Protein Alignment Ugt35A1 and UGT3A1

DIOPT Version :10

• Sequence 1: NP_524314.2
• Gene: Ugt35A1 / 41334
• FlyBaseID: FBgn0026315
• Length: 537
• Species: Drosophila melanogaster
• Sequence 2: XP_047272663.1
• Gene: UGT3A1 / 133688
• HGNCID: 26625
• Length: 526
• Species: Homo sapiens
• Alignment Length: 511
• Identity: 139/511 - (27%)
• Similarity: 240/511 - (46%)
• Gaps: 71/511 - (13%)

  Fly    44 SQYIFAEQFMKELAHRGHNVTVINTFGS------DKNEPNFRVIG--AKKIHE--IMAAFGNADY 98
            |.|:..::..:.|...|||||:::..|.      .:.|.:::||.  :.:.|:  |...|.:  |
Human    37 SHYLLLDRVSQILQEHGHNVTMLHQSGKFLIPDIKEEEKSYQVIRWFSPEDHQKRIKKHFDS--Y 99

  Fly    99 TQTASQWQ---------MLTMTTQFLNLLTTSILDDAAVKDLLNS--GEKFDLVIMEAVQTEALF 152
            .:||...:         |....||...||:.        ||:::|  .|.:|||.:||....:..
Human   100 IETALDGRKESEALVKLMEIFGTQCSYLLSR--------KDIMDSLKNENYDLVFVEAFDFCSFL 156

  Fly   153 ---GLIQHFGA---ETIGISSYGTDTHIDELMGNISPLSYNPLLLSSRTEQMDFKDRVMNVFEAS 211
               .|::.|.|   .|.|...:|..          |||||.|:..|..|:.|||..||.|..
Human   157 IAEKLVKPFVAILPTTFGSLDFGLP----------SPLSYVPVFPSLLTDHMDFWGRVKNFL--- 208

  Fly   212 VMWLHKRIVHLPSQRDLYA-------KYFPT-ARKSLDEVLDSFALMLLGQHFSLSYPRPYLPNM 268
            :.:...|     ||.|:.:       ::||. :|..|..:|....|..:...|:..:.||.|||.
Human   209 MFFSFSR-----SQWDMQSTFDNTIKEHFPEGSRPVLSHLLLKAELWFVNSDFAFDFARPLLPNT 268

  Fly   269 IEVGGLHLQQKRKVQPLAKELSEFVEQ-SEKGVIYFSMGSNIKSKDLPPSTRKMLMQTFASVPQR 332
            :.:|||   .::.::|:.::|..|:.. .:.|.:..:.||.:.:.......:|| ...||.:||.
Human   269 VYIGGL---MEKPIKPVPQDLDNFIANFGDAGFVLVAFGSMLNTHQSQEVLKKM-HNAFAHLPQG 329

  Fly   333 VLWKFEDDQLPEK---PDNVFISKWFPQPDILAHPNVKLFITHGGLLSTIESIYFGKPILGLPIF 394
            |:|..:....|..   ..||.|..|.||.|:||||:::||:||||..|.:|:|..|.|::|||:.
Human   330 VIWTCQSSHWPRDVHLATNVKIVDWLPQSDLLAHPSIRLFVTHGGQNSVMEAIRHGVPMVGLPVN 394

  Fly   395 YDQHLNVQRAKQVGYGLSADIWSVNATELTPLIQELLSNPSYAAAAQTKSKLFRDQKETALERAI 459
            .|||.|:.|.....||:|..:..|.|..||..:::::.:..|.:|....|.:...|..:..:|.:
Human   395 GDQHGNMVRVVAKNYGVSIRLNQVTADTLTLTMKQVIEDKRYKSAVVAASVILHSQPLSPAQRLV 459

  Fly   460 WWTEYVLRHKGAKHLRCASRDLDFIQFHGLDTWGLLIAITFVSLLIVVILIKCLQR 515
            .|.:::|:..||.||:..:....:.:.:.:|.:..|:.:|..::.:...|:..:.|
Human   460 GWIDHILQTGGATHLKPYAFQQPWHEQYLIDVFVFLLGLTLGTMWLCGKLLGVVAR 515

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35A1	NP_524314.2	Glycosyltransferase_GTB-type	19..474	CDD:471961	132/468 (28%)
UGT3A1	XP_047272663.1	Glycosyltransferase_GTB-type	36..526	CDD:471961	139/511 (27%)