DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35B1 and UGT1A7

DIOPT Version :9

Sequence 1:	NP_524313.2	Gene:	Ugt35B1 / 41333	FlyBaseID:	FBgn0026314	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_061950.2	Gene:	UGT1A7 / 54577	HGNCID:	12539	Length:	530	Species:	Homo sapiens

Alignment Length:	559	Identity:	165/559 - (29%)
Similarity:	261/559 - (46%)	Gaps:	93/559 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 FLLLTLPASMQAARILAIFPFPGPSQYINVVPYLKELANRGHQV--------------------- 51
            ::.|.|......|..|.:.|..| |.:..:...:::|..|||:|
Human    13 YVCLLLTCGFAKAGKLLVVPMDG-SHWFTMQSVVEKLILRGHEVVVVMPEVSWQLGRSLNCTVKT 76

  Fly    52 --TSVNAFPQKKPVVNFRDVFIPDVFNNYKELINELSGPMN-----LWQENNFINKFFVSVTRCV 109
              ||.....|.:..:.|.|.              ..:.|:.     |...:|.|...|.|..|.:
Human    77 YSTSYTLEDQDREFMVFADA--------------RWTAPLRSAFSLLTSSSNGIFDLFFSNCRSL 127

  Fly   110 LTNKEVTETLLPPGKDHFDLIIVEALRSDAYYGFAAHFNAPII----GISTFGTDWNIDALVGNE 170
            ..::::.|.|   .:..||.:.::...:.... .|.:|:.|.:    ||.....:.....    .
Human   128 FNDRKLVEYL---KESCFDAVFLDPFDACGLI-VAKYFSLPSVVFARGIFCHYLEEGAQC----P 184

  Fly   171 SPLSYTPLATGGLTDRMTFLERLSNFVDTTVAWLNYRFVHMSEQEKMYAKYFPE-----ASKRVQ 230
            :||||.|....|.:|.|||.||:.|.:           :|:  :|.::..||.:     ||:.:|
Human   185 APLSYVPRLLLGFSDAMTFKERVWNHI-----------MHL--EEHLFCPYFFKNVLEIASEILQ 236

  Fly   231 LT----DLNRNFSLVLLNQHFSLSFPRPYVPNMIEVGGLHISHKPAPLPKDLEEFIQGSGEHGVI 291
            ..    ||..:.|:.||...|.|.:|:|.:||||.:||:: .|:..|:|.:.|.:|..|||||::
Human   237 TPVTAYDLYSHTSIWLLRTDFVLEYPKPVMPNMIFIGGIN-CHQGKPVPMEFEAYINASGEHGIV 300

  Fly   292 YFSLGSNVLSKDLPADRKDLILKTFASLPQRVLWKFEDDKLPGKPSNVFISKWFPQPDILAHPKV 356
            .|||||.|  .::|..:...|......:||.|||::...:.....:|..:.||.||.|:|.||..
Human   301 VFSLGSMV--SEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMT 363

  Fly   357 KLFITHGGLLSTIESIHHGKPVLGLPFFYDQFLNVRRATQAGFGLGLDHTTMTQQELKETIEILL 421
            :.||||.|.....|||.:|.|::.:|.|.||..|.:|....|.|:.|:...||.::|:..::.::
Human   364 RAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVI 428

  Fly   422 KEPRFAQIARQMSERYRDQPMSPLDTAIWWTEYVLRHKGAYHMRVAGQDLGFFAYHSLDVIGVLL 486
            .:..:.:...::|..::|:|:.|||.|::|.|:|:|||||.|:|.|..||.::.||||||||.||
Human   429 NDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLL 493

  Fly   487 GGALLLVAIIV---------GVLGKLTDFGNAKKKLKSK 516
             ..:|.||.|.         ..|||.   |..||..|||
Human   494 -AVVLTVAFITFKCCAYGYRKCLGKK---GRVKKAHKSK 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35B1	NP_524313.2	egt	8..466	CDD:223071	138/498 (28%)
Ugt35B1	NP_524313.2	MGT	26..438	CDD:273616	119/452 (26%)
UGT1A7	NP_061950.2	UDPGT	26..521	CDD:278624	157/537 (29%)
UGT1A7	NP_061950.2	egt	<264..504	CDD:223071	95/243 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150345
Domainoid	1	1.000	260	1.000	Domainoid score	I1978
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	267	1.000	Inparanoid score	I3041
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm8543
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.690