DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35A1 and ugt-31

DIOPT Version :9

Sequence 1:	NP_524314.2	Gene:	Ugt35A1 / 41334	FlyBaseID:	FBgn0026315	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_001021756.1	Gene:	ugt-31 / 189771	WormBaseID:	WBGene00021464	Length:	521	Species:	Caenorhabditis elegans

Alignment Length:	517	Identity:	126/517 - (24%)
Similarity:	228/517 - (44%)	Gaps:	51/517 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 ILAVFPFPGRSQYIFAEQFMKELAHRGHNVTVI------------------NTFGSDKNEPNFRV 80
            ||...|..|.|...|.......|...|||||.:                  |....||  |||..
Worm    19 ILVYSPVFGGSHSKFMGNIADTLTEAGHNVTFLVSVADVTRRHEIGVKLTKNVIIVDK--PNFSQ 81

  Fly    81 IGAK-KIHEIMAAFGNADYTQTASQWQMLTMTTQFLNLLTTSILDDAAVKDLLN--SGEKFDLVI 142
            ...: .:.|::...    :|.........|....|:.::.|:..:..:.:::..  |..:|.:.|
Worm    82 DDVEIDMDEVLRPL----WTIQNRPSDFATCFEFFIQMMQTTCAEFTSNREIFKKLSKTEFHVAI 142

  Fly   143 MEAVQTEALFGLIQHFGAETIGISSYGTDTHIDELMGNISPLSYNPLLLSSRTEQMDFKDRVMNV 207
            .|.|....| |.....|.:...::|  :.||.:.::.|    |..|:.:|.......:.|..|::
Worm   143 AEPVSICGL-GYFDALGIKKTILAS--STTHYEGVVRN----SGEPVDMSYVPVHGAYFDEKMDI 200

  Fly   208 FEASVMWLHKRIVHLPSQRDLYAKYFPTARKSL-------DEVLDSFALMLLGQHFSLSYPRPYL 265
            |:....|..:.::....:| ::.:.....||:|       .:::.|.:||....:..|.:|||.|
Worm   201 FQRYTNWASEHVLAGNLER-MFDQEMSEYRKNLVQSTGHWRDLIPSASLMFTNSNPYLDFPRPVL 264

  Fly   266 PNMIEVGGLHLQQKR-KVQPLAKELSEFVEQSEKGVIYFSMGSNIKSKDLPPSTRKMLMQTFASV 329
            ...:.:||:.:..:: |.:.|.:::::.:|:.|..:: .|.||.:||..:|...|..::....:.
Worm   265 QKTVGIGGITVDMEQIKSEKLPEKINKLLEKREYNML-ISFGSMVKSSTMPEKWRNSILSAIRNF 328

  Fly   330 PQ-RVLWKFEDDQL--PEKPDNVFISKWFPQPDILAHPNVKLFITHGGLLSTIESIYFGKPILGL 391
            |. ..:||:|.|.|  .|..:||...||.||..:|.:|.|..|:|||||.||.|..:.|||.:.:
Worm   329 PNVTFIWKYESDDLRWAENVENVHFLKWIPQTALLNNPRVSAFLTHGGLGSTNELAFIGKPSIIV 393

  Fly   392 PIFYDQHLNVQRAKQVGYGLSADIWSV-NATELTPLIQELLSNPSYAAAAQTKSKLFRDQKETAL 455
            |||.||..|.....:.|..|....:.: ||..|...|.:::.:.|||..|:|.:.|......:..
Worm   394 PIFGDQGRNAPMLARHGGALVLQKFDLENAEVLIDFIGKIVFDKSYAKNAKTLANLLNASPFSPK 458

  Fly   456 ERAIWWTEYVLRHKGAKHLRCASRDLDFIQFHGLDTWGLLIAITFVSLLIVVILIKCLQRVF 517
            |..:..||:|........:....|.|::.|....|.: |::.:.:.|::::.|.:  :::||
Worm   459 ELVVKNTEFVGNFGPLTQMDPYIRKLNWFQRTFADIY-LILFLVYASIIVIPIYV--IRKVF 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35A1	NP_524314.2	egt	19..474	CDD:223071	117/472 (25%)
Ugt35A1	NP_524314.2	UDPGT	55..526	CDD:278624	120/496 (24%)
ugt-31	NP_001021756.1	UDPGT	28..518	CDD:278624	122/508 (24%)
ugt-31	NP_001021756.1	Glycosyltransferase_GTB_type	<248..472	CDD:299143	70/224 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.810