DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35A1 and ugt-4

DIOPT Version :9

Sequence 1:	NP_524314.2	Gene:	Ugt35A1 / 41334	FlyBaseID:	FBgn0026315	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_001041203.1	Gene:	ugt-4 / 179754	WormBaseID:	WBGene00013905	Length:	535	Species:	Caenorhabditis elegans

Alignment Length:	537	Identity:	135/537 - (25%)
Similarity:	229/537 - (42%)	Gaps:	85/537 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 VQSSRILAVFPFPGRSQYIFAEQFMKELAHRGHNVT-----VINTFGSDK--NEPNFRVI----- 81
            |:|.:.|.:.|..|.|...|......:||..||.||     ||..:...|  |.....||
Worm    17 VESYKFLVISPVYGYSHMKFMAIIANQLADEGHQVTYFQPFVIEAYLDHKLLNNSLIDVINYWHD 81

  Fly    82 --GAKKI---HEIMAAFGNADYTQTASQ-WQMLTMTTQFLNLLTTSILDDAAVKDLLNSGEKFDL 140
              |.:.|   :::..|:.::.|....|. :.|..........:...|..|:.:..:|.. :.||:
Worm    82 EEGRRHIPPSNDLHDAWYSSKYQSALSAVFDMPQFLVSAWEHMCRKIFQDSELHKILKD-KDFDV 145

  Fly   141 VIMEA-----------VQTEALFGLIQHFGAETIGISSYGTDTHIDELMGNISPLSYNPLLLSSR 194
            ||.|.           :|::::..:..  |:..|.|    ||.     :|..|.|.|.|...|..
Worm   146 VIAETFDFCGLYLADYIQSKSIVSVFT--GSRLIAI----TDP-----LGEPSSLHYIPAPSSDN 199

  Fly   195 -TEQMDFKDRVMNVFEASVM---------WLHKRIVHLPSQRDLYAKYFPTARKSLDEVLDSFAL 249
             .......||:.:::...|.         |.:.:|..|...:..:.|      |.|.:|...||
Worm   200 FGSSASIFDRINDLYHKYVFGSGYSIIFDWQYNQIARLTHGKVRHWK------KILKDVTYHFA- 257

  Fly   250 MLLGQHFSLSYPRPYLPNMIEVGGLHLQQKRKVQPLAKELSEFVEQSEKGVIYFSMGSNIKSKDL 314
               ..:..|.:..|.:..:|.:||..:.  :.:|....:..:.:.......:|.|.||.:|:|.:
Worm   258 ---NSNPYLDFAAPTISKVIPIGGYDMD--KSIQTKIPDEFDSILNERSLTVYVSFGSMVKAKFM 317

  Fly   315 PPSTRKMLMQTFASVPQRV--LWKFED-------DQLPEKPDNVFISKWFPQPDILAHPNVKLFI 370
            |.|.::.:::.|.:..|.:  |||:||       ::||:   ||.:..||||..:||...|||||
Worm   318 PESYKEAMLRMFTANTQNITFLWKYEDPTDIFFKNRLPK---NVILKDWFPQRALLADKRVKLFI 379

  Fly   371 THGGLLSTIESIYFGKPILGLPIFYDQHLNVQRAKQVGYGLSADIWSVNA----TELTPLIQELL 431
            |||||.||:|..|..||.:.:|:..:|..|.:...:.|   ||:|:|.:.    .:|..|:|::|
Worm   380 THGGLGSTMELAYAAKPAIVIPLIAEQPDNGKMLARHG---SAEIYSKHDIPHWEKLNRLLQKML 441

  Fly   432 SNPSYAAAAQTKSKLFRDQKETALERAIWWTEYVLRHKGAKHLRCASRDLDFIQFHGLDTWGLLI 496
            .:.||..||...:::..:|.....|..|..:|..........|..:.:|:..|:|:.||   ::.
Worm   442 QHSSYQKAADRLARVLSNQPIKPRELMIKHSEMAAMFGKMPELTPSVQDMSIIEFYNLD---IIF 503

  Fly   497 AITFVSLLIVVILIKCL 513
            ....:|:...|:|.|.|
Worm   504 LFLIISIGTSVLLWKFL 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35A1	NP_524314.2	egt	19..474	CDD:223071	124/496 (25%)
Ugt35A1	NP_524314.2	UDPGT	55..526	CDD:278624	128/511 (25%)
ugt-4	NP_001041203.1	egt	1..473	CDD:223071	123/485 (25%)
ugt-4	NP_001041203.1	UDPGT	21..500	CDD:278624	126/508 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.810