DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt35B1 and ugt5g2

DIOPT Version :9

Sequence 1:	NP_524313.2	Gene:	Ugt35B1 / 41333	FlyBaseID:	FBgn0026314	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_001186305.1	Gene:	ugt5g2 / 556049	ZFINID:	ZDB-GENE-081028-66	Length:	534	Species:	Danio rerio

Alignment Length:	535	Identity:	167/535 - (31%)
Similarity:	267/535 - (49%)	Gaps:	83/535 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LLLTLPASMQAARILAIFPFPGPSQYINVVPYLKELANRGHQVTSV----------NAFPQKKPV 63
            |||:||:...|.:|| :||..| |.::|:...:|:|.:|||:::.:          |:.......
Zfish    14 LLLSLPSGYNADKIL-VFPIDG-SHWVNMEVLVKKLQSRGHELSVIRLEDSWFIKGNSPYYSSIT 76

  Fly    64 VNFRDVFIP-DVFNN-YKELIN-ELSGPMN--LWQENNFI-------------------NKFFVS 104
            |..:..||. |:|.. .|:::: ...||:.  |.|.:.||                   ||..:|
Zfish    77 VTLKKKFIDLDLFETAVKKILDARRDGPIMGVLAQMSEFIGILKVGHGANIAMLTSMLENKVLMS 141

  Fly   105 VTRCVLTNKEVTETLLPPGKDHFDLIIVEALRSDAYYGF------AAHFN-APIIGISTFGTDWN 162
            ..:....:..:|:..:|.|     :|:...|.....|..      ..||: ||
Zfish   142 QIKMANYDLMLTDPAMPGG-----VILAHYLHLPMVYNVRWMSFGEGHFSIAP------------ 189

  Fly   163 IDALVGNESPLSYTPLATGGLTDRMTFLERLSNFVDTTVAWLNYRFVHMSEQEKMYAKYFPEASK 227
                    ||:|:.|:...||||||..|||..||:...:..:..|::.:.....:...:||..:
Zfish   190 --------SPISFVPVPGSGLTDRMGLLERSRNFLHYGLNLIQERWMVIPMYTSLLLNHFPPGT- 245

  Fly   228 RVQLTDLNRNFSLVLLNQHFSLSFPRPYVPNMIEVGGLHISHKPA-PLPKDLEEFIQGSGEHGVI 291
              .|..:.|:..|.|:...|...||||.:||::.:||...  :|| |||.|||||:|.||:|||:
Zfish   246 --DLLTMQRSAELWLVRADFVFEFPRPSMPNLVYIGGFQC--RPAKPLPADLEEFMQSSGDHGVV 306

  Fly   292 YFSLGSNVLSKDLPADRKDLILKTFASLPQRVLWKFEDDKLPGKPSNVFISKWFPQPDILAHPKV 356
            ..|||:  |...||.:..:.|...||.:||:|:|:|...:.....:|..:.:|.||.|:|.|||.
Zfish   307 VMSLGT--LIAGLPKEVMEAIASAFAQIPQKVIWRFIGQRPSTLGNNTLLIQWLPQNDLLGHPKT 369

  Fly   357 KLFITHGGLLSTIESIHHGKPVLGLPFFYDQFLNVRRATQAGFGLGLDHTTMTQQELKETIEILL 421
            :.|:.|||.....|:|:||.||||||..:||..|:.|....|....||..|.:.:|....:..:|
Zfish   370 RAFVAHGGTNGLYEAIYHGVPVLGLPLLFDQLDNIVRLQARGGARMLDAATCSTKEFLVALTDIL 434

  Fly   422 KEPRFAQIARQMSERYRDQPMSPLDTAIWWTEYVLRHKGAYHMRVAGQDLGFFAYHSLDVIGVLL 486
            :.|.:.|..:::|..:||:|:.|||.|::|.|:|||:|||.|:|....::..|:|:.|||:.
Zfish   435 ENPTYRQNMQKLSNLHRDRPLHPLDKAVYWIEFVLRNKGAPHLRAEAYNVSEFSYYCLDVVA--- 496

  Fly   487 GGALLLVAIIVGVLG 501
                |::.:::|.||
Zfish   497 ----LVLFMLLGTLG 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35B1	NP_524313.2	egt	8..466	CDD:223071	157/498 (32%)
Ugt35B1	NP_524313.2	MGT	26..438	CDD:273616	133/453 (29%)
ugt5g2	NP_001186305.1	egt	3..507	CDD:223071	165/533 (31%)
ugt5g2	NP_001186305.1	UDPGT	25..513	CDD:278624	161/524 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584626
Domainoid	1	1.000	252	1.000	Domainoid score	I2043
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.690