DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35B1 and UGT2A3

DIOPT Version :9

Sequence 1:	NP_524313.2	Gene:	Ugt35B1 / 41333	FlyBaseID:	FBgn0026314	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	XP_011530549.1	Gene:	UGT2A3 / 79799	HGNCID:	28528	Length:	533	Species:	Homo sapiens

Alignment Length:	496	Identity:	162/496 - (32%)
Similarity:	265/496 - (53%)	Gaps:	48/496 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 SQYINVVPYLKELANRGHQVTSV-----NAFPQKKP-VVNFRDVFIPDVFNNYKEL-----INEL 85
            |.::||...|:||..|||:||.:     :....:|| .:.|..|.:|.......|:     :|.|
Human    34 SHWLNVKVILEELIVRGHEVTVLTHSKPSLIDYRKPSALKFEVVHMPQDRTEENEIFVDLALNVL 98

  Fly    86 SGPMNLWQENNFINKFFVSV---TRCVLTNKEVTETLLPPGKD-HFDLIIVEAL--RSDAYYGFA 144
            .| ::.||....:|.|||.:   .:.:..:....:||:...:: ::|:::::.:  ..|.   .|
Human    99 PG-LSTWQSVIKLNDFFVEIRGTLKMMCESFIYNQTLMKKLQETNYDVMLIDPVIPCGDL---MA 159

  Fly   145 AHFNAPIIGISTFGTDWNIDALVGN-ESPLSYTPLATGGLTDRMTFLERLSNFVDTTV--AWL-- 204
            .....|.:.........|::...|. .:||||.|:...|||||||||||:.|.:.:.:  .|:
Human   160 ELLAVPFVLTLRISVGGNMERSCGKLPAPLSYVPVPMTGLTDRMTFLERVKNSMLSVLFHFWIQD 224

  Fly   205 -NYRFVHMSEQEKMYAKYFPEASKRVQLTDLNRNFSLVLLNQHFSLSFPRPYVPNMIEVGGLHIS 268
             :|.|     .|:.|:|   ...:...|.:......:.|:..::...||:||.||...|||||.
Human   225 YDYHF-----WEEFYSK---ALGRPTTLCETVGKAEIWLIRTYWDFEFPQPYQPNFEFVGGLHC- 280

  Fly   269 HKPA-PLPK------DLEEFIQGSGEHGVIYFSLGSNVLSKDLPADRKDLILKTFASLPQRVLWK 326
             ||| .|||      ::|.|:|.|||.|::.|||||  |.:::..::.::|....|.:||:|||:
Human   281 -KPAKALPKINFYLQEMENFVQSSGEDGIVVFSLGS--LFQNVTEEKANIIASALAQIPQKVLWR 342

  Fly   327 FEDDKLPGKPSNVFISKWFPQPDILAHPKVKLFITHGGLLSTIESIHHGKPVLGLPFFYDQFLNV 391
            ::..|.....:|..:..|.||.|:|.|||.|.||||||:....|:|:||.|::|:|.|.||..|:
Human   343 YKGKKPSTLGANTRLYDWIPQNDLLGHPKTKAFITHGGMNGIYEAIYHGVPMVGVPIFGDQLDNI 407

  Fly   392 RRATQAGFGLGLDHTTMTQQELKETIEILLKEPRFAQIARQMSERYRDQPMSPLDTAIWWTEYVL 456
            ......|..:.::..|||.::|...:..::.:..:.:.|.::|..:.|||:.|||.|::|.|:|:
Human   408 AHMKAKGAAVEINFKTMTSEDLLRALRTVITDSSYKENAMRLSRIHHDQPVKPLDRAVFWIEFVM 472

  Fly   457 RHKGAYHMRVAGQDLGFFAYHSLDVIGVLLGGALLLVAIIV 497
            |||||.|:|.|..||.:|.::|:||||.||  |.:..||.:
Human   473 RHKGAKHLRSAAHDLTWFQHYSIDVIGFLL--ACVATAIFL 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35B1	NP_524313.2	egt	8..466	CDD:223071	147/463 (32%)
Ugt35B1	NP_524313.2	MGT	26..438	CDD:273616	131/435 (30%)
UGT2A3	XP_011530549.1	UDPGT	24..528	CDD:278624	162/496 (33%)
UGT2A3	XP_011530549.1	egt	<267..498	CDD:223071	93/234 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150229
Domainoid	1	1.000	260	1.000	Domainoid score	I1978
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55988
Inparanoid	1	1.050	267	1.000	Inparanoid score	I3041
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm8543
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5436
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	12	11.720