DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35A1 and ugt-19

DIOPT Version :9

Sequence 1:	NP_524314.2	Gene:	Ugt35A1 / 41334	FlyBaseID:	FBgn0026315	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_500912.2	Gene:	ugt-19 / 187129	WormBaseID:	WBGene00019515	Length:	532	Species:	Caenorhabditis elegans

Alignment Length:	573	Identity:	154/573 - (26%)
Similarity:	253/573 - (44%)	Gaps:	99/573 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 LIGLIWLFAANADEGVQSSRILAVFPFPGRSQYIFAEQFMKELAHRGHNVTVINTFGSD------ 72
            |..:|.:|||... ...|.:||......|.|...|.......|...||||||:.....|
Worm     3 LFSIILIFAATIC-FASSYKILFYTNLFGHSHVKFLGAAADILTDAGHNVTVVMPVFDDSIKTSL 66

  Fly    73 KNEPNFRVIGAKKIHEIMAAFGNADYTQTASQWQM-----LTMTT-----------QFLNLLT-T 120
            |:..|...:.:.   :.:|||..|......:.|.|     .||.|           |...:|| |
Worm    67 KSTKNIIFVNSS---DDVAAFAKARTKMLNNLWTMDNTNPFTMLTRVGMMSNTFSSQCKKVLTNT 128

  Fly   121 SILD-------DAAVKDLLNSGEKFDLV---IMEAVQTEALFGLIQHFGAETIGISSYGTDTHID 175
            .:::       |.||.      |.|||.   ..||:...|      |     :||.|.....|:.
Worm   129 ELIETMKAENYDLAVT------EPFDLCAYPFFEAINIRA------H-----VGILSSSRLDHVS 176

  Fly   176 ELMGNISPLSYNPLLLSSRTEQMDFKDRVMNVF---------------EASVMWLHKRIVHLPSQ 225
            :::|..:..||||.|:|:.:::|....|.:||.               ||.|:
Worm   177 DVIGQPAAPSYNPGLMSTNSDRMTMWQRFVNVIQYACGSYFFSYIGDREAEVV------------ 229

  Fly   226 RDLYAKYFPTARKSLDEVLDSFALMLLGQHFSLSYPRPYLPNMIEVGGLHLQQKRKVQPLAKELS 290
            :::..|:     :|..||:...:.::..|...|.:|.|....:|.:|||.::..:|...|.::.|
Worm   230 KEINPKW-----RSWREVVPEASFIMTNQIPLLDFPAPTFDKIIPIGGLSVKTDKKSLKLEEKWS 289

  Fly   291 EFVEQSEKGVIYFSMGSNIKSKDLPPSTRKMLMQTFASVPQRV-LWKFED--DQLPEKPDNVFIS 352
            :.::..:|.| :.|.|||.:|.|:|...:...:|...|:|... :||:||  |:..|..:||::.
Worm   290 KILDIRKKNV-FISFGSNARSVDMPLEYKNTFLQVIKSMPDTTFIWKYEDLNDKFTEGIENVYLG 353

  Fly   353 KWFPQPDILAHPNVKLFITHGGLLSTIESIYFGKPILGLPIFYDQHLNVQRAKQVGYGLS----A 413
            .|.||.::||...:.:|:|||||.|..|....|.|.:.:|:|.||..|.|..|:.| |::    .
Worm   354 DWLPQNELLADKRLNVFVTHGGLGSVTELSMMGTPAVMIPLFADQSRNGQMLKRHG-GVAVLKKT 417

  Fly   414 DIWSVNATELTPLIQELLSNPSYAAAAQTKSKLFRDQKETALERAIWWTEYVLRHKGAKHLRCAS 478
            |:......:.|  |:|:|:||.|..:|:..:::.|:|.....|..:.:.|:..|......:....
Worm   418 DLSDAKLVQST--IEEVLNNPEYRKSAERVAEMLRNQPTNPKETFLKYVEFTARFGKLPSMDNYG 480

  Fly   479 RDLDFIQFHGLDTWGLLIAITFVSLLIVVILIKC-LQRVFVSLISKIRKNRAE 530
            |.|.|:|:..||...::..||.|.|.|...:|:| :::.|.|..|: .|::.|
Worm   481 RQLTFVQYFFLDIISIISLITVVFLYISYKVIRCTIKKCFGSRSSE-EKSKKE 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35A1	NP_524314.2	egt	19..474	CDD:223071	134/509 (26%)
Ugt35A1	NP_524314.2	UDPGT	55..526	CDD:278624	141/526 (27%)
ugt-19	NP_500912.2	egt	1..472	CDD:223071	136/510 (27%)
ugt-19	NP_500912.2	UDPGT	32..521	CDD:278624	140/529 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R17022
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.840