Protein Alignment Ugt35A1 and UGT3A2

DIOPT Version :10

• Sequence 1: NP_524314.2
• Gene: Ugt35A1 / 41334
• FlyBaseID: FBgn0026315
• Length: 537
• Species: Drosophila melanogaster
• Sequence 2: XP_011512290.1
• Gene: UGT3A2 / 167127
• HGNCID: 27266
• Length: 550
• Species: Homo sapiens
• Alignment Length: 551
• Identity: 146/551 - (26%)
• Similarity: 259/551 - (47%)
• Gaps: 89/551 - (16%)

  Fly    12 ILLIGLIWLFAANADEGV---QSSRILAVFPFPGRSQYIFAEQFMKELAHRGHNVTVIN------ 67
            :||:|.:.       .||   ::::||.:... |.|.|:..::..:.|...|||||::|
Human     7 LLLVGFLL-------PGVLLSEAAKILTISTV-GGSHYLLMDRVSQILQDHGHNVTMLNHKRGPF 63

  Fly    68 ------TFGSDKNEPNFRVIGAKKIHEIMAAFGNADYTQTASQWQMLTMTT-------------- 112
                  :..|....|  |::..:|    ...||..|:.:....:|:::...
Human    64 MPGLSDSPASASRYP--RILYLQK----YCQFGLKDFKKEEKSYQVISWLAPEDHQREFKKSFDF 122

  Fly   113 ----------QFLNLLTTSILDDAAV--------KDLLNS--GEKFDLVIMEAVQTEALFGLIQH 157
                      :|.|||  ::|:..|:        ||:::|  .|.||:||:|... ...|.:.:.
Human   123 FLEETLGGRGKFENLL--NVLEYLALQCSHFLNRKDIMDSLKNENFDMVIVETFD-YCPFLIAEK 184

  Fly   158 FGAETIGI--SSYGTDTHIDELMGNISPLSYNPLLLSSRTEQMDFKDRVMNVFEASVMWLH--KR 218
            .|...:.|  :|:|:..     .|...||||.|:..|..|:.|||..||.|.    :|:..  :|
Human   185 LGKPFVAILSTSFGSLE-----FGLPIPLSYVPVFRSLLTDHMDFWGRVKNF----LMFFSFCRR 240

  Fly   219 IVHLPSQRDLYAK--YFPTARKSLDEVLDSFALMLLGQHFSLSYPRPYLPNMIEVGGLHLQQKRK 281
            ..|:.|..|...|  :...:|..|..:|....|..:...|:..:.||.|||.:.||||   .::.
Human   241 QQHMQSTFDNTIKEHFTEGSRPVLSHLLLKAELWFINSDFAFDFARPLLPNTVYVGGL---MEKP 302

  Fly   282 VQPLAKELSEFVEQ-SEKGVIYFSMGSNIKSKDLPPSTRKMLMQTFASVPQRVLWKFEDDQLPEK 345
            ::|:.::|..|:.: .:.|.:..::||.:.:...|...::| ...||.:||.|:||.:....|:.
Human   303 IKPVPQDLENFIAKFGDSGFVLVTLGSMVNTCQNPEIFKEM-NNAFAHLPQGVIWKCQCSHWPKD 366

  Fly   346 ---PDNVFISKWFPQPDILAHPNVKLFITHGGLLSTIESIYFGKPILGLPIFYDQHLNVQRAKQV 407
               ..||.|..|.||.|:||||:::||:||||..|.:|:|..|.|::|:|:|.||..|:.|.:..
Human   367 VHLAANVKIVDWLPQSDLLAHPSIRLFVTHGGQNSIMEAIQHGVPMVGIPLFGDQPENMVRVEAK 431

  Fly   408 GYGLSADIWSVNATELTPLIQELLSNPSYAAAAQTKSKLFRDQKETALERAIWWTEYVLRHKGAK 472
            .:|:|..:..:.|..|...:::::.:..|.:||...|.:.|....:..:|.:.|.::||:..||.
Human   432 KFGVSIQLKKLKAETLALKMKQIMEDKRYKSAAVAASVILRSHPLSPTQRLVGWIDHVLQTGGAT 496

  Fly   473 HLRCASRDLDFIQFHGLDTWGLLIAITFVSL 503
            ||:.......:.:.:.||.:..|:.:|..:|
Human   497 HLKPYVFQQPWHEQYLLDVFVFLLGLTLGTL 527

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35A1	NP_524314.2	Glycosyltransferase_GTB-type	19..474	CDD:471961	136/513 (27%)
UGT3A2	XP_011512290.1	Glycosyltransferase_GTB-type	23..518	CDD:471961	138/517 (27%)