Protein Alignment Ugt35B1 and UGT1A7

DIOPT Version :10

• Sequence 1: NP_524313.2
• Gene: Ugt35B1 / 41333
• FlyBaseID: FBgn0026314
• Length: 516
• Species: Drosophila melanogaster
• Sequence 2: NP_061950.2
• Gene: UGT1A7 / 54577
• HGNCID: 12539
• Length: 530
• Species: Homo sapiens
• Alignment Length: 559
• Identity: 165/559 - (29%)
• Similarity: 261/559 - (46%)
• Gaps: 93/559 - (16%)

  Fly     8 FLLLTLPASMQAARILAIFPFPGPSQYINVVPYLKELANRGHQV--------------------- 51
            ::.|.|......|..|.:.|..| |.:..:...:::|..|||:|
Human    13 YVCLLLTCGFAKAGKLLVVPMDG-SHWFTMQSVVEKLILRGHEVVVVMPEVSWQLGRSLNCTVKT 76

  Fly    52 --TSVNAFPQKKPVVNFRDVFIPDVFNNYKELINELSGPMN-----LWQENNFINKFFVSVTRCV 109
              ||.....|.:..:.|.|.              ..:.|:.     |...:|.|...|.|..|.:
Human    77 YSTSYTLEDQDREFMVFADA--------------RWTAPLRSAFSLLTSSSNGIFDLFFSNCRSL 127

  Fly   110 LTNKEVTETLLPPGKDHFDLIIVEALRSDAYYGFAAHFNAPII----GISTFGTDWNIDALVGNE 170
            ..::::.|.|   .:..||.:.::...:.... .|.:|:.|.:    ||.....:.....    .
Human   128 FNDRKLVEYL---KESCFDAVFLDPFDACGLI-VAKYFSLPSVVFARGIFCHYLEEGAQC----P 184

  Fly   171 SPLSYTPLATGGLTDRMTFLERLSNFVDTTVAWLNYRFVHMSEQEKMYAKYFPE-----ASKRVQ 230
            :||||.|....|.:|.|||.||:.|.:           :|:  :|.::..||.:     ||:.:|
Human   185 APLSYVPRLLLGFSDAMTFKERVWNHI-----------MHL--EEHLFCPYFFKNVLEIASEILQ 236

  Fly   231 LT----DLNRNFSLVLLNQHFSLSFPRPYVPNMIEVGGLHISHKPAPLPKDLEEFIQGSGEHGVI 291
            ..    ||..:.|:.||...|.|.:|:|.:||||.:||:: .|:..|:|.:.|.:|..|||||::
Human   237 TPVTAYDLYSHTSIWLLRTDFVLEYPKPVMPNMIFIGGIN-CHQGKPVPMEFEAYINASGEHGIV 300

  Fly   292 YFSLGSNVLSKDLPADRKDLILKTFASLPQRVLWKFEDDKLPGKPSNVFISKWFPQPDILAHPKV 356
            .|||||.|  .::|..:...|......:||.|||::...:.....:|..:.||.||.|:|.||..
Human   301 VFSLGSMV--SEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMT 363

  Fly   357 KLFITHGGLLSTIESIHHGKPVLGLPFFYDQFLNVRRATQAGFGLGLDHTTMTQQELKETIEILL 421
            :.||||.|.....|||.:|.|::.:|.|.||..|.:|....|.|:.|:...||.::|:..::.::
Human   364 RAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVI 428

  Fly   422 KEPRFAQIARQMSERYRDQPMSPLDTAIWWTEYVLRHKGAYHMRVAGQDLGFFAYHSLDVIGVLL 486
            .:..:.:...::|..::|:|:.|||.|::|.|:|:|||||.|:|.|..||.::.||||||||.||
Human   429 NDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLL 493

  Fly   487 GGALLLVAIIV---------GVLGKLTDFGNAKKKLKSK 516
             ..:|.||.|.         ..|||.   |..||..|||
Human   494 -AVVLTVAFITFKCCAYGYRKCLGKK---GRVKKAHKSK 528

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35B1	NP_524313.2	Glycosyltransferase_GTB-type	<171..482	CDD:471961	114/319 (36%)
UGT1A7	NP_061950.2	UDPGT	26..521	CDD:278624	157/537 (29%)