DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35B1 and UGT2A2

DIOPT Version :9

Sequence 1:	NP_524313.2	Gene:	Ugt35B1 / 41333	FlyBaseID:	FBgn0026314	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_001099147.2	Gene:	UGT2A2 / 574537	HGNCID:	28183	Length:	536	Species:	Homo sapiens

Alignment Length:	531	Identity:	182/531 - (34%)
Similarity:	275/531 - (51%)	Gaps:	44/531 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LTLPASMQAARILAIFPFPGPSQYINVVPYLKELANRGHQVT----SVNAFPQKKP--VVNFRDV 69
            |||...:.:..:| |:|..| |.::|:...|:||..|.|.||    |...|....|  .|||..:
Human    21 LTLTEVVLSGNVL-IWPTDG-SHWLNIKIILEELIQRNHNVTVLASSATLFINSNPDSPVNFEVI 83

  Fly    70 FIPDVFNNYKELINEL--------SGPMNLW----QENNFINKFF-VSVTRC--VLTNKEVTETL 119
            .:....:|...||..:        ..|:.:|    :....::.|| :::..|  ||.|.::...|
Human    84 PVSYKKSNIDSLIEHMIMLWIDHRPTPLTIWAFYKELGKLLDTFFQINIQLCDGVLKNPKLMARL 148

  Fly   120 LPPGKDHFDLIIVE--ALRSDAYYGFAAHFNAPIIGISTFGTDWNIDALVGN-ESPLSYTPLATG 181
            ...|   ||:::.:  .:..|.   .|.....|.:....|.....::...|. .:|:||.|.|..
Human   149 QKGG---FDVLVADPVTICGDL---VALKLGIPFMYTLRFSPASTVERHCGKIPAPVSYVPAALS 207

  Fly   182 GLTDRMTFLERLSNFVDTTVAWLNYRF-VHMSEQEKMYAKYFPEASKRVQLTDLNRNFSLVLLNQ 245
            .|||:|||.||:.|.:..::.  :|.| .:..|....|:|..   .:...|.:......:.|:..
Human   208 ELTDQMTFGERIKNTISYSLQ--DYIFQSYWGEWNSYYSKIL---GRPTTLCETMGKAEIWLIRT 267

  Fly   246 HFSLSFPRPYVPNMIEVGGLHISHKPA-PLPKDLEEFIQGSGEHGVIYFSLGSNVLSKDLPADRK 309
            ::...|||||:||...|||||.  ||| ||||::|||||.||::||:.|||||.|  |:|..::.
Human   268 YWDFEFPRPYLPNFEFVGGLHC--KPAKPLPKEMEEFIQSSGKNGVVVFSLGSMV--KNLTEEKA 328

  Fly   310 DLILKTFASLPQRVLWKFEDDKLPGKPSNVFISKWFPQPDILAHPKVKLFITHGGLLSTIESIHH 374
            :||....|.:||:|||:::..|.....:|..:..|.||.|:|.|||.|.||||||.....|:|:|
Human   329 NLIASALAQIPQKVLWRYKGKKPATLGNNTQLFDWIPQNDLLGHPKTKAFITHGGTNGIYEAIYH 393

  Fly   375 GKPVLGLPFFYDQFLNVRRATQAGFGLGLDHTTMTQQELKETIEILLKEPRFAQIARQMSERYRD 439
            |.|::|:|.|.||..|:......|..:.::..|||..:|...:..::.||.:.:.|.::|..:.|
Human   394 GVPMVGVPMFADQPDNIAHMKAKGAAVEVNLNTMTSVDLLSALRTVINEPSYKENAMRLSRIHHD 458

  Fly   440 QPMSPLDTAIWWTEYVLRHKGAYHMRVAGQDLGFFAYHSLDVIGVLLGGALLLVAIIVG-VLGKL 503
            ||:.|||.|::|.|:|:|||||.|:|||..||.:|.||||||||.||......:.:::. .|...
Human   459 QPVKPLDRAVFWIEFVMRHKGAKHLRVAAHDLTWFQYHSLDVIGFLLVCVTTAIFLVIQCCLFSC 523

  Fly   504 TDFGNAKKKLK 514
            ..||...||.|
Human   524 QKFGKIGKKKK 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35B1	NP_524313.2	egt	8..466	CDD:223071	160/480 (33%)
Ugt35B1	NP_524313.2	MGT	26..438	CDD:273616	139/437 (32%)
UGT2A2	NP_001099147.2	UDPGT	30..524	CDD:278624	174/510 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150175
Domainoid	1	1.000	260	1.000	Domainoid score	I1978
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	267	1.000	Inparanoid score	I3041
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm8543
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.690