DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt35A1 and Ugt1a7c

DIOPT Version :9

Sequence 1:	NP_524314.2	Gene:	Ugt35A1 / 41334	FlyBaseID:	FBgn0026315	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_569091.2	Gene:	Ugt1a7c / 154516	RGDID:	620950	Length:	531	Species:	Rattus norvegicus

Alignment Length:	531	Identity:	162/531 - (30%)
Similarity:	252/531 - (47%)	Gaps:	73/531 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LLIGLIWLFAANADEGVQSSRILAVFPFPGRSQYIFAEQFMKELAHRGHNVTVINTFGS-DKNEP 76
            |.:||..|.|:    |...:..|.|.|..| |.:...:..:::|..:||.|.|:....| ...:|
  Rat    10 LPLGLCLLLAS----GFGHAGKLLVVPMDG-SHWFTMQMVVEKLLPKGHEVVVVVPEVSWQLGKP 69

  Fly    77 -NFRVIGAKKIHEIMAAFGNADYTQ----------TASQWQ---------MLTMTTQ-FLNLLTT 120
             ||.|    |.:.:       .:||          ..|||:         :||...| |..||.:
  Rat    70 LNFTV----KTYSV-------SHTQEDLNREFKFFIDSQWKTQQEGGVLPLLTSPAQGFFELLFS 123

  Fly   121 ---SILDDAAVKDLLNSGEKFDLVIMEAVQTEALFGLIQHFGAETIGISSYGTDTH-IDELMGNI 181
               |:..|..:.:.|.. ..||.|.::......| .:.::|...:: :.|.|...| ::|.....
  Rat   124 HCRSLFKDKKLVEYLKQ-SSFDAVFLDPFDVCGL-TVAKYFSLPSV-VFSRGIFCHYLEEGSQCP 185

  Fly   182 SPLSYNPLLLSSRTEQMDFKDRVMNVFEASVMWLHKRIVHLPSQRDLYAKYFPTARKSLDEVL-- 244
            ||.||.|..:...|:.|.||:||.|:.  |.|..|   ...||       :|.||.....|||
  Rat   186 SPPSYVPRGILKLTDTMTFKERVWNLL--SYMGEH---AFCPS-------FFKTATDIASEVLQT 238

  Fly   245 -----DSF---ALMLLGQHFSLSYPRPYLPNMIEVGGLHLQQKRKVQPLAKELSEFVEQS-EKGV 300
                 |.|   ::.||...|:|..|||.:||:|.:||::..|::   ||:||...:|..| |.|:
  Rat   239 PVTMTDLFSPVSVWLLRTDFTLELPRPVMPNVIHIGGINCHQRK---PLSKEFEAYVNASGEHGI 300

  Fly   301 IYFSMGSNIKSKDLPPSTRKMLMQTFASVPQRVLWKFEDDQLPEKPDNVFISKWFPQPDILAHPN 365
            :.||:||.:  .::|......:.:....:||.|||::...:......|..:.||.||.|:|.||.
  Rat   301 VVFSLGSMV--SEIPEKKAMEIAEALGRIPQTVLWRYTGTRPSNLAKNTILVKWLPQNDLLGHPK 363

  Fly   366 VKLFITHGGLLSTIESIYFGKPILGLPIFYDQHLNVQRAKQVGYGLSADIWSVNATELTPLIQEL 430
            .:.||||.|.....|.|..|.|::.:|:|.||..|.:|.:..|.|::.::..:.|.:|...::.:
  Rat   364 ARAFITHSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTV 428

  Fly   431 LSNPSYAAAAQTKSKLFRDQKETALERAIWWTEYVLRHKGAKHLRCASRDLDFIQFHGLDTWGLL 495
            ::|.||.......|.|.:|:....|:.|::|.|||:|||||.|||.|:.||.:.|:|.||..|.|
  Rat   429 INNKSYKENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFL 493

  Fly   496 IAITFVSLLIV 506
            :||....:.||
  Rat   494 LAIVLTVVFIV 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35A1	NP_524314.2	egt	19..474	CDD:223071	143/491 (29%)
Ugt35A1	NP_524314.2	UDPGT	55..526	CDD:278624	151/489 (31%)
Ugt1a7c	NP_569091.2	UDPGT	26..522	CDD:278624	156/511 (31%)
Ugt1a7c	NP_569091.2	egt	<264..505	CDD:223071	87/246 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	256	1.000	Domainoid score	I1959
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2882
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm9018
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.860