DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt35B1 and Ugt1a6a

DIOPT Version :9

Sequence 1:	NP_524313.2	Gene:	Ugt35B1 / 41333	FlyBaseID:	FBgn0026314	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_659545.2	Gene:	Ugt1a6a / 94284	MGIID:	2137698	Length:	531	Species:	Mus musculus

Alignment Length:	561	Identity:	173/561 - (30%)
Similarity:	272/561 - (48%)	Gaps:	90/561 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LRIGFLLLTLPASMQAARILAIFPFPGPSQYINVVPYLKELANRGHQVTSVNAFPQKKPVVNF-- 66
            |..|||.|.|.||:...::|.: |..| |.::::...::.|:.|||.:..:      .|.||.
Mouse    11 LPAGFLFLVLWASVLGDKLLVV-PQDG-SHWLSMKEIVEHLSERGHDIMVL------VPEVNLLL 67

  Fly    67 -------RDVF-----IPDVFNNYKELIN-------ELSGPMNLWQENNFINKFFVSVTRCVLTN 112
                   |.:|     :.::...::...|       .|.||:..::.|..:...|.|..:.:|.:
Mouse    68 GESKYYRRKIFSVTYSLEELQTRFRTFGNNHFLPGASLMGPLREYRNNMIVVDMFFSNCQSLLKD 132

  Fly   113 KEV-------------TETLLPPGKDHFDLIIVEALRSDAYYGFAAHFNAPIIGISTFGTDWNID 164
            ...             |:..:|.|     :|:.|.|...:.|.|.             |...:::
Mouse   133 SATLSFLRENKFDALFTDPAMPCG-----VILAEYLNLPSVYLFR-------------GFPCSLE 179

  Fly   165 ALVG-NESPLSYTPLATGGLTDRMTFLERLSNFVDTTVAWLNYRFVHMSEQEKMYAKYFPEAS-- 226
            .::| :.||:||.|......:|.|||.:||:||:...:.  ||.:.      .:|:||...||
Mouse   180 HMLGQSPSPVSYVPRFYTKFSDHMTFPQRLANFIVNILE--NYLYY------CLYSKYEIIASDL 236

  Fly   227 -KR-VQLTDLNRNFSLVLLNQHFSLSFPRPYVPNMIEVGGLHISHKPAPLPKDLEEFIQGSGEHG 289
             || |.|..|::| ||.||...|...:|||.:||||.:||::.. |...|.::.|.::..|||||
Mouse   237 LKRDVSLPSLHQN-SLWLLRYDFVFEYPRPVMPNMIFLGGINCK-KKGKLTQEFEAYVNASGEHG 299

  Fly   290 VIYFSLGSNVLSKDLPADRKDLILKTFASLPQRVLWKFEDDKLPGKPSNVFISKWFPQPDILAHP 354
            ::.|||||.|  .::|..:...|.:....:||.|||::...:......|..:.||.||.|:|.||
Mouse   300 IVVFSLGSMV--SEIPEKKAMEIAEALGRIPQTVLWRYTGTRPSNLAKNTILVKWLPQNDLLGHP 362

  Fly   355 KVKLFITHGGLLSTIESIHHGKPVLGLPFFYDQFLNVRRATQAGFGLGLDHTTMTQQELKETIEI 419
            |.:.||||.|.....|.|.:|.|::.:|.|.||..|.:|....|.|:.|:...||..:|:..::.
Mouse   363 KTRAFITHSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKT 427

  Fly   420 LLKEPRFAQIARQMSERYRDQPMSPLDTAIWWTEYVLRHKGAYHMRVAGQDLGFFAYHSLDVIGV 484
            ::....:.:...::|..::|:|:.|||.|::|.|||:|||||.|:|.|..||.::.||||||||.
Mouse   428 VINNKSYKENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHSLDVIGF 492

  Fly   485 LLGGALLLVAIIVGVL---------GKLTDFGNAKKKLKSK 516
            ||...|.:|.|:....         ||    |..||..|||
Mouse   493 LLAIVLTVVFIVFKCCAYGCRKCFGGK----GRVKKSHKSK 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35B1	NP_524313.2	egt	8..466	CDD:223071	146/496 (29%)
Ugt35B1	NP_524313.2	MGT	26..438	CDD:273616	123/450 (27%)
Ugt1a6a	NP_659545.2	egt	15..503	CDD:223071	162/525 (31%)
Ugt1a6a	NP_659545.2	UDPGT	27..522	CDD:278624	160/536 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840674
Domainoid	1	1.000	259	1.000	Domainoid score	I1975
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2975
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm42461
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.690