DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35A1 and Ugt1a6

DIOPT Version :9

Sequence 1:	NP_524314.2	Gene:	Ugt35A1 / 41334	FlyBaseID:	FBgn0026315	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_001034780.1	Gene:	Ugt1a6 / 113992	RGDID:	620949	Length:	530	Species:	Rattus norvegicus

Alignment Length:	506	Identity:	150/506 - (29%)
Similarity:	241/506 - (47%)	Gaps:	64/506 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 LAVFPFPGRSQYIFAEQFMKELAHRGHNVTV----IN-TFGSDK--NEPNFRV-IGAKKIHEIMA 91
            |.|.|..| |.::..::.::.|:.|||::.|    :| ..|..|  ...:|.| ...:::.....
  Rat    28 LLVVPQDG-SHWLSMKEIVEHLSERGHDIVVLVPEVNLLLGESKYYRRKSFPVPYNLEELRTRYR 91

  Fly    92 AFGNADYTQTASQWQMLTMTTQFLNLLT--------TSILDDAAVKDLLNSGEKFDLVIMEAVQT 148
            :|||..:  .||...|..:.....|::.        .|:|.|:|....|...           |.
  Rat    92 SFGNNHF--AASSPLMAPLREYRNNMIVIDMCFFSCQSLLKDSATLSFLREN-----------QF 143

  Fly   149 EALF-------GLIQHFGAETIGISSY----GTDTHIDELMG-NISPLSYNPLLLSSRTEQMDFK 201
            :|||       |:|.   ||.:.:.|.    |....::.::| :.||:||.|...:..::.|.|.
  Rat   144 DALFTDPAMPCGVIL---AEYLKLPSVYLFRGFPCSLEHMLGQSPSPVSYVPRFYTKFSDHMTFP 205

  Fly   202 DRVMNVFEASVMWLHKRIVHLPSQRDLYAKYFPTARKSLDE-----VLDSFALMLLGQHFSLSYP 261
            .|:.| |.|::  |...:.|.     ||:||...|...|..     .|...:|.||...|...||
  Rat   206 QRLAN-FIANI--LENYLYHC-----LYSKYEILASDLLKRDVSLPALHQNSLWLLRYDFVFEYP 262

  Fly   262 RPYLPNMIEVGGLHLQQKRKVQPLAKELSEFVEQS-EKGVIYFSMGSNIKSKDLPPSTRKMLMQT 325
            ||.:||||.:||.:.::|..   |::|...:|..| |.|::.||:||.:  .::|......:.:.
  Rat   263 RPVMPNMIFIGGTNCKKKGN---LSQEFEAYVNASGEHGIVVFSLGSMV--SEIPEKKAMEIAEA 322

  Fly   326 FASVPQRVLWKFEDDQLPEKPDNVFISKWFPQPDILAHPNVKLFITHGGLLSTIESIYFGKPILG 390
            ...:||.|||::...:......|..:.||.||.|:|.||..:.||||.|.....|.|..|.|::.
  Rat   323 LGRIPQTVLWRYTGTRPSNLAKNTILVKWLPQNDLLGHPKARAFITHSGSHGIYEGICNGVPMVM 387

  Fly   391 LPIFYDQHLNVQRAKQVGYGLSADIWSVNATELTPLIQELLSNPSYAAAAQTKSKLFRDQKETAL 455
            :|:|.||..|.:|.:..|.|::.::..:.|.:|...::.:::|.||.......|.|.:|:....|
  Rat   388 MPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVINNKSYKENIMRLSSLHKDRPIEPL 452

  Fly   456 ERAIWWTEYVLRHKGAKHLRCASRDLDFIQFHGLDTWGLLIAITFVSLLIV 506
            :.|::|.|||:|||||.|||.|:.||.:.|:|.||..|.|:||....:.||
  Rat   453 DLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAIVLTVVFIV 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35A1	NP_524314.2	egt	19..474	CDD:223071	134/472 (28%)
Ugt35A1	NP_524314.2	UDPGT	55..526	CDD:278624	145/486 (30%)
Ugt1a6	NP_001034780.1	egt	14..504	CDD:223071	150/506 (30%)
Ugt1a6	NP_001034780.1	UDPGT	26..521	CDD:278624	150/506 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	256	1.000	Domainoid score	I1959
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2882
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm9018
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.860