Protein Alignment Ugt35B1 and UGT1A6

DIOPT Version :10

• Sequence 1: NP_524313.2
• Gene: Ugt35B1 / 41333
• FlyBaseID: FBgn0026314
• Length: 516
• Species: Drosophila melanogaster
• Sequence 2: NP_001063.2
• Gene: UGT1A6 / 54578
• HGNCID: 12538
• Length: 532
• Species: Homo sapiens
• Alignment Length: 561
• Identity: 167/561 - (29%)
• Similarity: 268/561 - (47%)
• Gaps: 95/561 - (16%)

  Fly     7 GFLLLTLPASMQAARILAIFPFPGPSQYINVVPYLKELANRGHQVTSVNAFPQKKPVVNF----- 66
            |...|.|...:...::|.: |..| |.::::...::.|::|||::..|      .|.||.
Human    14 GVFFLALWGMVVGDKLLVV-PQDG-SHWLSMKDIVEVLSDRGHEIVVV------VPEVNLLLKES 70

  Fly    67 ----RDVF-IP----DVFNNYKELINE-------LSGPMNLWQENNFINKFFVSVTRCVLTNKEV 115
                |.:: :|    ::.|.|:...|.       |:.|...::.|..:...:....:.:|.:::.
Human    71 KYYTRKIYPVPYDQEELKNRYQSFGNNHFAERSFLTAPQTEYRNNMIVIGLYFINCQSLLQDRDT 135

  Fly   116 -------------TETLLPPGKDHFDLIIVEALRSDAYY---GFAAHFNAPIIGISTFGTDWNID 164
                         |:..||.|     :|:.|.|...:.|   ||.....      .||..
Human   136 LNFFKESKFDALFTDPALPCG-----VILAEYLGLPSVYLFRGFPCSLE------HTFSR----- 184

  Fly   165 ALVGNESPLSYTPLATGGLTDRMTFLERLSNF-VDTTVAWLNYRFVHMSEQEKMYAKYFPEAS-- 226
                :..|:||.|......:|.|||.:|::|| |:....:|.|         .:::||...||
Human   185 ----SPDPVSYIPRCYTKFSDHMTFSQRVANFLVNLLEPYLFY---------CLFSKYEELASAV 236

  Fly   227 -KR-VQLTDLNRNFSLVLLNQHFSLSFPRPYVPNMIEVGGLHISHKPAPLPKDLEEFIQGSGEHG 289
             || |.:..|.:..|:.||...|.|.:|||.:|||:.:||::.. |...|.::.|.:|..|||||
Human   237 LKRDVDIITLYQKVSVWLLRYDFVLEYPRPVMPNMVFIGGINCK-KRKDLSQEFEAYINASGEHG 300

  Fly   290 VIYFSLGSNVLSKDLPADRKDLILKTFASLPQRVLWKFEDDKLPGKPSNVFISKWFPQPDILAHP 354
            ::.|||||.|  .::|..:...|......:||.|||::...:.....:|..:.||.||.|:|.||
Human   301 IVVFSLGSMV--SEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHP 363

  Fly   355 KVKLFITHGGLLSTIESIHHGKPVLGLPFFYDQFLNVRRATQAGFGLGLDHTTMTQQELKETIEI 419
            ..:.||||.|.....|||.:|.|::.:|.|.||..|.:|....|.|:.|:...||.::|:..::.
Human   364 MTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKA 428

  Fly   420 LLKEPRFAQIARQMSERYRDQPMSPLDTAIWWTEYVLRHKGAYHMRVAGQDLGFFAYHSLDVIGV 484
            ::.:..:.:...::|..::|:|:.|||.|::|.|:|:|||||.|:|.|..||.::.||||||||.
Human   429 VINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGF 493

  Fly   485 LLGGALLLVAIIV---------GVLGKLTDFGNAKKKLKSK 516
            || ..:|.||.|.         ..|||.   |..||..|||
Human   494 LL-AVVLTVAFITFKCCAYGYRKCLGKK---GRVKKAHKSK 530

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35B1	NP_524313.2	Glycosyltransferase_GTB-type	<171..482	CDD:471961	113/315 (36%)
UGT1A6	NP_001063.2	UDPGT	27..523	CDD:278624	159/539 (29%)