DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35A1 and UGT2A1

DIOPT Version :9

Sequence 1:	NP_524314.2	Gene:	Ugt35A1 / 41334	FlyBaseID:	FBgn0026315	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_001376494.1	Gene:	UGT2A1 / 10941	HGNCID:	12542	Length:	737	Species:	Homo sapiens

Alignment Length:	528	Identity:	159/528 - (30%)
Similarity:	254/528 - (48%)	Gaps:	77/528 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 SQYIFAEQFMKELAHRGHNVTVINT-----FGSDKNEP-NFRVI--GAKKI-------HEIMAAF 93
            |.::..:..::||..|.|||||:.:     ..|:.:.| ||.||  ..||.       |.||...
Human   241 SHWLNIKIILEELIQRNHNVTVLASSATLFINSNPDSPVNFEVIPVSYKKSNIDSLIEHMIMLWI 305

  Fly    94 GNADYTQT-ASQW-------QMLTMTTQFLNLLTTSILDDAAVKDLLNSGEKFDLVIMEAVQTEA 150
               |:..| .:.|       ::|....|....|...:|.:..:...|..| .||:::.:.|.
Human   306 ---DHRPTPLTIWAFYKELGKLLDTFFQINIQLCDGVLKNPKLMARLQKG-GFDVLVADPVT--- 363

  Fly   151 LFGLIQHFGAETIGIS-----SYGTDTHIDELMGNI-SPLSYNPLLLSSRTEQMDFKDRVMNVFE 209
               :.....|..:||.     .:...:.::...|.| :|:||.|..||..|:||.|.:|:.|...
Human   364 ---ICGDLVALKLGIPFMYTLRFSPASTVERHCGKIPAPVSYVPAALSELTDQMTFGERIKNTIS 425

  Fly   210 ASVM----------WLHKRIVHLPSQRDLYAKYF--PTARKSLDEVLDSFALMLLGQHFSLSYPR 262
            .|:.          |           ...|:|..  ||   :|.|.:....:.|:..::...:||
Human   426 YSLQDYIFQSYWGEW-----------NSYYSKILGRPT---TLCETMGKAEIWLIRTYWDFEFPR 476

  Fly   263 PYLPNMIEVGGLHLQQKRKVQPLAKELSEFVEQSEK-GVIYFSMGSNIKSKDLPPSTRKMLMQTF 326
            |||||...|||||.   :..:||.||:.||::.|.| ||:.||:||.:  |:|......::....
Human   477 PYLPNFEFVGGLHC---KPAKPLPKEMEEFIQSSGKNGVVVFSLGSMV--KNLTEEKANLIASAL 536

  Fly   327 ASVPQRVLWKFEDDQLPEKPDNVFISKWFPQPDILAHPNVKLFITHGGLLSTIESIYFGKPILGL 391
            |.:||:|||:::..:.....:|..:..|.||.|:|.||..|.||||||.....|:||.|.|::|:
Human   537 AQIPQKVLWRYKGKKPATLGNNTQLFDWIPQNDLLGHPKTKAFITHGGTNGIYEAIYHGVPMVGV 601

  Fly   392 PIFYDQHLNVQRAKQVGYGLSADIWSVNATELTPLIQELLSNPSYAAAAQTKSKLFRDQKETALE 456
            |:|.||..|:...|..|..:..::.::.:.:|...::.:::.|||...|...|::..||....|:
Human   602 PMFADQPDNIAHMKAKGAAVEVNLNTMTSVDLLSALRTVINEPSYKENAMRLSRIHHDQPVKPLD 666

  Fly   457 RAIWWTEYVLRHKGAKHLRCASRDLDFIQFHGLDTWG-LLIAITFVSLLIVVILIKCLQRVFVSL 520
            ||::|.|:|:|||||||||.|:.||.:.|:|.||..| ||:.:|....|::...:...|:
Human   667 RAVFWIEFVMRHKGAKHLRVAAHDLTWFQYHSLDVIGFLLVCVTTAIFLVIQCCLFSCQK----- 726

  Fly   521 ISKIRKNR 528
            ..||.|.:
Human   727 FGKIGKKK 734

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35A1	NP_524314.2	egt	19..474	CDD:223071	140/471 (30%)
Ugt35A1	NP_524314.2	UDPGT	55..526	CDD:278624	157/513 (31%)
UGT2A1	NP_001376494.1	UDPGT	237..725	CDD:278624	155/512 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150200
Domainoid	1	1.000	260	1.000	Domainoid score	I1978
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	267	1.000	Inparanoid score	I3041
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm8543
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	10.690