DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt35A1 and ugt-26

DIOPT Version :9

Sequence 1:	NP_524314.2	Gene:	Ugt35A1 / 41334	FlyBaseID:	FBgn0026315	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_491435.2	Gene:	ugt-26 / 172085	WormBaseID:	WBGene00015695	Length:	529	Species:	Caenorhabditis elegans

Alignment Length:	531	Identity:	124/531 - (23%)
Similarity:	227/531 - (42%)	Gaps:	69/531 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 VQSSRILAVFPFPGRSQYIFAEQFMKELAHRGHNVTVINTFGSDKNEPNFRVIGAKKI------- 86
            |.|..||...|....|...|..:....|...|||||.:.....::......|...|.:
Worm    19 VSSLNILVHSPAYAASHTNFMARLADTLTEAGHNVTFLVPIALEERRDKLGVKLTKDVIIVEQDE 83

  Fly    87 ---HEIMAAFGNADY-----TQTASQWQMLTMTTQFLNLLTTSILDDAAVKDLLNSGEKFDLVIM 143
               .:::...|:.::     ..::|...|.:...:.:.|...:.:.:..|...|.| ..||:.|.
Worm    84 EMKSKLVPHSGSIEFLWIIEMDSSSIDAMFSWYNEIMILTCENFMRNKQVMSELKS-RHFDVAIA 147

  Fly   144 EAVQTEALFGLIQHFG-AETIGISSYGTDTHIDELMGNI-SPLSYN--PLLLSSRTEQMDFKDRV 204
            |.. |....||.:... .:||.:||.   .|.|.::.:| .|..::  |.|.|...|:|...::
Worm   148 EPF-TICGLGLFEELNIKKTILVSSC---AHYDFMLPHIGEPEDFSSVPTLSSKVGEEMSMTEK- 207

  Fly   205 MNVFEASVMWLHKRIVH---------LPSQRDLYAKYFPTARKSLDEVLDSFALMLLGQHFSLSY 260
                     |.:.|:|.         ..::..:|.:.|.:......|::.|.:|.....:..:.|
Worm   208 ---------WENYRLVAETKASLAKLFDAETRIYRESFGSDIPDWKELMSSASLYFTNSNPFIDY 263

  Fly   261 PRPYLPNMIEVGGLHLQ-QKRKVQPLAKELSEFVEQSEKGVIYFSMGSNIKSKDLPPSTRKMLMQ 324
            ||..:...|.:||:.:. |:.|.:.|.||..|.:.:.:|.:: .|.|||:.|..:|.:.:..:.:
Worm   264 PRASIQKTISIGGITVDFQQIKSEKLNKEWEEVLNKRQKSML-ISFGSNVPSDKMPAAWKAGIFE 327

  Fly   325 TFASVPQ-RVLWKFEDDQL--PEKPDNVFISKWFPQPDILAHPNVKLFITHGGLLSTIESIYFGK 386
            |..|:|. ..:||:|.|.:  .:...|:..|||.||..:|..|.:..|:|||||.||.|..|..|
Worm   328 TIKSMPNVTFIWKYESDDVSFADGISNIHFSKWVPQTALLNDPRLSAFLTHGGLGSTNELAYCAK 392

  Fly   387 PILGLPIFYDQHLNVQRAKQVGYGLSADIWSV---------NATELTPLIQELLSNPSYAAAAQT 442
            |.:.:||:.||..|.....:.|        ||         |...:...:.::|.|..|..:|:.
Worm   393 PAVMVPIYGDQTRNANMLARHG--------SVIVLHKKELANVQRVKKAVHDILYNKQYTESAER 449

  Fly   443 KSKLFRDQKETALERAIWWTEYVLRHKGAKHLRCASRDLDFIQFHGLDTWGL----LIAITFVSL 503
            .:::.::|.:|..|..:.:||:|.::.....:....|.|.:.|...||.:.|    ::::..|:.
Worm   450 IAEMIKNQPKTPKETVVRYTEFVAKYGPFPQMAPHGRKLTYFQKTFLDIYSLFALGVVSVLTVAF 514

  Fly   504 LIVVILIKCLQ 514
            |::..::.|.:
Worm   515 LVIRYVLSCFK 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35A1	NP_524314.2	egt	19..474	CDD:223071	115/485 (24%)
Ugt35A1	NP_524314.2	UDPGT	55..526	CDD:278624	117/505 (23%)
ugt-26	NP_491435.2	egt	4..481	CDD:223071	115/485 (24%)
ugt-26	NP_491435.2	UDPGT	34..525	CDD:278624	119/514 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14289
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.810