DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35B1 and ugt5g1

DIOPT Version :9

Sequence 1:	NP_524313.2	Gene:	Ugt35B1 / 41333	FlyBaseID:	FBgn0026314	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_001107914.1	Gene:	ugt5g1 / 570913	ZFINID:	ZDB-GENE-080305-10	Length:	528	Species:	Danio rerio

Alignment Length:	540	Identity:	175/540 - (32%)
Similarity:	279/540 - (51%)	Gaps:	61/540 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LLTLPASMQAARILAIFPFPGPSQYINVVPYLKELANRGHQVTSVNA-----FPQKKPVVN---F 66
            ||::........|| :||..| |.::|:...|::|...||..|.|.:     ..:...:.|   .
Zfish    14 LLSVVCCCHGGNIL-VFPEDG-SHWVNMQVILRKLHTHGHSFTVVRSSKSWYIHENSALYNTITV 76

  Fly    67 RDVFIPDVFNNYKEL-------INELSGPMNLWQENNFINK----FFVSVTRCV---LTNKEVTE 117
            ..|...||..:|..:       :.::|..:..:::...|..    |...|.|.|   |.:.|:.:
Zfish    77 NPVETEDVGQDYFNMLLDRSLALQKMSPLVRFFEQQKDITTVLKVFHNGVLRMVSAMLDDAELVK 141

  Fly   118 TLLPPGKDHFDLIIVEALRSDAYYG--FAAHF-NAPIIGISTFGTDWNIDALVGNE-------SP 172
            :|   .:..|||::.:    .|:..  ..|:| ..|::        :|:..|...:       ||
Zfish   142 SL---REAKFDLLLTD----PAFPAGVLVANFLQLPMV--------YNVRWLNAGDAHMQTAPSP 191

  Fly   173 LSYTPLATGGLTDRMTFLERLSNFVDTTVAWLNYRFVHMSEQEKMYAKYFPEASKRVQLTDLNRN 237
            .||.|:....|.|:|:||:|:.||:....:.|..|:|.:....::..::||..|   .|..:.::
Zfish   192 PSYVPMYNSLLHDQMSFLQRVENFLRYLCSLLQERYVIVPIYRELLERHFPPGS---DLLSMQQS 253

  Fly   238 FSLVLLNQHFSLSFPRPYVPNMIEVGGLHISHKPA-PLPKDLEEFIQGSGEHGVIYFSLGSNVLS 301
            ..:.|:...|...||||.:||:|.:||...  ||| .||.|||||:|.||||||::.|||:.|.:
Zfish   254 ADIWLMRMDFVFDFPRPTMPNIIYMGGFQC--KPAQALPVDLEEFMQSSGEHGVVFMSLGAMVGA 316

  Fly   302 KDLPADRKDLILKTFASLPQRVLWKFEDDKLPGKPSNVFISKWFPQPDILAHPKVKLFITHGGLL 366
              ||....:.|...||.:||:|:|::..::.....:|..:.:||||.|:|.|||.:.|::|||..
Zfish   317 --LPRTITEAIASAFAKIPQKVMWRYHGERPSTLGNNTLLLEWFPQNDLLGHPKTRAFVSHGGTN 379

  Fly   367 STIESIHHGKPVLGLPFFYDQFLNVRRATQAGFGLGLDHTTMTQQELKETIEILLKEPRFAQIAR 431
            ...|:|:||.|||.||..:|||.||.|.........|...|:|.||..|.::.:|:.|.:....|
Zfish   380 GIYEAIYHGVPVLALPLLFDQFDNVMRLQVRNAARVLQVATLTSQEFLEGLKDVLENPLYRSSIR 444

  Fly   432 QMSERYRDQPMSPLDTAIWWTEYVLRHKGAYHMRVAGQDLGFFAYHSLDVIGVLLGGALLLVAII 496
            :|||.:||||:||||:|.:|.|||:|||||.|:|....:|.:::||||||:..||  |:.::|..
Zfish   445 KMSELHRDQPISPLDSATFWIEYVMRHKGAAHLRSEANNLAWYSYHSLDVLVFLL--AIAVIAFW 507

  Fly   497 VGVLGKLTDFGNAKKKLKSK 516
            ..|.  :..|...:|.:|.:
Zfish   508 TSVY--VCRFLCCRKSIKKR 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35B1	NP_524313.2	egt	8..466	CDD:223071	159/488 (33%)
Ugt35B1	NP_524313.2	MGT	26..438	CDD:273616	136/444 (31%)
ugt5g1	NP_001107914.1	UDPGT	24..526	CDD:278624	173/530 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584625
Domainoid	1	1.000	252	1.000	Domainoid score	I2043
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5436
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.820