DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt35A1 and ugt-65

DIOPT Version :9

Sequence 1:	NP_524314.2	Gene:	Ugt35A1 / 41334	FlyBaseID:	FBgn0026315	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_502373.3	Gene:	ugt-65 / 184205	WormBaseID:	WBGene00008583	Length:	509	Species:	Caenorhabditis elegans

Alignment Length:	540	Identity:	123/540 - (22%)
Similarity:	230/540 - (42%)	Gaps:	93/540 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 LIGLIWLFA-----ANADEGVQSSRILAVFPFPGRSQYIFAEQFMKELAHRGHNVTVINTFGSDK 73
            ||.:|:|.|     :|.      ||||.:..|..:|..:......:.|...||:|::. |..:::
Worm     7 LITIIFLLAHFLTTSNC------SRILFLNMFNSKSHALTMMPLAERLFDDGHDVSMY-TISANR 64

  Fly    74 NEPNFRVIGAKKIHEIMAAFGNADYTQTAS-----------QWQMLTMTTQFLNLLTTSILD--- 124
            .:     |.:||: :|:.:......|..|:           .::|......:...:....|:
Worm    65 LK-----IPSKKV-KILESLVKGSSTDDAAPDTGGVSRIFWSYEMTPYVGAWCYEIGLYYLEEGR 123

  Fly   125 DAAVKDLLNSGEKFDLVIMEAVQTEALFGLI------QHFGAETIGISSYGTDTHIDELMGNISP 183
            |..:.::|  ...:||.:::...| :|.|.|      .|    :..|.::.| |.:..:..|:..
Worm   124 DEQLDEVL--ATPYDLAVVDETYT-SLQGSIALKLKEDH----STKIITFAT-TELMPVASNMRG 180

  Fly   184 LSYNPL------LLSSRT---EQMDFKDRVMNVFEASVMWLHK------------RIVHLPSQRD 227
            .:.||:      ||||..   .:..|..|...:||..:..::.            :::.|.|...
Worm   181 YARNPVTVPNTFLLSSEVYEGNRFAFLTRTRRIFEYFIDQIYSGPVASLYSEASGKLLGLTSATK 245

  Fly   228 LYAKYFPTARKSLDEVLDSFALMLLGQHFSLSYPRPYLPNMIEVGGLHLQQKRKVQPLAKELSEF 292
              :|.|..:..::::..|:|           |:.:|...::|.||. |......   |..|..:|
Worm   246 --SKTFQNSILTVNDFPDTF-----------SFVQPRGNDLIRVGE-HCYSSAN---LPSEFRDF 293

  Fly   293 VEQS-EKGVIYFSMGSNIKSKDLPPSTRKMLMQTFASVPQ-RVLWKFEDDQLPEKPDNVFISKWF 355
            ||.| .||.||.:|||.:..:|.|..|.:..::....... ||:|..:.:....| .:|....|.
Worm   294 VEDSMSKGTIYVAMGSYLNLEDGPKGTVEAFIEALNYFKDYRVIWSHKGNVTGAK-CHVKSVNWA 357

  Fly   356 PQPDILAHPNVKLFITHGGLLSTIESIYFGKPILGLPIFYDQHLNVQRAKQVGYGLSADIW--SV 418
            ||.::|||.....|||||||.|..|.:..|.|:|.||.:.||..|..|.  |..|::..::  ::
Worm   358 PQKELLAHEKTVAFITHGGLKSAKEGVCSGVPMLFLPFYGDQPRNAHRF--VTNGIAEALYKKAI 420

  Fly   419 NATELTPLIQELLSNPSYAAAAQTKSKLFRDQKETALERAIWWTEYVLRHKGAKHLRCASRD--L 481
            .:.::...:::||.:|||..........:.|...::|:...:....|||...:::.:...|.  :
Worm   421 TSLDIQQKLEKLLVDPSYKNNVMKVLSYYLDAPISSLDLGAFHISQVLRRTESQYSKFKRRSIFM 485

  Fly   482 DFIQFHGLDTWGLLIAITFV 501
            :.:|:..||.:.:::.|.|:
Worm   486 NHLQYLNLDIFLVILVILFI 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35A1	NP_524314.2	egt	19..474	CDD:223071	114/504 (23%)
Ugt35A1	NP_524314.2	UDPGT	55..526	CDD:278624	111/494 (22%)
ugt-65	NP_502373.3	egt	<300..505	CDD:223071	56/207 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.010