DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35A1 and ugt-57

DIOPT Version :9

Sequence 1:	NP_524314.2	Gene:	Ugt35A1 / 41334	FlyBaseID:	FBgn0026315	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_509182.1	Gene:	ugt-57 / 180969	WormBaseID:	WBGene00017154	Length:	558	Species:	Caenorhabditis elegans

Alignment Length:	570	Identity:	130/570 - (22%)
Similarity:	233/570 - (40%)	Gaps:	132/570 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 ILLIGLIWLFAANADEGVQSSRILAVFPFPGRSQY---IFAEQFMKELAHRGHNVTVINTFGSDK 73
            |||:||..:        |.|..|| || ..|.:|:   || |...::||.|.|||..|......:
Worm     5 ILLLGLTQI--------VTSLNIL-VF-LLGTNQFERNIF-EFLAQQLALRHHNVISIKPVLIPE 58

  Fly    74 N----EPNFRVIGAKKIHEIM---------AAFGNADYTQT---------------ASQWQMLTM 110
            .    :|...::..|.|..::         .|..||.:..|               ||.:::|..
Worm    59 EPRLVKPKLHLVREKVIKNVLNKDLFKPLEDAVPNAAWRSTYDFDNYLEPYYKAHNASCYKLLNS 123

  Fly   111 T------------------TQFLNLLT------TSILDDAAVKD--LLNSGEKFDLVIMEAVQTE 149
            .                  ...||.||      |...|...:.|  |:.:|...||:...:
Worm   124 NLVDSLKKESLDLAIVYSGNPCLNALTHLVAVPTIYFDTEGLTDETLIAAGAPIDLLTPPS---- 184

  Fly   150 ALFGLIQH-FGAETIG---ISSYGTDT-HIDELMGNISPLSYNPLLLSSRTEQMDFKDRVMNVFE 209
                   | |.||:.|   ::.|.... :..|::..:. |.....|:|||...:|  :.:.|:|.
Worm   185 -------HCFIAESKGYPILNLYKNSVCYFQEMIAQLG-LPAVSSLVSSRHRLLD--EPITNIFR 239

  Fly   210 ASVMWLHKRIVHLPSQRDL---YAKYFPTARKSLDEVLDSFALMLLGQHFSLSYPRPYLPNMIEV 271
            .... :.||..:.|:...|   .|.||    .:.|.:|:.              ||....|:|.|
Worm   240 TDYT-IKKRFKNFPNVNTLKQQSAAYF----VNTDPLLEP--------------PRALPLNVIPV 285

  Fly   272 GGLHLQQKRKVQPLAKELSEFVEQSEKGVIYFSMGSNIKSKDLPPSTRKMLMQTFASV-PQRVLW 335
            ||||:...:   ||....:..:..:::|:|..|.|:...|..:.....|.:::...:: ..|:.|
Worm   286 GGLHIDHPK---PLFSPWNTTIASAKEGLIIVSFGTQADSSKMSEYHAKAILKALTNLNDYRIYW 347

  Fly   336 K------FEDDQLPEKPDNVFISKWFPQPDILAHPNVKLFITHGGLLSTIESIYFGKPILGLPIF 394
            :      .:...:.:.|.::.::.:.||.|:|||.:.|||:|:||:.|.:|::..|.||:|:|::
Worm   348 RIGPNMHLDGIDIEKIPKHINLTTFIPQNDLLAHKSCKLFVTNGGMSSVMEAVAHGVPIVGVPLY 412

  Fly   395 YDQHLNVQRAKQVGYGLSADIWSVNATELTPLIQELLSNPSYAAAAQTKSKLFRDQKETALERAI 459
            .....|:|:....|.|:..|...:|...|...::::|.:..|...|:..||.|:.:..:....|:
Worm   413 GSNRYNLQKVSNKGLGIVIDKDDLNEISLYGAMKKVLESAKYKNTAKEMSKEFKSRTTSPFAAAL 477

  Fly   460 WWTEYVLRHKGAKHLRCASRDLDFIQFHGLDTWGLLIAITFVSLLIVVIL 509
            ...:::.||....:::.|        |..:.|     .:.|..||::::|
Worm   478 HVIDHIGRHHSFAYMQPA--------FQPIYT-----RVDFYLLLLIILL 514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35A1	NP_524314.2	egt	19..474	CDD:223071	118/526 (22%)
Ugt35A1	NP_524314.2	UDPGT	55..526	CDD:278624	114/524 (22%)
ugt-57	NP_509182.1	GT1_Gtf-like	<168..477	CDD:340817	80/344 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910