DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt35B1 and ugt5c3

DIOPT Version :9

Sequence 1:	NP_524313.2	Gene:	Ugt35B1 / 41333	FlyBaseID:	FBgn0026314	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_001122186.1	Gene:	ugt5c3 / 563413	ZFINID:	ZDB-GENE-050419-23	Length:	531	Species:	Danio rerio

Alignment Length:	528	Identity:	156/528 - (29%)
Similarity:	259/528 - (49%)	Gaps:	80/528 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 GFLLLTLPASMQAARILAIFPFPGPSQYINVVPYLKELANRGHQVTSVN---------------- 55
            |||       ....:||.: |..| |.::|:...:|.|..:||.:..:.
Zfish    22 GFL-------CDGGKILVV-PLEG-SHWLNMDILIKALHGKGHSIDVIRNTNSWYVKEKSDYYNS 77

  Fly    56 -AFPQKKPVVNFRDVFIPDVFNNYKELINELSGPMNLWQ-----------ENNFINKFFVSVTRC 108
             ..||.|   ...:.|:.|:.:   ::||...|..: |.           :|..:.|....:|..
Zfish    78 ITIPQSK---GMDEEFVDDMIS---KVINHERGKSS-WLSTVKLFFDSVIDNYEMTKMVCDITTS 135

  Fly   109 VLTNKEVTETLLPPGKDHFDLIIVEALRSDAYYGFA---AH-FNAPII----GISTFGTDWNIDA 165
            :..::|:.:||   .:..:||::     :|..:|..   || ...|::    ..:|....:||
Zfish   136 IFESEEILKTL---QEKQYDLML-----TDPVWGMGIILAHKLKLPMVYNVRWTTTVDGHFNI-- 190

  Fly   166 LVGNESPLSYTPLATGGLTDRMTFLERLSNFVDTTVAWLNYRFVHMSEQEKMYAKYFPEASKRVQ 230
               ..||:||.|:...|.||||:|.:|:.|.:......:.|....:.:.:.:..|||   ...|.
Zfish   191 ---APSPMSYIPITGSGNTDRMSFFQRVKNIIFYFTNDIKYSRFSLPQYQAICDKYF---DPPVD 249

  Fly   231 LTDLNRNFSLVLLNQHFSLSFPRPYVPNMIEVGGLHISHKPA-PLPKDLEEFIQGSGEHGVIYFS 294
            ...|.:...:.|:...|...||||.:||:|..||...:  || |||.|||:|:|.||:||||..|
Zfish   250 FYQLLQGADIWLMRVDFVFEFPRPTMPNIIYTGGFQCT--PAKPLPHDLEDFMQSSGDHGVIVMS 312

  Fly   295 LGSNVLSKDLPADRKDLILKTFASLPQRVLWKFEDDKLPGKPSNVFISKWFPQPDILAHPKVKLF 359
            ||:.:.:  ||.|....|...||.|||:|:|::...|.....:|..:..|.||.|:|.|||.|:|
Zfish   313 LGTFISA--LPEDVTAEIAAAFARLPQKVIWRYTGKKPSTLGNNTLLVDWMPQKDLLGHPKTKVF 375

  Fly   360 ITHGGLLSTIESIHHGKPVLGLPFFYDQFLNVRRATQAGFGLGLDHTTMTQQELKETIEILLKEP 424
            :.|||.....|:::||.||:|:|||:||:.|:.|....|....:....:.:..|...|:.::..|
Zfish   376 VAHGGTNGVQEALYHGVPVVGIPFFFDQYDNLIRLQARGGAKIVSLAELGENSLHAAIKEVINNP 440

  Fly   425 RFAQIARQMSERYRDQPMSPLDTAIWWTEYVLRHKGAYHMRVAGQDLGFFAYHSLDVIGVLLGGA 489
            .:....:::|:.:.|:|:.|||:||:|.|:|:|||||.|:|.....:.:::|||:||       |
Zfish   441 SYRLTMQKLSQLHLDKPVKPLDSAIFWIEFVMRHKGAAHLRTESYKMPWYSYHSVDV-------A 498

  Fly   490 LLLVAIIV 497
            :.|:|:::
Zfish   499 VTLIAVVL 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35B1	NP_524313.2	egt	8..466	CDD:223071	146/494 (30%)
Ugt35B1	NP_524313.2	MGT	26..438	CDD:273616	126/448 (28%)
ugt5c3	NP_001122186.1	UDPGT	28..530	CDD:278624	153/515 (30%)
ugt5c3	NP_001122186.1	egt	<267..507	CDD:223071	97/251 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585086
Domainoid	1	1.000	252	1.000	Domainoid score	I2043
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.690