DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35A1 and ugt-10

DIOPT Version :9

Sequence 1:	NP_524314.2	Gene:	Ugt35A1 / 41334	FlyBaseID:	FBgn0026315	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_504313.2	Gene:	ugt-10 / 188619	WormBaseID:	WBGene00020594	Length:	536	Species:	Caenorhabditis elegans

Alignment Length:	556	Identity:	142/556 - (25%)
Similarity:	239/556 - (42%)	Gaps:	90/556 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 VQSSRILAVFPFPGRSQYIFAEQFMKELAHRGHNVTVI--------NTFGSDKNEPNFRVIGAKK 85
            :....||...|..|.|...|..:....:|..||||||.        ||.|..||: |.:.|....
Worm    17 ILGKNILIFNPIFGFSHVKFVSKLADIIADHGHNVTVFQPFHIALKNTEGLIKNK-NIKFINYYP 80

  Fly    86 IH--EIMAAFGNADYTQTASQ-WQMLTMTTQFLNLL-------------TTSILDDAAVKDLLNS 134
            .|  |::..     .|||... |....|....::.:             .|.::.|..|.:.|.|
Worm    81 DHYDELLKT-----ETQTFPMFWDSHLMNNPVVSAVMMAKALSSTFERTATQLVKDQNVLNNLKS 140

  Fly   135 GEKFDLVIMEAVQTEALFGLIQH-FGAETIGISSYGTDTHIDELMGNISPLSYNPLLLSSRTEQM 198
             :|||::|.|..:...::  :.| .....|.|.|.......::..|..|.|.|.||..|......
Worm   141 -KKFDVMISETFELTGMY--VAHLINVPCIPIWSAVRFLVFNKAFGQPSTLGYIPLEGSKMAPDF 202

  Fly   199 DFKDRVMNV---------------FEASVMWLHKRIVH-LPSQRDLYAK---YFPTARKSLDEVL 244
            .|.||:.:|               ::.::  :.|.:.| :|..:||.::   |...:...||
Worm   203 GFFDRLNDVYRDFFGQIGMDRLGQYQNNI--IEKAVGHSVPYWKDLVSQSPIYITNSNPYLD--- 262

  Fly   245 DSFALMLLGQHFSLSYPRPYLPNMIEVGG--LHLQQKRKVQPLAKELSEFVEQSEKGVIYFSMGS 307
              ||:..             .|.::.:||  :.|::.:....|.:|..:.:::.|..|: .|.||
Worm   263 --FAVAT-------------TPAIVHIGGITIDLEKIKHADELPEEYEKILQERESTVL-ISFGS 311

  Fly   308 NIKSKDLPPSTRKMLMQTFASVPQ-RVLWKFEDDQL---PEKPDNVFISKWFPQPDILAHPNVKL 368
            .|:|.::|.:.:..|::.|.|:|. ..:||:|.|.:   ...|.||.:.||.|||.:||...|||
Worm   312 VIRSYEMPDNFKAGLIKMFESLPDVTFIWKYERDDVEFQKRLPKNVHLKKWVPQPSLLADKRVKL 376

  Fly   369 FITHGGLLSTIESIYFGKPILGLPIFYDQHLNVQRAKQVGYGLSADIWSV-NATELTPLIQELLS 432
            |:|||||.||:|..|.|||.|.:|||.||..|.....:.|..::.|.:.: |..:||..::|:::
Worm   377 FVTHGGLGSTMEVAYTGKPALSVPIFGDQPENADMLARHGGAIAYDKFDLANGEKLTKTVREMVT 441

  Fly   433 NPSYAAAAQTKSKLFRDQKETALERAIWWTEYVLRHKGAKHLRCASRDLDFIQFHGLDTWGLLIA 497
            ||.::..|:....:...|........:...|:.:.....:....|...|.:|..:.||      .
Worm   442 NPKFSKNAEALRDVLLKQPIDPKMNLMKHLEFAMEFPNHRSQVPAINKLGWIAHYYLD------V 500

  Fly   498 ITFVSLLIV---VILIKCLQRVFVSLISKIRKNRAE 530
            |.|::|::|   .::.:..:.|||.:....:|.:.|
Worm   501 IAFLTLVVVGFLYLIFRFTKIVFVRIGILNKKAKTE 536

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35A1	NP_524314.2	egt	19..474	CDD:223071	128/495 (26%)
Ugt35A1	NP_524314.2	UDPGT	55..526	CDD:278624	134/524 (26%)
ugt-10	NP_504313.2	egt	1..463	CDD:223071	127/475 (27%)
ugt-10	NP_504313.2	UDPGT	31..535	CDD:278624	137/539 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5496
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.760