DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt35A1 and ugt-24

DIOPT Version :9

Sequence 1:	NP_524314.2	Gene:	Ugt35A1 / 41334	FlyBaseID:	FBgn0026315	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_500931.3	Gene:	ugt-24 / 177380	WormBaseID:	WBGene00016762	Length:	528	Species:	Caenorhabditis elegans

Alignment Length:	514	Identity:	142/514 - (27%)
Similarity:	235/514 - (45%)	Gaps:	67/514 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 LAHRGHNVT----VINTFGSDKN----------EPNFRVI-GAKKIHEIMAAFGNADYTQTASQW 105
            |...|||||    :|.:...||:          ||:..|: ...||.:...:....|.|..::..
Worm    44 LTDAGHNVTIFRPIIESSQLDKSSVKTKNVIYIEPDEEVVEKMSKIDQFSGSLWTFDSTHPSAMI 108

  Fly   106 QMLTMTTQFLNLLTTSILDDAAVKDLLNSGEKFDLVIMEAVQ--TEALFGLIQHFGAETIGISSY 168
            ........|.......::....:.|.|.. |.|||.|.|.|.  ..|:|..::.....|: :|..
Worm   109 AKSNALVGFFGTQCKKVMRQQKILDQLRD-ENFDLAITEPVDGCAYAIFEYLKIRDHVTV-LSCV 171

  Fly   169 GTDTHIDELMGN-ISPLSYNPLLLSSRTEQMDFKDRVMNVFEASVMWLHKR--IVHLPSQRDLYA 230
            ..| |:.:::|. |:| ||.|...|...::|..|:|::|.    :.:.:.|  ..::..|....|
Worm   172 RFD-HVSDILGQPIAP-SYVPGTQSFFNDRMTMKERLLNF----IQFYYGRFTFANILDQEYEMA 230

  Fly   231 KYFPTARKSLDEVLDSFALMLLGQHFS-LSYPRPYLPNMIEVGGLHLQQKRKVQPLAKELSEFVE 294
            |.....::|..|||.. |..:...|.. |.:|.|....:|.:||..::...|...:.|:....:.
Worm   231 KDILGIQRSWREVLPE-ASFIFSNHIPVLDFPSPTFDKIIPIGGFTVKTNEKSLKIDKKWDAILN 294

  Fly   295 QSEKGVIYFSMGSNIKSKDLPPSTRKMLMQTFASVPQRV-LWKFEDD--QLPEKPDNVFISKWFP 356
            ..:|.|: .|.|||.||||:|...:|.|::.|:|:|... :||:||.  .:.:..||||||.|.|
Worm   295 IRKKNVL-ISFGSNAKSKDMPEEYKKTLLRVFSSMPDTTFIWKYEDPNVNIAKNLDNVFISSWLP 358

  Fly   357 QPDILAHPNVKLFITHGGLLSTIESIYFGKPILGLPIFYDQHLNVQRAKQVGYGLSADIWSVNAT 421
            |.::||...|.:|:|||||.|.:|....|||.:.:|||.||..|.|..|:.| |.:.    :..|
Worm   359 QNELLADSRVTVFVTHGGLASVMELALMGKPAIMIPIFADQGRNAQMLKRHG-GAAV----LQKT 418

  Fly   422 ELT------PLIQELLSNPSYAAAAQTKSKLFRDQKETALERAIWWTEYVLRHKGAKHLRCASRD 480
            :|:      ..:.::|:.|||...|:..:::..:|...|.|..:            ||:..|:|
Worm   419 DLSNFDLVRDTLNDVLTKPSYKLNAKKLAEMLNNQPTNAKEVLV------------KHVEFAAR- 470

  Fly   481 LDFIQFHGLDTWGL---LIAITFVSLLIVV--ILIKCLQRVFVSLIS-KIRKNRAEASK 533
              |.:...||.:|.   ::...|:.:|.::  :||.... :||.|:. .:.:||:...|
Worm   471 --FGKLPMLDNYGRHQNIVEYYFIDILTIILSVLISVFY-IFVRLLRFMLSRNRSTKDK 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35A1	NP_524314.2	egt	19..474	CDD:223071	125/447 (28%)
Ugt35A1	NP_524314.2	UDPGT	55..526	CDD:278624	139/505 (28%)
ugt-24	NP_500931.3	UDPGT	32..519	CDD:278624	139/505 (28%)
ugt-24	NP_500931.3	egt	<251..504	CDD:223071	83/273 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.810