DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35A1 and ugt-2

DIOPT Version :9

Sequence 1:	NP_524314.2	Gene:	Ugt35A1 / 41334	FlyBaseID:	FBgn0026315	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_505672.2	Gene:	ugt-2 / 179450	WormBaseID:	WBGene00007073	Length:	531	Species:	Caenorhabditis elegans

Alignment Length:	568	Identity:	148/568 - (26%)
Similarity:	251/568 - (44%)	Gaps:	84/568 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LLIGLIWLFAANADEGVQSSRILAVFPFPGRSQYIFAEQFMKELAHRGHNVTVINTFGSDKNEPN 77
            ||:.|.:....|    |.:...|.|.|..|.|...|..:....||:..||||::.|: ..::...
Worm     5 LLVFLFFALYCN----VLAYNYLVVAPVFGYSHMKFMNKVADTLANGKHNVTLLQTY-IYEHWGK 64

  Fly    78 FRVIGAKKIHEIMAAFGNADY---------TQTASQWQML------------TMTTQFL-----N 116
            .|::..|.|..|       ||         .|:||.::..            .|...|:     .
Worm    65 IRIVKNKNIEII-------DYHNSENVPSNEQSASAFKFFWDNEIVNNPITGAMAPMFILYNEFK 122

  Fly   117 LLTTSILDDAAVKDLLNSGEKFDLVIMEAVQTEALFGLIQHFGAETIGISSYGTDTHIDELMGNI 181
            .:...||.|..:...:.| .|||..:.|:....:|: |..|.....:.:.|...:......:|..
Worm   123 PMCDRILTDKELHQWILS-NKFDGYVAESFDFCSLY-LGDHLKLNLLPMFSTIKNVPGSHAIGEP 185

  Fly   182 SPLSYNPLLLSSRTEQMDFKDRVMNVFEASVMWLHKRIVHLPSQRDLYAKYFPTARKSLD----- 241
            |.|:|.|.|.::........||:.::  .:....|...      .:|:.:.:..|...|:
Worm   186 SLLNYAPSLYTNFGSDQTVWDRIQDI--TAFTSFHYAF------SNLFERQYRQAYDLLNGDVRT 242

  Fly   242 --EVLDSFALMLLGQHFSLSYPRPYLPNMIEVGGLHLQQKRKVQPLAKELSEFVEQSEKGVIYFS 304
              |:|.:........:..:.:..|.|...:|:||..:.....:. |.:|..:.:: ..|..:..|
Worm   243 WREILQTATYFFYNNNPYIGFAMPTLEKSVEIGGFTIDPPHDLS-LNEEFDKLLD-LRKSTVLIS 305

  Fly   305 MGSNIKSKDLPPSTRKMLMQTFASVPQRV-LWKF--EDDQLPEK-PDNVFISKWFPQPDILAHPN 365
            .|:.::|.|:|.:.:..|::.||.:|... :||:  ||.:..:. .:|||:.||.|||.:||.|.
Worm   306 FGTVVQSADMPENFKSGLIKMFAKLPDTTFIWKYEVEDAEFSKTLSENVFLKKWIPQPALLADPR 370

  Fly   366 VKLFITHGGLLSTIESIYFGKPILGLPIFYDQHLNVQRAKQVGYGLSADIWSV-NATELTPLIQE 429
            :.||||||||.||:|..|.|||.|.:|||.||.||.:...:.|..:|.|.:.: |..:||..::|
Worm   371 LNLFITHGGLGSTLEVAYAGKPSLMIPIFGDQMLNAKMLSRHGGAISYDKYELENYEKLTETVKE 435

  Fly   430 LLSNPSYAAAAQTKSKLFRDQ----KETALERAIWWTEYVLRHKGAKHLRCASRDLDFIQFHGLD 490
            .:||..|...|...:::..:|    |:..|:.|    |:..:......|...|...:||:::.||
Worm   436 AISNKEYNKKALLLAEILHNQPIDPKQNLLKHA----EFTAKFGRVHALEPYSVHYNFIKYYMLD 496

  Fly   491 TWGLLIAITFVSLLIVV-ILIKCLQRVFVSLISKIRKNRAEASKLKTQ 537
            .:.::| |.|:|:|.|: ::||.:.|       ||.|     ||.||:
Worm   497 AYAIII-IFFLSILYVLNLIIKFVYR-------KIFK-----SKRKTE 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35A1	NP_524314.2	egt	19..474	CDD:223071	123/496 (25%)
Ugt35A1	NP_524314.2	UDPGT	55..526	CDD:278624	132/513 (26%)
ugt-2	NP_505672.2	egt	15..498	CDD:223071	129/510 (25%)
ugt-2	NP_505672.2	UDPGT	31..530	CDD:278624	137/535 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5496
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.760