DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35A1 and ugt-28

DIOPT Version :9

Sequence 1:	NP_524314.2	Gene:	Ugt35A1 / 41334	FlyBaseID:	FBgn0026315	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_491437.1	Gene:	ugt-28 / 172086	WormBaseID:	WBGene00015693	Length:	537	Species:	Caenorhabditis elegans

Alignment Length:	551	Identity:	144/551 - (26%)
Similarity:	234/551 - (42%)	Gaps:	74/551 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 SSRILAVFPFPGRSQYIFAEQFMKELAHRGHNVTVINTFGSDKNEPNFRVIGAKKIHEIMAAFGN 95
            |..||...|....|...|..:....|..||||||.:           ..|:..:|..|.:.....
Worm    17 SLNILVYSPAFAASHSNFLGKLADTLTERGHNVTYL-----------MPVVDPEKRDECIGVKLT 70

  Fly    96 ADYTQTASQWQML------TMTTQFLNLLTTSILDDAAVKDL---LNSGEK-------------- 137
            .|........:|:      |...:.:.|...|.:|.:..:|:   .||..|
Worm    71 KDLVIVEPDEEMMSFKKGSTPNGEIMELFWKSEMDSSNSRDMFSFFNSDMKLACRNFHKRRDIFE 135

  Fly   138 ------FDLVIMEAVQTEALFGLIQHFGAETIGISSYGTDTHIDELMGNI-SPL--SYNPLLLSS 193
                  ||:.|:|.| |....|.::..|.|...::|  :.|..|.:|..| .||  ||.|...|.
Worm   136 QMKSRNFDVAILEPV-TICGLGFVKALGIEKTILAS--SSTFYDAVMDYIGEPLDYSYVPSGFSV 197

  Fly   194 RTEQMDFKDRVMN---VFEASVMWLHKRI-VHLPSQRDLYAKYFPTARKSLDEVLDSFALMLLGQ 254
            ..:.|...:|..|   |.|.::. ||... ..:.|.|:...:..|..|    |:|.|.::..:..
Worm   198 TGDVMTMAERYENWMVVKEINIA-LHDMFDGEMKSYREFLGEDLPNWR----ELLSSASIFFVNA 257

  Fly   255 HFSLSYPRPYLPNMIEVGGLHLQQK-RKVQPLAKELSEFVEQSEKGVIYFSMGSNIKSKDLPPST 318
            :..|.:||..|...:.:||:.:..| .|.|.|.|:..:.:|:..|.|: .|.||.:||..:|...
Worm   258 NPFLDFPRAVLQKTVPIGGISINLKWIKEQKLTKDWEDILEKRTKTVL-ISFGSMVKSAYMPKIW 321

  Fly   319 RKMLMQTFASVPQ-RVLWKFEDDQL--PEKPDNVFISKWFPQPDILAHPNVKLFITHGGLLSTIE 380
            |..|::...|:|. ..::|:|.|::  .:...|:..|||.||..:|..|.:..|:|||||.||:|
Worm   322 RNGLLEVIKSMPDVTFIFKYESDEVSFADGISNIHFSKWVPQTALLNDPRLSAFVTHGGLGSTME 386

  Fly   381 SIYFGKPILGLPIFYDQHLN---VQRAKQVGYGLSADIWSVNATELTPLIQELLSNPSYAAAAQT 442
            ..|.|||.:.:|:|.||..|   :.|...|.|.....:.:|..|.  ..:.::|.:.||...|:.
Worm   387 LAYSGKPGVVIPVFADQIRNARMIARHNGVIYLHKNSMENVKVTR--KALTDVLYDESYKKNAEK 449

  Fly   443 KSKLFRDQKETALERAIWWTEYVLRHKGAKHLRCASRDLDFIQFHGLDTWGLLIAITFVSL-LIV 506
            .:.:..:|..:.:|..|.:||:|..|....:.....|.|::.|....|.:. |.|:.::|: .|:
Worm   450 LTDILMNQPYSPMENVIKYTEFVGEHGPFPNTDPYGRHLNYFQKTFFDIYA-LFALFYISVGTII 513

  Fly   507 VILIKCLQRVFVSLISKIRKNRAEASKLKTQ 537
            .|.|:.:.:       |.||........||:
Worm   514 AISIRFIYQ-------KARKYFTLEKSKKTE 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35A1	NP_524314.2	egt	19..474	CDD:223071	129/485 (27%)
Ugt35A1	NP_524314.2	UDPGT	55..526	CDD:278624	134/514 (26%)
ugt-28	NP_491437.1	UDPGT	40..536	CDD:278624	136/525 (26%)
ugt-28	NP_491437.1	egt	<193..472	CDD:223071	82/286 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.810