DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35A1 and ugt-14

DIOPT Version :9

Sequence 1:	NP_524314.2	Gene:	Ugt35A1 / 41334	FlyBaseID:	FBgn0026315	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_504316.1	Gene:	ugt-14 / 186767	WormBaseID:	WBGene00019233	Length:	531	Species:	Caenorhabditis elegans

Alignment Length:	547	Identity:	147/547 - (26%)
Similarity:	231/547 - (42%)	Gaps:	93/547 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 VQSSRILAVFPFPGRSQYIFAEQFMKELAHRGHNVTVI--------NTFGSDKNEP--------- 76
            :....||...|....|...|..|....:|..|||||:.        ||.|..||..
Worm    16 ISCKNILIFNPIFAFSHVKFVTQMADIIADHGHNVTLFQPYHIAMKNTEGLVKNRKVNIINYYPH 80

  Fly    77 NFRVI-GAKKIHEIMAAFGNADYTQTA--SQWQMLTMTTQFLNLLTTSILDDAAVKDLLNSGEKF 138
            :|..| ||  :.|..:...::.....|  |.:.|.....:......|.:|.|.::.:.|.| .||
Worm    81 DFNTISGA--MPETFSGLWDSKLLNNAILSAYAMPKAIGRVFEKTATQLLQDESILEELKS-RKF 142

  Fly   139 DLVIMEAVQTEALFGLIQHFGAETIGISSYGTDTHIDELMGNISPLSYNPLLLSSRTEQMDFKDR 203
            ::||.||.:...:: |.......:|.|.|.......:...|..|.|.|.|....||  ::.|.||
Worm   143 EVVISEAFEITEMY-LAHLLKIPSIPIKSSVRYPAFNNAFGQPSSLGYLPQQGLSR--EIGFLDR 204

  Fly   204 VMNVF-------------EASVMWLHKRIVH-LPSQRDLYAK---YFPTARKSLDEVLDSFALML 251
            ::.|:             |..|.::.|.:.| :|..|||..:   |...:...||     ||:
Worm   205 LLEVYDHYFLVKMQERLNEYQVNFIEKALGHPVPHWRDLVKESPIYITNSNPYLD-----FAV-- 262

  Fly   252 LGQHFSLSYPRPYLPNMIEVGGLHLQQKRKVQP--LAKELSEFVEQSEKGVIYFSMGSNIKSKDL 314
                       |....::.|||:.:..|:...|  |..|..|.:::.:..|: .|.||.::|.|:
Worm   263 -----------PTTATVVHVGGITMDMKKLKNPQQLPDEYEEILQERDSTVL-ISFGSVVRSCDM 315

  Fly   315 PPSTRKMLMQTFASVPQ-RVLWKFEDDQL---PEKPDNVFISKWFPQPDILAHPN-VKLFITHGG 374
            |.:.:..:::.|.|:|. ..:||:|.|.:   .:.|.||.:.||.|||.:||... ||.|:||||
Worm   316 PENFKAGVVKMFESLPDITFIWKYEKDDVEFQKKLPKNVHLKKWVPQPSLLADKRFVKRFVTHGG 380

  Fly   375 LLSTIESIYFGKPILGLPIFYDQHLNVQRAKQVGYGLSAD-IWSVNATELTPLIQELLSNPSYAA 438
            |.||:|..|.|||.|.:|||.||..|.....:.|..:..| :...:..:.|..::|::.||.|..
Worm   381 LGSTMEVAYTGKPALMVPIFADQFNNANMLARHGGAIPYDKLDLADGEKFTKTVREMVINPKYND 445

  Fly   439 AAQTKSKLFRDQK-ETALERAIWWTEYVLRHKGAKHLRCASRDLDF----IQFHGLDTWGLLIAI 498
            .|:....:..:|. :..|..             .|||..|   ::|    .|...::..| ||..
Worm   446 NAKVLLIILLNQPIDPKLNL-------------MKHLEFA---MEFPNLRSQIPEINNAG-LIGY 493

  Fly   499 TFVSLLIVVILIKCLQ-RVFVSLISKI 524
            .::.::...||..||. .:|.:||.||
Worm   494 YYLDIIAFFILFACLALYLFTNLIFKI 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35A1	NP_524314.2	egt	19..474	CDD:223071	130/490 (27%)
Ugt35A1	NP_524314.2	UDPGT	55..526	CDD:278624	141/521 (27%)
ugt-14	NP_504316.1	egt	5..461	CDD:223071	128/469 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.810