DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35A1 and ugt-40

DIOPT Version :9

Sequence 1:	NP_524314.2	Gene:	Ugt35A1 / 41334	FlyBaseID:	FBgn0026315	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_504810.2	Gene:	ugt-40 / 184292	WormBaseID:	WBGene00017331	Length:	526	Species:	Caenorhabditis elegans

Alignment Length:	550	Identity:	136/550 - (24%)
Similarity:	238/550 - (43%)	Gaps:	87/550 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 SSRILAVFPFPGRSQYIFAEQFMKELAHRGHNV-----TVINTFGSDKN---------------E 75
            |..||...|..|.|...|..:....|...||||     |:|:.|   :|               .
Worm    19 SYNILVFCPLFGHSHSTFFGRLADILTEAGHNVTLFSPTIIDEF---RNYSYTKLTKDVAYLDPS 80

  Fly    76 PNFRVIGAKKIHEIMAAFGNAD-YTQTASQWQMLTMTTQFLNLLTTS----ILDDAAVKDLLNSG 135
            |..:.||     :::|  ||.. :.|..|.:: :..||:|...:|..    :.::.|:.|.|..
Worm    81 PELKAIG-----DLIA--GNKRWWNQEFSVFE-IPQTTRFFKSITREQNNVLANNLALLDGLKQ- 136

  Fly   136 EKFDLVIMEAVQTEAL----------FGLIQHFGAETIGISSYGTDTHIDELMGNISPLSYNPLL 190
            :||||::.|:|.|.||          |.:.|....|.|.:.:.|     |.:|     .|:.|.|
Worm   137 KKFDLILFESVFTCALPLMEYLEIKSFAVAQSIAYEPITLGALG-----DTVM-----TSHIPNL 191

  Fly   191 LSSRTEQMDFKDRVMNVFEASVMWLHKRIVHLPSQRDLYAKYFPTARKSLD--EVLDSFALMLLG 253
            ::..:::|...:|::|.       |.:.::::......|.:.:....|.:.  |.|...:.:.:.
Worm   192 MAQSSDKMSLCERMLNT-------LIQAMLNVYGMTPEYYQSYTNPEKKIYTLEKLSEASFIFMN 249

  Fly   254 QHFSLSYPRPYLPNMIEVGGL--HLQQKRKVQPLAKELSEFVEQSEKGVIYFSMGSNIKSKDLPP 316
            .:..|.:||..:...|::||:  :|...:....|.:|..:.:...|| .:..|.||.|.|:|:|.
Worm   250 SNPFLDFPRATITKNIQIGGISVNLDTLKSSGKLTEEWDQILNLREK-TLLVSFGSVILSQDMPF 313

  Fly   317 STRKMLMQTFASVPQ-RVLWKFEDDQLPEKPD---NVFISKWFPQPDILAHPNVKLFITHGGLLS 377
            :.:..|......:.. ..:||:|.|...|..:   |:..|||.||.::||.|.:..|:|||||.|
Worm   314 AYKVGLTNAMKQLNDVTFIWKYEGDDKKEFANGIKNIHFSKWVPQRELLADPRLSAFMTHGGLGS 378

  Fly   378 TIESIYFGKPILGLPIFYDQHLNVQRAKQVGYGLSADIWSV-NATELTPLIQELLSNPSYAAAAQ 441
            ..|..|||||.:..|:..||..|.:..::....:....:.: |...:....:::|.:.||..:|:
Worm   379 VNEVSYFGKPTIMCPLSGDQMRNAKMLERHNGSIEFSKYDLHNEKVVANAFRKILYDESYTLSAK 443

  Fly   442 TKSKLFRDQKETALERAIWWTEYVLRHKGAKHLRCASRDLDFIQFHGLDTWGLLIAITFVSLLIV 506
            ..|:..:.|.....|..:...|:..|......|...||.:.|||:       .||.|.|:.|.:|
Worm   444 RLSEHLQFQPVKPKELFLKHVEFAARFGKLPSLDPYSRQMGFIQY-------FLIDIAFIVLTVV 501

  Fly   507 VILIKCLQRVFVSLISKIRKNRAEASKLKT 536
            :.::..|..|...:.|.::      :|:||
Worm   502 LTIVSVLYFVLKFVASCLK------AKIKT 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35A1	NP_524314.2	egt	19..474	CDD:223071	118/486 (24%)
Ugt35A1	NP_524314.2	UDPGT	55..526	CDD:278624	126/514 (25%)
ugt-40	NP_504810.2	YjiC	22..447	CDD:224732	112/454 (25%)
ugt-40	NP_504810.2	Glycosyltransferase_GTB_type	<247..503	CDD:299143	72/263 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.810