DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35A1 and Ugt2b34

DIOPT Version :9

Sequence 1:	NP_524314.2	Gene:	Ugt35A1 / 41334	FlyBaseID:	FBgn0026315	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_705826.1	Gene:	Ugt2b34 / 100727	MGIID:	2140962	Length:	532	Species:	Mus musculus

Alignment Length:	574	Identity:	162/574 - (28%)
Similarity:	272/574 - (47%)	Gaps:	107/574 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 ILLIGLIWLFAANADEGVQSSRILAVFPFPGRSQYIFAEQFMKELAHRGHNVTVI---------- 66
            :||:.|...|.:..     ..::| |:|.. .|.::..:..:.||..:||.|.|:
Mouse    11 LLLLQLSGFFGSGT-----GGKVL-VWPME-FSHWLNLKTILDELLKKGHEVMVLRPSASLSYEV 68

  Fly    67 -NT-----------FGSDKNEPNFRVIGAKKIHEIMAAFGNADYTQTASQW-------QMLTMTT 112
             ||           :...:.|..|.....|.|:|:          ...|.|       :|:.:.:
Mouse    69 DNTSAIEFETYPTSYSLSELEEIFWESLKKYIYEL----------PKQSFWGYFLMLQEMVWVDS 123

  Fly   113 QFLNLLTTSILDDAAVKDLLNSGEK--FDLV-----------IMEAVQTEALFGLIQHFGAETIG 164
            ::...|...::.:   |:|:...:|  ||::           :.|.::...::.| :.|...|
Mouse   124 KYFESLCKDVVFN---KELMTKLQKSRFDVILADPFIPCGDLLAEVLKIPLVYSL-RFFPGST-- 182

  Fly   165 ISSYGTDTHIDELMGNIS-PLSYNPLLLSSRTEQMDFKDRVMNV-----FEASVMWLHKRIVHLP 223
                     .::..|.:. |.||.|:::|..:::|.|.:||.||     |:   .|.  :..:..
Mouse   183 ---------YEKYSGGLPLPPSYVPVVMSELSDRMTFMERVRNVIYMLCFD---FWF--QTFNEK 233

  Fly   224 SQRDLYAKYF--PTARKSLDEVLDSFALMLLGQHFSLSYPRPYLPNMIEVGGLHLQQKRKVQPLA 286
            :...||.:..  ||   :|.|.:....:.|:..::.|.:|.|.|||...:||||.   |..:||.
Mouse   234 NWNQLYTEVLGRPT---TLSETMAKADIWLIRTYWDLEFPHPVLPNFDFIGGLHC---RPAKPLP 292

  Fly   287 KELSEFVEQS-EKGVIYFSMGSNIKSKDLPPSTRKMLMQTFASVPQRVLWKFEDDQLPEKPD--- 347
            ||:.:||:.| |.||:.||:||.:.|  :......::....|.:||:|||:||.    :||:
Mouse   293 KEIEDFVQSSGEHGVVVFSLGSMVGS--ITEERANVIAAGLAQIPQKVLWRFEG----KKPETLG 351

  Fly   348 -NVFISKWFPQPDILAHPNVKLFITHGGLLSTIESIYFGKPILGLPIFYDQHLNVQRAKQVGYGL 411
             |..:.||.||.|:|.|...:.||||||.....|:||.|.|::|:|:|.||:.|:...|..|..:
Mouse   352 SNTRLYKWIPQNDLLGHSKTRAFITHGGTNGIYEAIYHGIPVVGIPLFGDQYDNIVHLKAKGAAV 416

  Fly   412 SADIWSVNATELTPLIQELLSNPSYAAAAQTKSKLFRDQKETALERAIWWTEYVLRHKGAKHLRC 476
            ..|..::::|:|...::.:.::|||...|...|::..||....|:||::|.|:|:|||||||||.
Mouse   417 RLDFLTMSSTDLHTALKTVTNDPSYKENAMRLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRV 481

  Fly   477 ASRDLDFIQFHGLDTWGLLIAITFVSLLIVVILIKCLQRVFVSLISKIRKNRAE 530
            |:.||.::|:|.||..|.|:|..   |.::.||.||.......|....||.:.|
Mouse   482 AAHDLSWVQYHSLDVLGFLLACV---LTVMFILKKCCLFCCQKLTKAGRKKKGE 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35A1	NP_524314.2	egt	19..474	CDD:223071	137/509 (27%)
Ugt35A1	NP_524314.2	UDPGT	55..526	CDD:278624	151/525 (29%)
Ugt2b34	NP_705826.1	UDPGT	27..529	CDD:278624	156/548 (28%)
Ugt2b34	NP_705826.1	egt	<272..510	CDD:223071	97/249 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840428
Domainoid	1	1.000	259	1.000	Domainoid score	I1975
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2975
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm42461
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.690