DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35B1 and UGT2B17

DIOPT Version :9

Sequence 1:	NP_524313.2	Gene:	Ugt35B1 / 41333	FlyBaseID:	FBgn0026314	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_001068.1	Gene:	UGT2B17 / 7367	HGNCID:	12547	Length:	530	Species:	Homo sapiens

Alignment Length:	544	Identity:	170/544 - (31%)
Similarity:	274/544 - (50%)	Gaps:	62/544 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 FLLLTLPASMQAARILAIFPFPGP-SQYINVVPYLKELANRGHQV---TS-----VNA------- 56
            |||:.|.....:.....:..:|.. |.:||:...|:||..|||:|   ||     |||
Human     9 FLLMQLSCYFSSGSCGKVLVWPTEYSHWINMKTILEELVQRGHEVIVLTSSASILVNASKSSAIK 73

  Fly    57 ---FPQKKPVVNFRDVFI-----------PDVFNNYKELINELSGPMNLWQENNFINKFFVSVTR 107
               :|......:..|.|:           .:.|.:|...:.||     .|:.:::      ::..
Human    74 LEVYPTSLTKNDLEDFFMKMFDRWTYSISKNTFWSYFSQLQEL-----CWEYSDY------NIKL 127

  Fly   108 C--VLTNKEVTETLLPPGKDHFDLIIVEALRSDAYYGFAAHFNAPIIGISTFGTDWNIDALVGN- 169
            |  .:.||::...|   .:..||:::.:|:...... .|...|.|.:....|...:.::...|.
Human   128 CEDAVLNKKLMRKL---QESKFDVLLADAVNPCGEL-LAELLNIPFLYSLRFSVGYTVEKNGGGF 188

  Fly   170 ESPLSYTPLATGGLTDRMTFLERLSNFVDTTVAWLNYRFVHMSEQEKMYAKYFPEASKR-VQLTD 233
            ..|.||.|:....|:|:|.|:||:.|.    :..|.:.|...:...|.:.:::.|...| ..|.:
Human   189 LFPPSYVPVVMSELSDQMIFMERIKNM----IYMLYFDFWFQAYDLKKWDQFYSEVLGRPTTLFE 249

  Fly   234 LNRNFSLVLLNQHFSLSFPRPYVPNMIEVGGLHISHKPA-PLPKDLEEFIQGSGEHGVIYFSLGS 297
            ......:.|:..::...||||::||:..|||||.  ||| ||||::|||:|.|||:|::.|||||
Human   250 TMGKAEMWLIRTYWDFEFPRPFLPNVDFVGGLHC--KPAKPLPKEMEEFVQSSGENGIVVFSLGS 312

  Fly   298 NVLSKDLPADRKDLILKTFASLPQRVLWKFEDDKLPGKPSNVFISKWFPQPDILAHPKVKLFITH 362
            .:  .::..:..::|....|.:||:|||:|:..|.....||..:.||.||.|:|.|||.|.||||
Human   313 MI--SNMSEESANMIASALAQIPQKVLWRFDGKKPNTLGSNTRLYKWLPQNDLLGHPKTKAFITH 375

  Fly   363 GGLLSTIESIHHGKPVLGLPFFYDQFLNVRRATQAGFGLGLDHTTMTQQELKETIEILLKEPRFA 427
            ||.....|:|:||.|::|:|.|.||..|:......|..|.:|..||:.::|...::.::.:|.:.
Human   376 GGTNGIYEAIYHGIPMVGIPLFADQHDNIAHMKAKGAALSVDIRTMSSRDLLNALKSVINDPIYK 440

  Fly   428 QIARQMSERYRDQPMSPLDTAIWWTEYVLRHKGAYHMRVAGQDLGFFAYHSLDVIGVLLGGALLL 492
            :...::|..:.|||:.|||.|::|.|:|:|||||.|:|||..:|.:..|||||||..||.....:
Human   441 ENIMKLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHNLTWIQYHSLDVIAFLLACVATM 505

  Fly   493 VAII----VGVLGKLTDFGNAKKK 512
            :.:|    :....||...|..||:
Human   506 IFMITKCCLFCFRKLAKTGKKKKR 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35B1	NP_524313.2	egt	8..466	CDD:223071	151/492 (31%)
Ugt35B1	NP_524313.2	MGT	26..438	CDD:273616	131/446 (29%)
UGT2B17	NP_001068.1	UDPGT	24..518	CDD:278624	161/516 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150256
Domainoid	1	1.000	260	1.000	Domainoid score	I1978
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	267	1.000	Inparanoid score	I3041
Isobase	1	0.950	-	0	Normalized mean entropy	S5046
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm8543
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	10.640