DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35A1 and ugt-27

DIOPT Version :9

Sequence 1:	NP_524314.2	Gene:	Ugt35A1 / 41334	FlyBaseID:	FBgn0026315	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_491436.1	Gene:	ugt-27 / 182508	WormBaseID:	WBGene00015694	Length:	526	Species:	Caenorhabditis elegans

Alignment Length:	517	Identity:	138/517 - (26%)
Similarity:	221/517 - (42%)	Gaps:	53/517 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 VQSSRILAVFPFPGRSQYIFAEQFMKELAHRGHNVT-------VINTFGSDKNEPNFRVIGAKKI 86
            |.|..:|...|....|...|..:....|...|||||       |..|.....:.....:|..|..
Worm    16 VNSINVLVYSPAFAASHTNFMARLADTLTEAGHNVTFLVPIVDVARTKQLGVHVTTDVIIVEKDE 80

  Fly    87 H---------EIMAAFGNADYTQTAS-----QWQMLTMTTQFLNLLTT-SILDDAAVKDLLNSGE 136
            |         :.|.|:...: |.:::     ||....|.....|||.. .|||..       ...
Worm    81 HTTQESVPFDDSMEAYWTEE-THSSNVGESFQWFFDGMKLGCENLLRRHEILDQL-------KSR 137

  Fly   137 KFDLVIMEAVQTEALFGLIQHFG-AETIGISSYGTDTHIDELMGNISPLSYNPLLLSSRTEQMDF 200
            .||:.|:|.:....| ||.:... .:||..||.....::...:|.....||.|.|:|:..:.|..
Worm   138 NFDVAIVEPLSVCGL-GLAKKLEIGKTILASSCAYYDYLFRHIGEPDVHSYLPSLMSTTGDVMTT 201

  Fly   201 KDRVMN--VFEASVMWLHKRIVHLPSQRDLYAKYFPTARKSLDEVLDSFALMLLGQHFSLSYPRP 263
            .:|:.|  |.||....::|.   ..|::.:|.|:|........::|.:.:|.....:..|.:|||
Worm   202 FERLENHRVAEAMATAMYKM---FDSEKAIYRKHFGDEIPDWRDLLPAASLYFTNSNPYLDFPRP 263

  Fly   264 YLPNMIEVGGLHLQQKR-KVQPLAKELSEFVEQSEKGVIYFSMGSNIKSKDLPPSTRKMLMQTFA 327
            .|...:.:||:.:..|: |.|.|.||.:..:.:....:: .|.||.|.|..:....:|.|::...
Worm   264 ILQKTVSIGGISVDTKKIKSQELDKEWNHILNKRNLNML-ISFGSMIHSSHMLDDAKKNLIKVIK 327

  Fly   328 SVPQ-RVLWKFE--DDQLPEKPDNVFISKWFPQPDILAHPNVKLFITHGGLLSTIESIYFGKPIL 389
            |.|. ..:||:|  |.......||::.|||.||..:|....:..|:|||||.||.|..:||||.:
Worm   328 SEPNVTFIWKYETNDTSFAFGIDNIYFSKWVPQSKLLNDARLTAFLTHGGLGSTNELAHFGKPAV 392

  Fly   390 GLPIFYDQHLNVQRAKQVGYGLSADIWSVNATEL------TPLIQELLSNPSYAAAAQTKSKLFR 448
            .:|||.||:.|....::.|..:     .|..|||      :..::.:|.:.:|...|...:.|.:
Worm   393 MVPIFGDQYRNGHMLQRHGCAI-----IVQKTELSNWKIVSSAVKSVLYDENYKKNAAHLADLLQ 452

  Fly   449 DQKETALERAIWWTEYVLRHKGAKHLRCASRDLDFIQFHGLDTWGLLIAITFVSLLIVVILI 510
            :|.....|..:.:.|:|.|......:....|.|:|||.:.||.:.:.:...|:..||:..||
Worm   453 NQPVKPKEIVVKYVEFVARFGPFPEMDAYGRQLNFIQRNLLDVYLIELFGHFLFFLIIFCLI 514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35A1	NP_524314.2	egt	19..474	CDD:223071	126/479 (26%)
Ugt35A1	NP_524314.2	UDPGT	55..526	CDD:278624	132/491 (27%)
ugt-27	NP_491436.1	UDPGT	21..500	CDD:278624	131/496 (26%)
ugt-27	NP_491436.1	egt	<230..478	CDD:223071	71/253 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.810