DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt35A1 and ugt-41

DIOPT Version :9

Sequence 1:	NP_524314.2	Gene:	Ugt35A1 / 41334	FlyBaseID:	FBgn0026315	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_504818.2	Gene:	ugt-41 / 184295	WormBaseID:	WBGene00017336	Length:	527	Species:	Caenorhabditis elegans

Alignment Length:	556	Identity:	130/556 - (23%)
Similarity:	228/556 - (41%)	Gaps:	67/556 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LGILLIGLIWLFAANADEGVQSSRILAVFPFPGRSQYIFAEQFMKELAHRGHNVTVINTFGSDKN 74
            :.:|:|.|:.|..:|    ......|.|.|..|.|...|..:....|...||||||::...|.|
Worm     1 MNLLIILLLVLSISN----TSGFNYLVVSPAFGHSHSTFMGKLADSLTEAGHNVTVLSIIISSK- 60

  Fly    75 EPNFRVIG-AKKIHEIMAA------------FGNADY----TQTASQWQMLTMTTQFLNLLTT-- 120
               ||.|. .|...:|:..            ..|.|:    ||..:..:.:.....||.:...
Worm    61 ---FRNISYTKSTKDIVVVETTTEQDQLTENMENDDFARYWTQEGTMLETIPSYLMFLKMAEDGY 122

  Fly   121 SILDDAAVKD---LLNSGEKFDLVIME-------AVQTEALFGLIQHFGAETIGISSYGTDTHID 175
            ....|.|:..   |.|:..::|.|..|       |:|......:.       :.::|...|....
Worm   123 KTFRDHALPQMDYLKNNRPQYDAVFFESFFFMGKAIQEYLEIPVF-------LPVTSITHDYRFA 180

  Fly   176 ELMGN-ISPLSYNPLLLSSRTEQMDFKDRVMNVFEASVMWLHKRIVHLPSQRDLYAKYFPTARKS 239
            ||:|. :|| ||.....::....|:|::|:.|...   .:|.:.::..|:.:.|..   |:....
Worm   181 ELIGEPVSP-SYLSGYFTNFGNIMNFQERLTNTIS---YYLGQILIAFPNWKTLQD---PSKDLL 238

  Fly   240 LDEVLDSFALMLLGQHFSLSYPRPYLPNMIEVGGLHLQQKR-KVQPLAKELSEFVEQSEKGVIYF 303
            ::........:.:..:..:.:|||.|...||:||:.:..|: |.:.:.::....:::....|: .
Worm   239 VESEYHRAPYVFINSNPYIDFPRPLLSKTIEIGGITVDVKKLKSEKVDEKWDNILKKRPHNVL-I 302

  Fly   304 SMGSNIKSKDLPPSTRK---MLMQTFASVPQRVLWKFEDDQ--LPEKPDNVFISKWFPQPDILAH 363
            |.||..||..:|...::   .:|::|.:|  ..:||:|.::  .....:|:..|||.||..:||.
Worm   303 SFGSMFKSIYMPDFYKENMVKVMKSFKNV--SFIWKYESEETSFANGAENIIFSKWVPQTALLAD 365

  Fly   364 PNVKLFITHGGLLSTIESIYFGKPILGLPIFYDQHLNVQRAKQVGYGLSADIWSV-NATELTPLI 427
            ..:..|.|||||.|..|..|.|||.|..|:|.||..|.:...:....:....::: |...|...:
Worm   366 SRLSAFFTHGGLGSVNELSYLGKPALLCPLFADQIRNSKMLTRHNGSIEISKFNLENYNTLRSAL 430

  Fly   428 QELLSNPSYAAAAQTKSKLFRDQKETALERAIWWTEYVLRHKGAKHLRCASRDLDFIQFHGLDTW 492
            ..:|...||:..|:..:|....|.....|..:...|:..|...........|.:.|..::.||..
Worm   431 HSILFAESYSENAEKLAKKLEYQPTKPKELFVRHAEFAARFGEQPAQDSNLRTMGFAAYYLLDVI 495

  Fly   493 GLLIAITFVSLLIVVILIKCLQRVFVSLISKIRKNR 528
            ..|.:...:.:.:|.|:|    |..|.|:: |:..|
Worm   496 AFLTSFVLLVIFVVFIMI----RQIVKLLT-IKSKR 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35A1	NP_524314.2	egt	19..474	CDD:223071	114/491 (23%)
Ugt35A1	NP_524314.2	UDPGT	55..526	CDD:278624	118/507 (23%)
ugt-41	NP_504818.2	UDPGT	22..510	CDD:278624	117/508 (23%)
ugt-41	NP_504818.2	Glycosyltransferase_GTB_type	26..512	CDD:299143	116/506 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.810