DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35A1 and ugt-44

DIOPT Version :9

Sequence 1:	NP_524314.2	Gene:	Ugt35A1 / 41334	FlyBaseID:	FBgn0026315	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_501933.1	Gene:	ugt-44 / 177939	WormBaseID:	WBGene00008486	Length:	542	Species:	Caenorhabditis elegans

Alignment Length:	545	Identity:	139/545 - (25%)
Similarity:	248/545 - (45%)	Gaps:	57/545 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LIWLFAANADEGVQ-SSRILAVFPFPGRSQYIFAEQFMKELAHRGHNVTVINTF---GSDKNEPN 77
            ||.::.:....|:: ..::|...|..|.|...|.......|...|:|||::...   |.....|.
Worm    10 LIIVYYSQTINGIERPKKVLVFMPISGHSHLKFMGTIANILQDEGYNVTLLLPILDEGLRDTTPL 74

  Fly    78 FRVIG----AKKIHEIMAAFGNADYTQTASQ---WQM-------LTMTTQFLNLLTTSILDDAAV 128
            .|.|.    .::..|::.|  ||.:.....:   |.|       |.:.|:..|:...|..:....
Worm    75 VRKIKNRILVEQSEELIEA--NAQFRAGGGRENTWVMNSGIIGFLKLGTKVANICKASCKNVFQN 137

  Fly   129 KDLLN--SGEKFDLVIMEAVQTEALFGLIQHFGAETIGISSYGTDTHIDELMGNIS-----PLSY 186
            :||:|  ..::||:.|.|.:.| ..|.|..|.|.||    :..||:|:...:..|:     ..||
Worm   138 EDLINYLRDQRFDVAISEPLYT-CGFALFDHLGIET----TISTDSHLGLEVSKIAHGASISTSY 197

  Fly   187 NPLLLSSRTEQMDFKDRVMNVFEASVMWLHKRIVH---LPSQRDLYAKYFPTARKSLDEVLDSFA 248
            .|.:.||.:|:|....|..|..|:...:.....::   |.....:|..     .|...|:....|
Worm   198 LPAVFSSGSERMTLIGRAKNYVESYFNYYFNSKIYENELAGIEGIYKN-----GKGWRELSRKNA 257

  Fly   249 LMLLGQHFSLSYPRPYLPNMIEVGGLH---LQQKRKVQPLAKELSEFVEQSEKGVIYFSMGSNIK 310
            .|.:..:..:..|.|.....||:||:.   ::|:|    |.:|....:...:|.|: .|.|:|.|
Worm   258 YMFVNSNPQMDIPSPRTSKFIEIGGISSGPVKQER----LPEEYDRVLSLRKKNVL-ISFGTNAK 317

  Fly   311 SKDLPPSTRKMLMQTFASVPQRV-LWKFED------DQLPEKPDNVFISKWFPQPDILAHPNVKL 368
            |..:....::.|::||.|:|... :||:|:      .|..::.:||.::.|.||..:||.|.:.|
Worm   318 SMFMSDDMKESLIKTFESMPDTTFIWKYENTTVDIVKQYNKRINNVMLTDWMPQTALLADPRLTL 382

  Fly   369 FITHGGLLSTIESIYFGKPILGLPIFYDQHLNVQRAKQVGYGLSADIWSV-NATELTPLIQELLS 432
            |:|||||.||.|..:.|||.:.:|:|.||..|.:..::....|....:.: |..::...|:::|:
Worm   383 FVTHGGLGSTNEVAFSGKPSIMVPVFGDQTRNARMLERHEVALVLTKYDLTNFKKVRGTIRKMLN 447

  Fly   433 NPSYAAAAQTKSKLFRDQKETALERAIWWTEYVLRHKGAKHLRCASRDLDFIQFHGLDTWGLLIA 497
            :.||:..|:..:::.|:|.|:..|..|.:..:|.|......|...:.::.||:|:.:|...:| :
Worm   448 DKSYSMKAEKLAQMLRNQPESPKEIFIKYFNFVARFGKPHGLDSYAAEMSFIEFYYIDFMAIL-S 511

  Fly   498 ITFVSLLIVVILIKCLQRVFVSLIS 522
            |..|:|.::|..:........:|:|
Worm   512 IFSVALYMIVSKVLRASHNLTNLVS 536

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35A1	NP_524314.2	egt	19..474	CDD:223071	125/493 (25%)
Ugt35A1	NP_524314.2	UDPGT	55..526	CDD:278624	131/506 (26%)
ugt-44	NP_501933.1	UDPGT	27..510	CDD:278624	129/499 (26%)
ugt-44	NP_501933.1	egt	<250..519	CDD:223071	78/274 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.810