFSKTAAYQTEYMFQQTELIEQLRK-EKF 141

  Fly   139 DLVIMEAVQTEALFGLIQHFGA----ETIGISS-YGTDTHI-----DELMGNISPLSYNPLLLSS 193
            ||.|     ||:||     .||    :.|||.| ...|:.:     ...:|..:.:||.|.|.||
Worm   142 DLAI-----TESLF-----LGAFALFDEIGIRSVINADSTLYMGGMKGALGEPAAISYYPGLFSS 196

  Fly   194 RTEQMDFKDRVMNV------FEASVMWLHKRIVHLPSQRDLYAKYFPTARKSLDEVLDSFALMLL 252
            ..::|:|..||.|.      ...||:.....||..|       |.:..:| ...|.|.:.|...:
Worm   197 IDDKMNFFGRVKNAVGYLFGLWFSVLKYDDEIVAFP-------KSYKGSR-DWREHLSNVAFNFI 253

  Fly   253 GQHFSLSYPRPYLPNMIEVGGLHLQQKRK-VQPLAKELSEFVEQSEKGVIYFSMGSNIKSKDLPP 316
            ..:..:.|..|.||..:.|||:.:..|:. ...|:||.::.:...:..|: .|.|||..|.|:|.
Worm   254 NSNQYIDYASPTLPKTVFVGGMQVNTKKSGKSTLSKEWNDVLSLRKTNVL-VSFGSNAYSSDMPD 317

  Fly   317 STRKMLMQTFASVPQRV-LWKFE------DDQLPEKPDNVFISKWFPQPDILAHPNVKLFITHGG 374
            ..:|..::.|||:|:.. :||:|      .|.||    ||.::.|.||.||||...:.|||||||
Worm   318 EFKKSFLEVFASMPETTFIWKYEVANATLVDHLP----NVKLTTWMPQNDILADDRLTLFITHGG 378

  Fly   375 LLSTIESIYFGKPILGLPIFYDQHLNVQRAKQVGYGLSAD-IWSVNATELTPLIQELLSNPSYAA 438
            |.|::|..|.|||.:.:|:..||..|.....:.|..|..| .|..|:.:|...||.:|::.||..
Worm   379 LGSSVELAYQGKPAVVIPLMADQPRNAHMLTRHGGALQLDKTWLNNSEKLREAIQTVLNDVSYKH 443

  Fly   439 AAQTKSKLFRDQKETALERAIWWTEYVLRHKGAKHLRCASRDLDFIQFHGLDTWGLLIAITFVSL 503
            .|:..:|:..||.....:..:...::.::......|....|.|:..|::.:|....:..|..|.|
Worm   444 NAERLAKILEDQPHKPKDVVLKHCDFAVQFGPLDTLNSEGRLLNTFQYYSVDIVLAIFVILSVIL 508

  Fly   504 LIVVILIKCLQRVFVSLISKIRKNRAE 530
            .:|.::||.|.| |:..:..|.|.:.:
Worm   509 FVVYLVIKLLFR-FLGRLFSISKRKVD 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35A1	NP_524314.2	egt	19..474	CDD:223071	135/489 (28%)
Ugt35A1	NP_524314.2	UDPGT	55..526	CDD:278624	144/517 (28%)
ugt-16	NP_506210.1	UDPGT	19..532	CDD:278624	150/541 (28%)
		egt	<246..503	CDD:223071	78/261 (30%)
		HemY_N	483..>531	CDD:284604	14/48 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.810