DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35A1 and ugt-37

DIOPT Version :9

Sequence 1:	NP_524314.2	Gene:	Ugt35A1 / 41334	FlyBaseID:	FBgn0026315	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_504811.2	Gene:	ugt-37 / 184293	WormBaseID:	WBGene00017332	Length:	528	Species:	Caenorhabditis elegans

Alignment Length:	564	Identity:	151/564 - (26%)
Similarity:	248/564 - (43%)	Gaps:	84/564 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LIWLFAA-NADEGVQSSRILAVFPFPGRSQYIFAEQFMKELAHRGHNV-----TVINTFGSDKNE 75
            ||.|||. |.:   .|...|...|..|.|...|..:....|:..||||     |:|..|    ::
Worm     4 LILLFACFNVN---FSYNFLIFSPLFGHSHTTFFAKIADTLSEAGHNVTFFTPTIIRKF----SK 61

  Fly    76 PNFRVIGAKKIH----EIMAAFGN----AD----YTQTASQWQMLTMTTQFLNLL---------T 119
            .|:.......||    |.:..:||    .|    :|..:|..:|..|...|..:.         .
Worm    62 INYVKHTKHVIHLEPSEKLERYGNQMEDVDISRFWTDDSSMAEMFPMIKLFNEMFAEQAFVLGQN 126

  Fly   120 TSILDDAAVKDLLNSGEKFDLVIMEAVQTEALFGLIQHFGAET-IGISSYGTDTHIDELMGNISP 183
            ..:||:  :|::     |||::|.|.. .|..:.|:::...|| |..||...|.::...:|....
Worm   127 LDVLDE--LKEM-----KFDVMIFERF-AECAYPLLEYLEIETFIPSSSLLFDPNLLISIGEPRI 183

  Fly   184 LSYNPLLLSSRTEQMDFKDRVMNVFEASVMWLHKRIVH--LPSQRDLYAKYFPTARKSLD----E 242
            .|..||.:|..|::|...:|::|.....       |.|  ||:..   .|.|....:::|    |
Worm   184 PSTVPLPMSKFTDKMTMTERLLNAIAVP-------IFHSLLPTHE---FKSFRPPYQAIDIQKME 238

  Fly   243 VLDSFALMLLGQHFSLSYPRPYLPNMIEVGGLHLQ-QKRKVQPLAKELSEFVEQSEKGVIYFSMG 306
            .|.||  :|...:..:.||||.|...:::||:.:. :..|:..:.:|....::..:| .|..|.|
Worm   239 HLSSF--ILSNSNPYIDYPRPTLEKNVQIGGISVDVENLKIHKVNEEWDRILDMRQK-TILVSFG 300

  Fly   307 SNIKSKDLPPSTRKMLMQTFASVPQ-RVLWKFE---DDQLPEKPDNVFISKWFPQPDILAHPNVK 367
            |.:.|||:|...:|:|.:|....|: ..:||:|   .|....:.:|:..|.|.||..:||...:.
Worm   301 SVMLSKDMPVENKKILAKTMKQFPEVTFIWKYEFNDTDLFASETENIHFSSWVPQTALLADRRLT 365

  Fly   368 LFITHGGLLSTIESIYFGKPILGLPIFYDQHLNVQRAKQVGYGLSADIWSV-NATELTPLIQELL 431
            .|.||.||.|..|..|.|||.:..|||.||..|.:...:....:....:.: |..::...::.:|
Worm   366 AFFTHAGLGSVNEVSYLGKPSIMCPIFADQMRNAKMLARHNGSIEISKYDLGNGEKIEKTLRTIL 430

  Fly   432 SNPSYAAAAQTKSKLFRDQ----KETALERAIWWTEYVLRHKGAKHLRCASRDLDFIQFHGLDTW 492
            .:.||..:|:..:....:|    ||..|..|    |:..:......|...||.|.|:::..:|..
Worm   431 FDDSYRLSAEKLAHQLANQPVKPKELLLRHA----EFAAQFGRLPSLDPYSRQLSFVEYFLIDVA 491

  Fly   493 GLLIAITFVSLLIVVILIKCLQRVFVSLISKIRKNRAEASKLKT 536
            .:||   |.||||||:|.:.::|:...|...:     ::.|:||
Worm   492 AILI---FSSLLIVVVLFQIIKRLINFLPVTV-----DSRKVKT 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35A1	NP_524314.2	egt	19..474	CDD:223071	128/498 (26%)
Ugt35A1	NP_524314.2	UDPGT	55..526	CDD:278624	136/513 (27%)
ugt-37	NP_504811.2	Glycosyltransferase_GTB_type	1..504	CDD:299143	144/534 (27%)
ugt-37	NP_504811.2	UDPGT	37..510	CDD:278624	134/504 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.810