Protein Alignment Ugt35B1 and UGT2B15

DIOPT Version :10

• Sequence 1: NP_524313.2
• Gene: Ugt35B1 / 41333
• FlyBaseID: FBgn0026314
• Length: 516
• Species: Drosophila melanogaster
• Sequence 2: NP_001067.2
• Gene: UGT2B15 / 7366
• HGNCID: 12546
• Length: 530
• Species: Homo sapiens
• Alignment Length: 540
• Identity: 177/540 - (32%)
• Similarity: 274/540 - (50%)
• Gaps: 52/540 - (9%)

  Fly     8 FLLLTLPASMQAARILAIFPFPGP-SQYINVVPYLKELANRGHQV--------TSVNAFPQKKPV 63
            |||:.|.....:.....:..:|.. |.:||:...|:||..|||:|        |.|||  .|...
Human     9 FLLIQLSCYFSSGSCGKVLVWPTEYSHWINMKTILEELVQRGHEVTVLTSSASTLVNA--SKSSA 71

  Fly    64 VNFRDVFIPDVFNNYKELINELSGPMNLW----QENNFINKFFVSVTRC-------------VLT 111
            :.. :|:...:..||.|  :.|...::.|    .:|.|.:.|......|             .:.
Human    72 IKL-EVYPTSLTKNYLE--DSLLKILDRWIYGVSKNTFWSYFSQLQELCWEYYDYSNKLCKDAVL 133

  Fly   112 NKEVTETLLPPGKDHFDLIIVEALRSDAYYGFAAHFNAPIIGISTFGTDWNIDALVGN-ESPLSY 175
            ||::   ::...:..||:|:.:||...... .|..||.|.:....|...:..:...|. ..|.||
Human   134 NKKL---MMKLQESKFDVILADALNPCGEL-LAELFNIPFLYSLRFSVGYTFEKNGGGFLFPPSY 194

  Fly   176 TPLATGGLTDRMTFLERLSNFVDTTVAWLNYRFVHMSEQEKMYAKYFPEASKR-VQLTDLNRNFS 239
            .|:....|:|:|.|:||:.|.:.    .|.:.|.......|.:.:::.|...| ..|.:......
Human   195 VPVVMSELSDQMIFMERIKNMIH----MLYFDFWFQIYDLKKWDQFYSEVLGRPTTLFETMGKAE 255

  Fly   240 LVLLNQHFSLSFPRPYVPNMIEVGGLHISHKPA-PLPKDLEEFIQGSGEHGVIYFSLGSNVLSKD 303
            :.|:..::...||||::||:..|||||.  ||| ||||::|||:|.|||:|::.|||||.:  .:
Human   256 MWLIRTYWDFEFPRPFLPNVDFVGGLHC--KPAKPLPKEMEEFVQSSGENGIVVFSLGSMI--SN 316

  Fly   304 LPADRKDLILKTFASLPQRVLWKFEDDKLPGKPSNVFISKWFPQPDILAHPKVKLFITHGGLLST 368
            :..:..::|....|.:||:|||:|:..|.....||..:.||.||.|:|.|||.|.||||||....
Human   317 MSEESANMIASALAQIPQKVLWRFDGKKPNTLGSNTRLYKWLPQNDLLGHPKTKAFITHGGTNGI 381

  Fly   369 IESIHHGKPVLGLPFFYDQFLNVRRATQAGFGLGLDHTTMTQQELKETIEILLKEPRFAQIARQM 433
            .|:|:||.|::|:|.|.||..|:......|..|.:|..||:.::|...::.::.:|.:.:...::
Human   382 YEAIYHGIPMVGIPLFADQHDNIAHMKAKGAALSVDIRTMSSRDLLNALKSVINDPVYKENVMKL 446

  Fly   434 SERYRDQPMSPLDTAIWWTEYVLRHKGAYHMRVAGQDLGFFAYHSLDVIGVLLGGALLLVAIIVG 498
            |..:.||||.|||.|::|.|:|:|||||.|:|||..:|.:..|||||||..||.    .||.::.
Human   447 SRIHHDQPMKPLDRAVFWIEFVMRHKGAKHLRVAAHNLTWIQYHSLDVIAFLLA----CVATVIF 507

  Fly   499 VLGK--LTDFGNAKKKLKSK 516
            ::.|  |..|....||.|.|
Human   508 IITKFCLFCFRKLAKKGKKK 527

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35B1	NP_524313.2	Glycosyltransferase_GTB-type	<171..482	CDD:471961	121/312 (39%)
UGT2B15	NP_001067.2	UDPGT	24..518	CDD:278624	168/514 (33%)