DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35A1 and ugt1a6

DIOPT Version :9

Sequence 1:	NP_524314.2	Gene:	Ugt35A1 / 41334	FlyBaseID:	FBgn0026315	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_001107366.1	Gene:	ugt1a6 / 100135191	XenbaseID:	XB-GENE-5793241	Length:	531	Species:	Xenopus tropicalis

Alignment Length:	524	Identity:	148/524 - (28%)
Similarity:	245/524 - (46%)	Gaps:	75/524 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 ADEGVQSSRILAVFPFPGRSQYIFAEQFMKELAHRGHNVTV----INTFGSDKNEPNFRVIGAKK 85
            ||.|    |:|.| |..| |.::.....:..||.|||.:.|    :|....|.:....:...:..
Frog    25 ADGG----RLLVV-PQDG-SHWLSMRVLVDRLAQRGHYIVVAIPEVNMLFKDLDNYKVKTFSSPY 83

  Fly    86 IHEIM---------AAFGNADYTQTASQW-QMLTMTTQFL-----NLLTTSILDDAAVKDLLNSG 135
            ..:::         ..|.:...|:..:.| :.::..||::     :.|..|.|    :::|  ..
Frog    84 SKDVLENRMRRMNQEIFVDRILTEKITFWYESMSNATQWVVSACQHFLQNSTL----IREL--EK 142

  Fly   136 EKFDLVIMEAVQTEALF--GLIQHFGAETIGISSY----GTDTHIDELMGNI-SPLSYNPLLLSS 193
            |.||     |:.|:::|  |.|.   ||.:.|.|.    ||...:|::.... ||.||.|.:.:.
Frog   143 EHFD-----AMLTDSVFPCGEIV---AEHLSIPSVSFMRGTIFGMDQIASQTPSPPSYVPRMFTV 199

  Fly   194 RTEQMDFKDRVMNVFEASVMWLHKRIVHLPSQRDLYAKYFPTARKSLD---------EVLDSFAL 249
            .|:.|.|..||.|.           ::|.......:..|:|.|:.:.|         .:....::
Frog   200 YTDNMSFSQRVKNF-----------LIHSLEHIVCHIFYYPYAQMASDFLKKEVTAMSLFSRTSI 253

  Fly   250 MLLGQHFSLSYPRPYLPNMIEVGGLHLQQKRKVQPLAKELSEFVEQS-EKGVIYFSMGSNIKSKD 313
            .|:...|...:|||.:||:|.:||::. .|:|..|  :|..:.|:.| |.|.:.||.||.:  .:
Frog   254 WLMRYDFVFEFPRPIMPNVILIGGINC-AKQKALP--QEFEKLVKSSGEHGFVVFSFGSMV--SE 313

  Fly   314 LPPSTRKMLMQTFASVPQRVLWKFEDDQLPEKPDNVFISKWFPQPDILAHPNVKLFITHGGLLST 378
            :|.:....:.:....:||:|.|::.....|...||..:.||.||.|:||||..:.||||.|....
Frog   314 IPMNIAMDIAEALRYIPQKVFWRYTGKAPPNLGDNTHLVKWLPQNDLLAHPKARAFITHAGSHGV 378

  Fly   379 IESIYFGKPILGLPIFYDQHLNVQRAKQVGYGLSADIWSVNATELTPLIQELLSNPSYAAAAQTK 443
            .|.|....|::.||:..||..|.:|.:..|.||..::.::...:|:..:..::.||||....|..
Frog   379 YEGICNAVPMVMLPLIGDQMDNAKRIESRGAGLILNVQNLIPDDLSNAVMAVIDNPSYKENIQRL 443

  Fly   444 SKLFRDQKETALERAIWWTEYVLRHKGAKHLRCASRDLDFIQFHGLDTWGLLIAITFVSLLIVVI 508
            |.|.||:....|:.|:.|.|:|::||||.|||.|:.||::||:..||....|:|:...:|.   |
Frog   444 SSLHRDRPVQPLDLAVHWVEFVMKHKGAPHLRPAAHDLNWIQYQSLDVMAFLLAVLLTTLF---I 505

  Fly   509 LIKC 512
            .:||
Frog   506 SLKC 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35A1	NP_524314.2	egt	19..474	CDD:223071	132/484 (27%)
Ugt35A1	NP_524314.2	UDPGT	55..526	CDD:278624	139/494 (28%)
ugt1a6	NP_001107366.1	UDPGT	28..527	CDD:278624	146/521 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	248	1.000	Inparanoid score	I3175
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm9349
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.960