DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35A1 and ugt-9

DIOPT Version :9

Sequence 1:	NP_524314.2	Gene:	Ugt35A1 / 41334	FlyBaseID:	FBgn0026315	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_504312.1	Gene:	ugt-9 / 178883	WormBaseID:	WBGene00020587	Length:	533	Species:	Caenorhabditis elegans

Alignment Length:	576	Identity:	146/576 - (25%)
Similarity:	230/576 - (39%)	Gaps:	104/576 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LGILLIGLIWLFAANADEGVQSSRILAVFPFPGRSQYIFAEQFMKELAHRGHNVTVI-------- 66
            |.|||:..:          |....||...|..|.|...|..|....:|..||||||.
Worm     7 LSILLVISL----------VSCKNILVYNPIFGYSHAKFVSQLANIIADHGHNVTVFQPFHIALK 61

  Fly    67 NTFGSDKNEPNFRVIGAKKIHEIMAAFGNADYTQTASQ--------WQMLTMTTQFLNLL----- 118
            ||.|..||: |..:|.....|          |.:...:        |....|....|:..
Worm    62 NTDGLIKNK-NIEIINYYPDH----------YAELLKKKTPTFPDFWDSHLMNNPVLSSFLMPKA 115

  Fly   119 --------TTSILDDAAV-KDLLNSGEKFDLVIMEAVQTEALFGLIQHFGAETIGISSYGTDTHI 174
                    ||.:..|..: .||.|  ..||:::.|..:. |.|.:.......:|.:.|......|
Worm   116 LGGEFEQTTTQLFQDQKILNDLKN--RNFDVLLAETFEI-AGFYIADLLEIPSIPLMSAVRLPII 177

  Fly   175 DELMGNISPLSYNPLLLSSRTEQMDFKDRVMNVFEASVMW--------------LHKRIVH-LPS 224
            |...|..|.|.|.|...|....:..|.||:.:::.. ..|              :.|.|.| :|.
Worm   178 DSAFGQPSILGYFPQQYSKVAPEAGFLDRLNDLYRI-FFWNLTTQRLCQFQNDFIQKAIGHPVPH 241

  Fly   225 QRDLYAK---YFPTARKSLDEVLDSFALMLLGQHFSLSYPRPYLPNMIEVGG--LHLQQKRKVQP 284
            .|||..:   |...:...||     ||:             |....::.|||  :.|::.|.|..
Worm   242 WRDLVKESPIYITNSNSYLD-----FAV-------------PTTATIVHVGGITIDLEKMRHVAA 288

  Fly   285 LAKELSEFVEQSEKGVIYFSMGSNIKSKDLPPSTRKMLMQTFASVPQ-RVLWKFEDDQLP---EK 345
            |.:|....:.:.| ..::.|.||.|:|.::|.:.:..:::.|.|:|. ..:||:|.|.:.   ..
Worm   289 LTEEYENILAERE-STVFISFGSVIRSYEMPDNFKAGIIKMFKSLPDVTFIWKYEKDDVKFQNRL 352

  Fly   346 PDNVFISKWFPQPDILAHPNVKLFITHGGLLSTIESIYFGKPILGLPIFYDQHLNVQRAKQVGYG 410
            |.||.:.||.|||.:||...||||:|||||.||:|..|.|||.|.:|||.||..|.....:.|..
Worm   353 PKNVHLKKWVPQPSLLADKRVKLFVTHGGLGSTMEVAYTGKPALMVPIFGDQPNNADMLARHGGA 417

  Fly   411 LSADIWSV-NATELTPLIQELLSNPSYAAAAQTKSKLFRDQKETALERAIWWTEYVLRHKGAKHL 474
            ::.|.:.: :..:||..::::::|..|...||...|:...|........:...|:.:.....:..
Worm   418 VAYDKFDLADGEKLTKTVRDMVTNSKYEVNAQELLKVLSKQPIDPKLNLMKHLEFAMEFPKHRSQ 482

  Fly   475 RCASRDLDFIQFHGLDTWGLLIAITFVSLLIVVILIKCLQRVFVSLISKIRKNRAE 530
            ..|......|..:.||..|:|...:...|.::..::..|:::.     .:||.:.|
Worm   483 VPAINRTGLIAHYYLDVIGVLTLASIFGLFVIFKILNILRKMI-----SLRKVKRE 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35A1	NP_524314.2	egt	19..474	CDD:223071	131/509 (26%)
Ugt35A1	NP_524314.2	UDPGT	55..526	CDD:278624	131/525 (25%)
ugt-9	NP_504312.1	egt	20..462	CDD:223071	129/475 (27%)
ugt-9	NP_504312.1	UDPGT	30..532	CDD:278624	136/540 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.810