DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35A1 and ugt-34

DIOPT Version :9

Sequence 1:	NP_524314.2	Gene:	Ugt35A1 / 41334	FlyBaseID:	FBgn0026315	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_505728.2	Gene:	ugt-34 / 185120	WormBaseID:	WBGene00009255	Length:	526	Species:	Caenorhabditis elegans

Alignment Length:	528	Identity:	138/528 - (26%)
Similarity:	229/528 - (43%)	Gaps:	55/528 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 SSRILAVFPFPGRSQYIFAEQFMKELAHRGHNVTVINTFGSDKNEPNFRVI----------GAKK 85
            |...|...|....|.:.|..:....|...|||||.:......:.| |.:.:          ..|:
Worm    22 SYNYLVFCPLFAHSHHKFLAKIADTLTEAGHNVTFLMPIIHREYE-NVKYLEHTTDIVYIQPDKE 85

  Fly    86 IHEIMAAFGNADY-TQTASQWQMLTM---TTQFLNLLTT--SIL-DDAAVKDLLNSGEKFDLVIM 143
            :.||..   |||| |...:.:.:||.   ..:|..:.|.  .|| .|.:|.|.|.: .|||.:|.
Worm    86 LEEIAQ---NADYSTFWKNDFGILTFIPAIERFFRMFTKVHDILKKDLSVLDNLKN-RKFDAMIF 146

  Fly   144 EAVQTEALFGLIQHFGAETIGISSYGTDTHIDEL---MGNISPLSYNPLLLSSRTEQMDFKDRVM 205
            |::...| ..:.::...:|| ..|:.. ||:.||   :|..|..::.|:.:|...::|.||:|::
Worm   147 ESLAFCA-HPIREYLEIKTI-FPSWSM-THMTELSQAIGEPSSPTFLPITISPFGDKMTFKERLL 208

  Fly   206 NVFEASVMWLHKRIVHLPSQRDLYAKYFPTARKSLDEVLDSFALMLLGQHFSLSYPRPYLPNMIE 270
            |.. |...:.|  |...|:   |.:..:|.......|:|.....:....:..|.:|||.|...||
Worm   209 NTL-ADFTFTH--IFQPPT---LTSFKYPHQTFDFKEILSQAPFIFFNSNPFLDFPRPTLTKTIE 267

  Fly   271 VGGLHLQQK-RKVQPLAKELSEFVEQSEKGVIYFSMGSNIKSKDLPPSTRKMLMQTFASVPQ-RV 333
            :||:.:... .:::.|.:|.:..:...::.|: .|.||.::|.::|...:..:.|...|.|. ..
Worm   268 IGGISVNATLMRLEKLPEEYNTILNLKQQNVL-ISFGSMLRSSEMPVEYKDTIAQVVRSFPSVTF 331

  Fly   334 LWKFEDD--QLPEKPDNVFISKWFPQPDILAHPNVKLFITHGGLLSTIESIYFGKPILGLPIFYD 396
            :||:|::  :..|...|....||.||..:||...:..||||.||.|..|..|.|||.:.:|||.|
Worm   332 IWKYENNNVEFAENLPNFHFFKWVPQTALLADSRLSAFITHAGLGSINELSYIGKPAILVPIFAD 396

  Fly   397 QHLNVQRAKQVGYGLSADIWSVNATE-LTPLIQELLSNPSYAAAAQTKSKLFRDQKETALERAIW 460
            |..|.:...:....:..|...:...: |...:..:|::.||...|...|:....|..:..:..:.
Worm   397 QLRNAKMLVRHNGSIELDKKDLGKFDVLRDAVDAILNDKSYTNNAILLSQQLESQPFSPHDLLVK 461

  Fly   461 WTEYVLRHKGAKHLRCAS-----RDLDFIQFHGLDTWGLLIAITFVSLLIVVILIKCLQRVFVSL 520
            :.|:     |||.....|     |.:.|..|..:|.. |.:..||.   |.|.:...|.|||...
Worm   462 YAEF-----GAKFGELPSLDPHYRKMSFFSFFMIDII-LFLTATFA---IFVSISLYLFRVFFKS 517

  Fly   521 ISKIRKNR 528
            :. :||.:
Worm   518 VF-VRKEK 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35A1	NP_524314.2	egt	19..474	CDD:223071	122/467 (26%)
Ugt35A1	NP_524314.2	UDPGT	55..526	CDD:278624	131/500 (26%)
ugt-34	NP_505728.2	UDPGT	35..518	CDD:278624	133/506 (26%)
ugt-34	NP_505728.2	Glycosyltransferase_GTB_type	<248..500	CDD:299143	67/258 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.810