DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35A1 and ugt-52

DIOPT Version :9

Sequence 1:	NP_524314.2	Gene:	Ugt35A1 / 41334	FlyBaseID:	FBgn0026315	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_499988.1	Gene:	ugt-52 / 176904	WormBaseID:	WBGene00018931	Length:	541	Species:	Caenorhabditis elegans

Alignment Length:	559	Identity:	122/559 - (21%)
Similarity:	228/559 - (40%)	Gaps:	81/559 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LIWLFAANADEGVQSSRILAVFPFPGRSQYIFAEQFMKELAHRGHNVTVI--------------- 66
            |::||  .....:|:..:|......|:|...|.:..::.|...||.|.:|
Worm    19 LVFLF--TLPRVIQTLHVLFYILLLGKSHIDFTDSLIESLVENGHTVDLIIARMNSHVKSNGTNM 81

  Fly    67 ----NTFGSDKNEPNFRVIGAKKIHEIMAAFGNADYTQTASQWQMLTMTTQFLNLLTTSILDDAA 127
                .|:|..:..|      ..|...::..|...:.|     |...|.....:..|....|.||.
Worm    82 VTRKYTYGFQEESP------WNKAPHLLNPFKGRERT-----WNEHTYYMDIVTDLCEIGLSDAG 135

  Fly   128 VKDLLNSGEKFDLVIMEAVQTEALFGLIQHFGAETI-GISSYGTDTHIDELMGNISPLSYNPLLL 191
            :...::| :|:|:.|....:...: .|::::...:| .:||    ..|.:.....:.:..:|.:.
Worm   136 LHAFISS-QKYDIGIATEYENCGV-ALMKYYKIPSIVSVSS----LPILDRQSLAAGMPNSPAVT 194

  Fly   192 SSRTEQMDFKDRVMNVFEASVMWLHKRIVHLP----SQRDLYAKY----FPTARKSLDEVLDSFA 248
            .:..|..|. ......|...:.|.|..::..|    .|.::..|:    |.|:     .:::|..
Worm   195 QAIFEAEDL-TTYWGKFRNFLNWAHITLIINPYCEKHQSEVIKKHLGENFDTS-----NLIESLD 253

  Fly   249 LMLLGQHFSLSYPRPYLPNMIEVGGLHLQQKRKVQPLAKELSEFVEQSE--KGVIYFSMGSNIKS 311
            |..:..:..:..||.....:..:||::|  |:....|.:|:.:.:.|..  .|::.|..|:.:.|
Worm   254 LAFVNSNELIETPRVSSHKIKYIGGINL--KKSKDRLDEEVEKVITQKPIGNGIVVFCFGTQVPS 316

  Fly   312 KDLPPSTRKMLMQTFASVPQ-RVLWKFE----DDQLPEKPDNVFISKWFPQPDILAHPNVKLFIT 371
            ...|...|:...|.|...|. ..:||:|    |:|:.....|:.:.||.||.|:|.....|.||:
Worm   317 SLFPIEVRRAFAQAFRHFPDFTFVWKYEMQDGDEQIFANTTNLRLLKWLPQTDLLNDARTKAFIS 381

  Fly   372 HGGLLSTIESIYFGKPILGLPIFYDQHLNVQRAKQVGYGLSADIWSVNATELTPLIQELLSNPSY 436
            |.||.|.:||.|.|.|||.:|:|.||..|......:|.....|...:....:...::.:|.:.||
Worm   382 HVGLNSYLESSYAGVPILAVPLFADQPHNAFSGMSIGTTYMLDKTRLTTPNIVKGLEAVLYDSSY 446

  Fly   437 AAAAQTKSKLFRDQKETALERAIWWTEYVLR----HKGAKHLRCASRDLDFIQFHGLDTWGLLIA 497
            ...|:..||:..::.....:..:.|.|:..|    |   ::|....:::...:::.||      .
Worm   447 TLNAKRISKMLHERPNPPKKIFVEWIEFASRNPLLH---RNLNLIGQNMSVFEYYCLD------I 502

  Fly   498 ITF-VSLLIVVILIKCLQRVFVSLISK-----IRKNRAE 530
            |:| :.||.:||.:..|...:||.:.:     ::|.:.|
Worm   503 ISFCILLLSIVISVFYLGTGWVSRMGRRVFGILKKRKVE 541

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35A1	NP_524314.2	egt	19..474	CDD:223071	107/493 (22%)
Ugt35A1	NP_524314.2	UDPGT	55..526	CDD:278624	112/515 (22%)
ugt-52	NP_499988.1	UDPGT	53..537	CDD:278624	112/517 (22%)
ugt-52	NP_499988.1	Glycosyltransferase_GTB_type	<231..517	CDD:299143	76/301 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.810