DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35B1 and Ugt2b35

DIOPT Version :9

Sequence 1:	NP_524313.2	Gene:	Ugt35B1 / 41333	FlyBaseID:	FBgn0026314	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_001004271.1	Gene:	Ugt2b35 / 83808	RGDID:	620895	Length:	530	Species:	Rattus norvegicus

Alignment Length:	548	Identity:	173/548 - (31%)
Similarity:	287/548 - (52%)	Gaps:	58/548 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLALRIGFLLLTLPASMQAARILAIFPFPGPSQYINVVPYLKELANRGHQVT----SVNAFPQKK 61
            :|.|:|.|..    .|....::| ::|.. .|.::|:...|:||..:||:||    |.:.|...|
  Rat     9 LLLLQISFCF----KSGNCGKVL-VWPME-YSHWMNIKIILEELVQKGHEVTVLRPSASVFLDPK 67

  Fly    62 PVVNFRDVFIPDVFNNYKELINELSGPMNLW----------------QEN-NFINKFFVSVTRCV 109
            ...:.:.|..|..|::: :|.|..:..:|:|                |:. :..:.:.::|.:..
  Rat    68 ETSDLKFVTFPTSFSSH-DLENFFTRFVNVWTYELPRDTCLSYFLYLQDTIDEYSDYCLTVCKEA 131

  Fly   110 LTNKEVTETLLPPGKDHFDLIIVEALRSDAYYG-----FAAHFNAPIIGISTFGTDWNIDALVGN 169
            ::||:.. |.|...|  ||::..:|:      |     .|.....|.:....|...:.|:..:|.
  Rat   132 VSNKQFM-TKLQESK--FDVVFSDAI------GPCGELIAELLQIPFLYSLRFSPGYTIEKYIGG 187

  Fly   170 E-SPLSYTPLATGGLTDRMTFLERLSNFVDTTVAWLNYRFVHMSEQEKMYAKYFPEASKR-VQLT 232
            . .|.||.|:...||..:|||:||:.|.    :..|.:.|...:.:||.:..::.:...| ..|.
  Rat   188 VLFPPSYVPMIFSGLAGQMTFIERVHNM----ICMLYFDFWFQTFREKKWDPFYSKTLGRPTTLA 248

  Fly   233 DLNRNFSLVLLNQHFSLSFPRPYVPNMIEVGGLHISHKPA-PLPKDLEEFIQGSGEHGVIYFSLG 296
            ::.....:.|:..::.|.||.|..||:..:||||.  ||| |||||:|:|:|.||||||:.||||
  Rat   249 EIMGKAEMWLIRSYWDLEFPHPISPNVDYIGGLHC--KPAKPLPKDIEDFVQSSGEHGVVVFSLG 311

  Fly   297 SNVLSKDLPADRKDLILKTFASLPQRVLWKFEDDKLPGKPSNVFISKWFPQPDILAHPKVKLFIT 361
            |.|  :::..::.::|....|.:||:|||:|:..|.|....|..:.||.||.|:|.|||.|.|:|
  Rat   312 SMV--RNMTEEKANIIAWALAQIPQKVLWRFDGKKPPTLGPNTRLYKWLPQNDLLGHPKTKAFVT 374

  Fly   362 HGGLLSTIESIHHGKPVLGLPFFYDQFLNVRRATQAGFGLGLDHTTMTQQELKETIEILLKEPRF 426
            |||.....|:||||.|::|:|.|.:|..|:......|..:.::..||::.::...:|.::..|.:
  Rat   375 HGGANGIYEAIHHGIPMIGIPLFGEQHDNIAHMVAKGAAVEVNFRTMSKSDMLNALEEVINNPFY 439

  Fly   427 AQIARQMSERYRDQPMSPLDTAIWWTEYVLRHKGAYHMRVAGQDLGFFAYHSLDVIGVLLGGALL 491
            .:.|..:|..:.|||..|||.|::|.|:|:|||||.|:|..|.:|.::.||||||||.||  ..:
  Rat   440 KKNAMWLSTIHHDQPTKPLDRAVFWIEFVMRHKGAKHLRSLGHNLPWYQYHSLDVIGFLL--TCV 502

  Fly   492 LVAIIVGV---LGKLTDFGNAKKKLKSK 516
            .|.:::.:   |.....|...:||.|::
  Rat   503 AVTVVLALKCFLFVYRFFVKKEKKTKNE 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35B1	NP_524313.2	egt	8..466	CDD:223071	151/486 (31%)
Ugt35B1	NP_524313.2	MGT	26..438	CDD:273616	132/440 (30%)
Ugt2b35	NP_001004271.1	UDPGT	24..527	CDD:278624	166/524 (32%)
Ugt2b35	NP_001004271.1	egt	<270..489	CDD:223071	93/222 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166344074
Domainoid	1	1.000	256	1.000	Domainoid score	I1959
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2882
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm9018
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.690