Protein Alignment Ugt35A1 and UGT2B11

DIOPT Version :10

• Sequence 1: NP_524314.2
• Gene: Ugt35A1 / 41334
• FlyBaseID: FBgn0026315
• Length: 537
• Species: Drosophila melanogaster
• Sequence 2: NP_001064.1
• Gene: UGT2B11 / 10720
• HGNCID: 12545
• Length: 529
• Species: Homo sapiens
• Alignment Length: 516
• Identity: 159/516 - (30%)
• Similarity: 248/516 - (48%)
• Gaps: 82/516 - (15%)

  Fly    44 SQYIFAEQFMKELAHRGHNVTVINTFGSDKNEPN------FRVIGAKKIHEIMAAFGNADYTQTA 102
            |.::..:..:|||..|||.|||:.:..|...:||      |.|.....   ....|.|....|..
Human    34 SHWMNMKTILKELVQRGHEVTVLASSASILFDPNDASTLKFEVYPTSL---TKTEFENIIMQQVK 95

  Fly   103 --------------SQ-----WQMLTMTTQFLNLLTTSILDDAAVKDLLNSGEKFDLVIMEAVQT 148
                          ||     |::..:   |.|.....:.:...:|.|..|  :||:|..:||..
Human    96 RWSDIRKDSFWLYFSQEQEILWELYDI---FRNFCKDVVSNKKVMKKLQES--RFDIVFADAVFP 155

  Fly   149 --EALFGLIQ-HFGAETIGISSYGTDTHIDELMGNISPLSYNPLLLSSRTEQMDFKDRVMNV--- 207
              |.|..|:. .|.........|..:.|..   |.|.|.||.|:::|..::||.|.:||.|:
Human   156 CGELLAALLNIRFVYSLRFTPGYTIERHSG---GLIFPPSYIPIVMSKLSDQMTFMERVKNMIYV 217

  Fly   208 ------FEASVM--W--LHKRIVHLPSQRDLYAKYFPTARKSLDEVLDSFALMLLGQHFSLSYPR 262
                  |:.|.|  |  .:..::..|:              :|.|.:....:.|:...:|..:|.
Human   218 LYFDFWFQMSDMKKWDQFYSEVLGRPT--------------TLFETMGKADIWLMRNSWSFQFPH 268

  Fly   263 PYLPNMIEVGGLHLQQKRKVQPLAKELSEFVEQS-EKGVIYFSMGSNIKSKDLPPSTRKMLMQTF 326
            |:|||:..|||.|.   :..:||.||:.|||:.| |.||:.||:||.|  .::......::....
Human   269 PFLPNVDFVGGFHC---KPAKPLPKEMEEFVQSSGENGVVVFSLGSVI--SNMTAERANVIATAL 328

  Fly   327 ASVPQRVLWKFEDDQLPEKPD----NVFISKWFPQPDILAHPNVKLFITHGGLLSTIESIYFGKP 387
            |.:||:|||:|:.:    |||    |..:.||.||.|:|.||..:.||||||.....|:||.|.|
Human   329 AKIPQKVLWRFDGN----KPDALGLNTRLYKWIPQNDLLGHPKTRAFITHGGANGIYEAIYHGIP 389

  Fly   388 ILGLPIFYDQHLNVQRAKQVGYGLSADIWSVNATELTPLIQELLSNPSYAAAAQTKSKLFRDQKE 452
            ::|:|:|:||..|:...|..|..:..|..::::|:|...::.::::|.|.......|::..||..
Human   390 MVGIPLFFDQPDNIAHMKAKGAAVRLDFNTMSSTDLLNALKTVINDPLYKENIMKLSRIQHDQPV 454

  Fly   453 TALERAIWWTEYVLRHKGAKHLRCASRDLDFIQFHGLDTWGLLIAITFVSLLIVVILIKCL 513
            ..|:||::|.|:|:.||||||||.|:.||.:.|:|.||..|.|:|.  |:.:|.:|...||
Human   455 KPLDRAVFWIEFVMPHKGAKHLRVAAHDLTWFQYHSLDVIGFLLAC--VATVIFIITKFCL 513

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35A1	NP_524314.2	Glycosyltransferase_GTB-type	19..474	CDD:471961	141/475 (30%)
UGT2B11	NP_001064.1	UDPGT	24..525	CDD:278624	159/516 (31%)