DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35A1 and ugt-7

DIOPT Version :9

Sequence 1:	NP_524314.2	Gene:	Ugt35A1 / 41334	FlyBaseID:	FBgn0026315	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_504343.2	Gene:	ugt-7 / 182577	WormBaseID:	WBGene00015739	Length:	530	Species:	Caenorhabditis elegans

Alignment Length:	533	Identity:	136/533 - (25%)
Similarity:	229/533 - (42%)	Gaps:	75/533 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 RILAVFPFPGRSQYIFAEQFMKELAHRGHNVTV-----INTFGSDK--NEPNFRVIGAKKIHEIM 90
            :.|.:.|....|...|.......||..||.|.|     :......|  ..|:.::|.    :|..
Worm    17 KYLIISPIYSYSHVKFMSNIADTLADHGHEVVVFQQQIVEALRDKKVIKNPDIKIIN----YEAN 77

  Fly    91 AA----FGNADYTQTASQW------------QMLTMTTQFLNLLTTSILDDAAVKDLLNSGEKFD 139
            .|    :.|...:.....|            |.....::.|..:...:.:|.::..:|.| |.||
Worm    78 TAGKEFYRNRPKSSVTKYWTTNQAANPSAADQFAEAMSKDLEHMCLQVFEDKSLHTMLKS-EHFD 141

  Fly   140 LVIMEAVQTEALF-GLIQHFGAETIGISSYGTDTHIDELMGNISPLSYNPLLLSSRTEQMDFKDR 203
            :::.|......|: |......:..:.::|...|. :...:|..|.|::.|...|...|:....||
Worm   142 VLLAEPFDPCGLYLGDYLKIPSTIVAMASSRIDP-VQWALGQPSGLNFIPGPDSKYGEESGVWDR 205

  Fly   204 VMNVFEASVMWLHKRIVHLPSQRDLYAKYFPTAR-------KSLDEVLDSFALMLLGQHFSLSYP 261
            :.||:   :.::..|:.     |.:|.......|       :::||::...|.:....:..|.:|
Worm   206 INNVW---MFFMRTRMF-----RAVYWNLLDKLRFKTGLEIRNIDEIVAESAYLFYNSNPYLDFP 262

  Fly   262 RPYLPNMIEVGGLHLQQKR-KVQPLAKELSEFVEQSEKGVIYFSMGSNIKSKDLPPSTRKMLMQ- 324
            .|.|...:.:||..:.... |.:.|.:.|...: |.....::.|.||.|:|.|:|...:..:::
Worm   263 FPSLTKCVPIGGFSMNTTNWKSENLPENLKNIL-QKRPNTVFISFGSVIRSADMPQEYKNAIIEV 326

  Fly   325 -------TFASVPQRVLWKFEDDQLPEK----PDNVFISKWFPQPDILAHPNVKLFITHGGLLST 378
                   ||       :||:||::..|.    |:||.:.||.|||.:||...|.||||||||.|.
Worm   327 TKLMSDVTF-------IWKYEDEKDEEMRGNIPENVHLMKWLPQPALLADSRVSLFITHGGLGSI 384

  Fly   379 IESIYFGKPILGLPIFYDQHLNVQRAKQVGYGLSADIWS----VNATELTPLIQELLSNPSYAAA 439
            :|..|.|||.:.:|:|:||.:|.:..::.|   .|:::|    .||.:|..:||.::.||.|.|.
Worm   385 MEVAYSGKPAIVIPLFFDQPMNGEMLRRHG---GAEVYSKFELSNAKKLKKVIQNMIQNPKYLAN 446

  Fly   440 AQTKSKLFRDQKETALERAIWWTEYVLRHKGAKHLRCASRDLDFIQFHGLDTWGLLIAITFVSLL 504
            |:..|.|.:.|....:||.:...|:....|....|...||.|:|.||..||....|:.:..:|.|
Worm   447 AKKLSNLLQKQPINPIERLVKHAEFAAEFKKLPELDPYSRHLNFFQFFFLDIVATLLILFMLSAL 511

  Fly   505 IV--VILIKCLQR 515
            .|  :..:.|..|
Worm   512 FVYWITYVICSVR 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35A1	NP_524314.2	egt	19..474	CDD:223071	121/488 (25%)
Ugt35A1	NP_524314.2	UDPGT	55..526	CDD:278624	132/511 (26%)
ugt-7	NP_504343.2	egt	1..477	CDD:223071	120/484 (25%)
ugt-7	NP_504343.2	UDPGT	27..521	CDD:278624	132/518 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.810