DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35B1 and UGT1A6

DIOPT Version :9

Sequence 1:	NP_524313.2	Gene:	Ugt35B1 / 41333	FlyBaseID:	FBgn0026314	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_001063.2	Gene:	UGT1A6 / 54578	HGNCID:	12538	Length:	532	Species:	Homo sapiens

Alignment Length:	561	Identity:	167/561 - (29%)
Similarity:	268/561 - (47%)	Gaps:	95/561 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 GFLLLTLPASMQAARILAIFPFPGPSQYINVVPYLKELANRGHQVTSVNAFPQKKPVVNF----- 66
            |...|.|...:...::|.: |..| |.::::...::.|::|||::..|      .|.||.
Human    14 GVFFLALWGMVVGDKLLVV-PQDG-SHWLSMKDIVEVLSDRGHEIVVV------VPEVNLLLKES 70

  Fly    67 ----RDVF-IP----DVFNNYKELINE-------LSGPMNLWQENNFINKFFVSVTRCVLTNKEV 115
                |.:: :|    ::.|.|:...|.       |:.|...::.|..:...:....:.:|.:::.
Human    71 KYYTRKIYPVPYDQEELKNRYQSFGNNHFAERSFLTAPQTEYRNNMIVIGLYFINCQSLLQDRDT 135

  Fly   116 -------------TETLLPPGKDHFDLIIVEALRSDAYY---GFAAHFNAPIIGISTFGTDWNID 164
                         |:..||.|     :|:.|.|...:.|   ||.....      .||..
Human   136 LNFFKESKFDALFTDPALPCG-----VILAEYLGLPSVYLFRGFPCSLE------HTFSR----- 184

  Fly   165 ALVGNESPLSYTPLATGGLTDRMTFLERLSNF-VDTTVAWLNYRFVHMSEQEKMYAKYFPEAS-- 226
                :..|:||.|......:|.|||.:|::|| |:....:|.|         .:::||...||
Human   185 ----SPDPVSYIPRCYTKFSDHMTFSQRVANFLVNLLEPYLFY---------CLFSKYEELASAV 236

  Fly   227 -KR-VQLTDLNRNFSLVLLNQHFSLSFPRPYVPNMIEVGGLHISHKPAPLPKDLEEFIQGSGEHG 289
             || |.:..|.:..|:.||...|.|.:|||.:|||:.:||::.. |...|.::.|.:|..|||||
Human   237 LKRDVDIITLYQKVSVWLLRYDFVLEYPRPVMPNMVFIGGINCK-KRKDLSQEFEAYINASGEHG 300

  Fly   290 VIYFSLGSNVLSKDLPADRKDLILKTFASLPQRVLWKFEDDKLPGKPSNVFISKWFPQPDILAHP 354
            ::.|||||.|  .::|..:...|......:||.|||::...:.....:|..:.||.||.|:|.||
Human   301 IVVFSLGSMV--SEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHP 363

  Fly   355 KVKLFITHGGLLSTIESIHHGKPVLGLPFFYDQFLNVRRATQAGFGLGLDHTTMTQQELKETIEI 419
            ..:.||||.|.....|||.:|.|::.:|.|.||..|.:|....|.|:.|:...||.::|:..::.
Human   364 MTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKA 428

  Fly   420 LLKEPRFAQIARQMSERYRDQPMSPLDTAIWWTEYVLRHKGAYHMRVAGQDLGFFAYHSLDVIGV 484
            ::.:..:.:...::|..::|:|:.|||.|::|.|:|:|||||.|:|.|..||.::.||||||||.
Human   429 VINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGF 493

  Fly   485 LLGGALLLVAIIV---------GVLGKLTDFGNAKKKLKSK 516
            || ..:|.||.|.         ..|||.   |..||..|||
Human   494 LL-AVVLTVAFITFKCCAYGYRKCLGKK---GRVKKAHKSK 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35B1	NP_524313.2	egt	8..466	CDD:223071	139/499 (28%)
Ugt35B1	NP_524313.2	MGT	26..438	CDD:273616	121/453 (27%)
UGT1A6	NP_001063.2	egt	15..506	CDD:223071	157/531 (30%)
UGT1A6	NP_001063.2	UDPGT	27..523	CDD:278624	159/539 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150646
Domainoid	1	1.000	260	1.000	Domainoid score	I1978
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	267	1.000	Inparanoid score	I3041
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm8543
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.690