DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35A1 and ugt-56

DIOPT Version :9

Sequence 1:	NP_524314.2	Gene:	Ugt35A1 / 41334	FlyBaseID:	FBgn0026315	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_506074.2	Gene:	ugt-56 / 188073	WormBaseID:	WBGene00011453	Length:	524	Species:	Caenorhabditis elegans

Alignment Length:	560	Identity:	128/560 - (22%)
Similarity:	223/560 - (39%)	Gaps:	98/560 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 ILLIGLIWLFAANADEGVQSSRILAVFPFPGRSQYIFAEQFMKELAHRGHNVTVI-NTFGSD-KN 74
            |:.:|.:.::.:..|       ||...|...:|...|..:....||.|||.|||| |.|..| .|
Worm     6 IVWLGALCIYGSAFD-------ILIYAPRMMQSHVYFTARIANVLAARGHKVTVIDNVFRYDVDN 63

  Fly    75 EPNFRVIGAKKIHEIMAAFGNADYTQTASQWQMLTM-----------------TTQFLNLLTTSI 122
            |.      :..||||::...:.:.|:..:...:.|:                 ......|..|.:
Worm    64 EL------SSDIHEIISVEPSPEVTKLLNTGSLPTILWNSKASPEEQRTIMEGLGHVHRLQCTHL 122

  Fly   123 LDDAAVKDLLNSGEKFDLVIMEAVQTEALFGLIQHFGAE-TIGISSYGTDTHIDELMGNISPLSY 186
            ::::.:...|.. .|||..|.|...:..: |:::..|.: |:.:||.|....:...:| ||....
Worm   123 IENSTLIPKLQE-IKFDFAIHEVFDSCGV-GILEVIGVQKTVIVSSTGPMDVVPITLG-ISDTLN 184

  Fly   187 NPLLLSSRTEQMDFKDRVMNV-FEASVMWLHKRIVHLPSQRDLYAKYFPTARKSLDEVLDSFALM 250
            .|.|||.....:.|.::..|: |.:.::..|:....:.|  .|:.||: ..:|...|::....|:
Worm   185 TPSLLSDYGSYLSFFEKRRNLKFLSGMLNFHEMQDSMIS--PLFKKYY-GLKKPTGEIMRQANLL 246

  Fly   251 LLGQHFSLSYPRPYLPNMIEVGGLHLQQKRKVQPLAKELSEFVEQSEKGVIYFSMGSNIKSKDLP 315
            ....|......|.......::||:..:.::.   |..|....:......|: .|.|:...|..:|
Worm   247 FYNIHEGSDGMRMRGRRSFDIGGIAFKDQKN---LTMEYQTLLSDPRPKVL-VSFGTAATSSHMP 307

  Fly   316 PSTRKMLMQTFASVPQRV-LWKFE-DDQLPEKPD---NVFISKWFPQPDILAHPNVKLFITHGGL 375
            .:.:..||.....:...: :||:| :|...::.:   |:...|:.||.|:||...:.||:||.|.
Worm   308 QNLKNSLMTAMKQMNNVLFIWKYEMEDNFTKQEELTTNIIFKKFLPQTDLLASSKIDLFVTHCGQ 372

  Fly   376 LSTIESIYFGKPILGLPIFYDQHLNVQRAKQVG---------YGLSADIWSVNATELTP---LIQ 428
            .|.:|:...|..:|.:|:|.|||.|.:.|.:.|         ....|.|.....|.|.|   |.|
Worm   373 NSLLEAFNSGVRVLAVPLFGDQHRNAKLAFENGLIEILPKSDIETPAKIVKAVKTGLEPNAKLDQ 437

  Fly   429 ELLSNPSYAAAAQTKSKLFRDQKETALE------RAIWWTEYVLRHKGAKHLRCASRDLDFIQFH 487
            .::          ..|.|.|:.||.|..      .|.:.||:               ..:|.:|.
Worm   438 NIV----------LISSLLRNSKENAENLLISTIEATYSTEF---------------PPNFSKFP 477

  Fly   488 GLDTWGLLIAITFVSLLIVVILIKCLQRVFVSLISKIRKN 527
            .......|:.:...|:.:|.:|.     :|| .::..|||
Worm   478 KNYHPNTLVRLIDSSIALVFMLF-----IFV-FVNHFRKN 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35A1	NP_524314.2	egt	19..474	CDD:223071	115/498 (23%)
Ugt35A1	NP_524314.2	UDPGT	55..526	CDD:278624	117/514 (23%)
ugt-56	NP_506074.2	Glycosyltransferase_GTB_type	<216..>399	CDD:299143	46/189 (24%)
ugt-56	NP_506074.2	Glycosyltransferase_GTB_type	<353..453	CDD:299143	34/109 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.810