DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35A1 and ugt-32

DIOPT Version :9

Sequence 1:	NP_524314.2	Gene:	Ugt35A1 / 41334	FlyBaseID:	FBgn0026315	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_504060.2	Gene:	ugt-32 / 185911	WormBaseID:	WBGene00018543	Length:	527	Species:	Caenorhabditis elegans

Alignment Length:	569	Identity:	142/569 - (24%)
Similarity:	232/569 - (40%)	Gaps:	100/569 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LLIGLIWLFA--ANADEGVQSSRILAVFPFPGRSQYIFAEQFMKELAHRGHNVTVINTFGSDKNE 75
            ||..|:.|::  :|.|    |.|:|...|....|...|..:....|...|||||.......:..:
Worm     3 LLFKLMILYSVFSNTD----SLRVLVYSPAYAASHTNFMARLADTLTEAGHNVTFFTPIIDESRK 63

  Fly    76 PNFRVIGAKKIHEI-------------------MAAFGNADYTQTASQWQMLTMTTQFLNLLTTS 121
            ..|   |.|...::                   |..|...|.|.......|.|:..|.: ....:
Worm    64 DQF---GVKLTKDVLILEQDEQVKRNPVTIDNDMKYFWTTDVTSANGHKVMGTLHKQAI-FTCEN 124

  Fly   122 ILDDAAVKDLLNSGEKFDLVIMEAVQTEALFGLIQHFGAETIGISSYGTDTHIDELM---GNISP 183
            :.....:.|.|.| ..:|:.:.|.:.|..| .|.:|.|.|.:.:::  :.|:.|.|:   |....
Worm   125 VFKHQELIDELRS-RNYDIGLAEPLMTCGL-ALFRHIGIEKVMLTT--SCTNYDILLPATGEPED 185

  Fly   184 LSYNPLLLSSRTEQMDFKDRVMNVFEASVMWLHKRIVHLPS-------QRDLYAKY----FPTAR 237
            .||||.:.|..|:.|.|..|:.|.....||        :|:       :.::|.||    ||..|
Worm   186 TSYNPSMNSQVTDVMSFWQRLENYDLYHVM--------IPTFETIFDDEANVYRKYLGESFPDWR 242

  Fly   238 KSLDEVLDSFALMLLGQHFS-----LSYPRPYLPNMIEVGGLHLQQKRKVQPLAKELSEFVEQSE 297
               |.:.|:      ..||:     |.:|||.:...||:||:.:..: .:.|:.:|.|..:::..
Worm   243 ---DLIPDA------SLHFTNSIPFLDFPRPSIQKTIEIGGIAVDIE-SIPPVNEEFSNILDKRP 297

  Fly   298 KGVIYFSMGSNIKSKDLPPSTRKMLMQTFASVPQ-RVLWKFEDDQLPEKPD--NVFISKWFPQPD 359
            ..:: .|.||..:|.::|...::.|::.|.|.|. ..:||:|.|.:....|  ||...||.||..
Worm   298 MNML-ISFGSLARSTEMPIIFKENLLRVFQSEPNCTFIWKYESDDVAFANDVENVIFVKWMPQTA 361

  Fly   360 ILAHPNVKLFITHGGLLSTIESIYFGKPILGLPIFYDQHLN-----------VQRAKQVGYGLSA 413
            ||....:..|:|||||.||.|:.:.|||.:..|||.||..|           |.....:|
Worm   362 ILKDNRLTAFLTHGGLGSTNEAAFLGKPSVMFPIFADQSRNSNMLGRQEMSIVLHKSDLG----- 421

  Fly   414 DIWSVNATELTPLIQELLSNPSYAAAAQTKSKLFRDQKETALERAIWWTEYVLRHKGAKHLRCAS 478
                 |..::.....|:|.|..|...|:..:.:.|:|.....:..:...|:|.|.....|:...|
Worm   422 -----NFQKIRDAFHEILHNEKYHLNARKVADMVRNQPAKPRDIFVKHVEFVGRFGPLHHMTPYS 481

  Fly   479 RDLDFIQFHGLDTWGLLIAITFVSLLIVVILIKCLQRVFVS--LISKIR 525
            ..:.|.|.:..|   :.|.....:..|.|:.:.|:.::..|  .:.||:
Worm   482 LKMPFYQRYHYD---IFIFKFLTNYFIPVVFLLCVTKLIFSKFQLKKIK 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35A1	NP_524314.2	egt	19..474	CDD:223071	127/508 (25%)
Ugt35A1	NP_524314.2	UDPGT	55..526	CDD:278624	130/525 (25%)
ugt-32	NP_504060.2	Glycosyltransferase_GTB_type	1..508	CDD:299143	137/548 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.810