DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35A1 and ugt2b3

DIOPT Version :9

Sequence 1:	NP_524314.2	Gene:	Ugt35A1 / 41334	FlyBaseID:	FBgn0026315	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_001170812.2	Gene:	ugt2b3 / 100384898	ZFINID:	ZDB-GENE-100402-2	Length:	527	Species:	Danio rerio

Alignment Length:	574	Identity:	167/574 - (29%)
Similarity:	272/574 - (47%)	Gaps:	102/574 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LGILLIGLIWLFAANADEGVQSSRILAVFPFPGRSQYIFAEQFMKELAHRGHNVTVINTFG---- 70
            |.:..:.|:.:|:|.     |...|| |:...| |.:|..:..:..|..|||||||:...|
Zfish     3 LVVCFLSLLTVFSAG-----QCGNIL-VWHTEG-SHWINLKIVLDTLLDRGHNVTVLMPDGALFM 60

  Fly    71 ----SDK-NEPNFRV-IGAKKIHEIMAAFGNADYTQTASQWQMLTMTTQFLNL----------LT 119
                ||: :..||.| ..|:.:.:.:....:....: ..|..:|.:..:|.:|          ..
Zfish    61 KAKESDRFSYQNFSVSTSAQDMQDFLDELLHFSVFE-MEQLNLLQIQMKFFDLGSRHQDMGLSYC 124

  Fly   120 TSILDDAAVKDLLNSGEKFDL-----------VIMEAVQTEALFGL---IQHFGAETIGISSYGT 170
            ..||....:.|.|.:| |||:           ::.|.:....:|.|   |.|
Zfish   125 DGILKSPELMDKLKTG-KFDVLLSDPMYPCSDIVAEVLNVPLVFTLRFSIAH------------- 175

  Fly   171 DTHIDELMGNI-SPLSYNPLLLSSRTEQMDFKDRVMN-VFEAS------VMWLHKRIVHLPSQRD 227
              .::.:.|.| :|.||.|..:|..|::|.|.:|:.| :|..|      :.|  |:.      .:
Zfish   176 --TMERICGQIPAPPSYVPGAMSKLTDKMSFTERIFNTLFYLSMDTFSIIAW--KKF------DN 230

  Fly   228 LYAKYF--PTARKSLDEVLDSFALMLLGQHFSLSYPRPYLPNMIEVGGLHLQQKRKVQPLAKELS 290
            .|.:||  ||   |..|::....:.|:..::...:|||::||...:||||.   ...:||.|::.
Zfish   231 YYTEYFGRPT---SYCEMMGRADIWLIRTYWDFEFPRPFVPNFKYIGGLHC---TPAKPLPKDME 289

  Fly   291 EFVEQS-EKGVIYFSMGSNIKSKDLPPSTRKMLMQTFASVPQRVLWKFEDDQLPEKPD----NVF 350
            |||:.| :.|::.|::||.|..  :|......:....|.:||:|||::..    ||||    |..
Zfish   290 EFVQSSGDDGIVVFTLGSMIDK--VPKEMSNRIASALAQIPQKVLWRYGG----EKPDTLGENTR 348

  Fly   351 ISKWFPQPDILAHPNVKLFITHGGLLSTIESIYFGKPILGLPIFYDQHLNVQRAKQVGYGLSAD- 414
            |.||.||.|:|.||..:.||||||.....|:||.|.|::|:|:|.||..|:......|..:..|
Zfish   349 IYKWMPQNDLLGHPKTRAFITHGGTNGIYEAIYHGVPMVGIPLFGDQPDNMVHMTTRGAAVVVDS 413

  Fly   415 IWSVNATELTPLIQELLSNPSYAAAAQTKSKLFRDQKETALERAIWWTEYVLRHKGAKHLRCASR 479
            |.|:...||...:..::::|||...|...|::..|:....|:.:::|.|:|:|:|||||||..:.
Zfish   414 IKSMQPQELVDKLNTVINDPSYKENAMRLSRIHHDRPMKPLDESVFWIEFVMRNKGAKHLRVEAH 478

  Fly   480 DLDFIQFHGLDTWGLLIAITFVSLLIVVILIKCLQRVFV---SLISKIRKNRAE 530
            :|.:.|:|.||.:..|   |.|..|::.|..| :.:.|:   ...|| ||::.|
Zfish   479 NLTWYQYHCLDVFAFL---TTVLTLVLYICFK-MAKFFIMRCCFRSK-RKSKKE 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35A1	NP_524314.2	egt	19..474	CDD:223071	145/504 (29%)
Ugt35A1	NP_524314.2	UDPGT	55..526	CDD:278624	153/523 (29%)
ugt2b3	NP_001170812.2	UDPGT	20..523	CDD:278624	159/546 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584887
Domainoid	1	1.000	252	1.000	Domainoid score	I2043
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55988
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.690