Protein Alignment Ugt35B1 and UGT1A8

DIOPT Version :9

• Sequence 1: NP_524313.2
• Gene: Ugt35B1 / 41333
• FlyBaseID: FBgn0026314
• Length: 516
• Species: Drosophila melanogaster
• Sequence 2: NP_061949.3
• Gene: UGT1A8 / 54576
• HGNCID: 12540
• Length: 530
• Species: Homo sapiens
• Alignment Length: 553
• Identity: 170/553 - (30%)
• Similarity: 269/553 - (48%)
• Gaps: 85/553 - (15%)

  Fly     9 LLLTLPASMQAARILAIFPFPGPSQYINVVPYLKELANRGHQV---------------------- 51
            ||||. ...:|.::|.: |..| |.:..:...:::|..|||:|
Human    16 LLLTC-GFAEAGKLLVV-PMDG-SHWFTMQSVVEKLILRGHEVVVVMPEVSWQLGKSLNCTVKTY 77

  Fly    52 -TSVNAFPQKKPVVNFRDVFIPDVFNNYKELINELSGPMNLWQENNFINKFFVSVTRCVLTNKEV 115
             ||.......:..::|.|.       .:|..:..|.. :.|...|.|.|.|| |..|.:..::::
Human    78 STSYTLEDLDREFMDFADA-------QWKAQVRSLFS-LFLSSSNGFFNLFF-SHCRSLFNDRKL 133

  Fly   116 TETLLPPGKDHFDLIIVEALRSDAYYGFAAHFNAPII----GISTFGTDWNIDALVGNESPLSYT 176
            .|.|   .:..||.:.::...:.... .|.:|:.|.:    ||:....:.....    .:||||.
Human   134 VEYL---KESSFDAVFLDPFDACGLI-VAKYFSLPSVVFARGIACHYLEEGAQC----PAPLSYV 190

  Fly   177 PLATGGLTDRMTFLERLSNFVDTTVAWLNYRFVHMSEQEKMYAKYFPE-----ASKRVQLT---- 232
            |....|.:|.|||.||:.|.:           :|:  :|.::.:||.:     ||:.:|..
Human   191 PRILLGFSDAMTFKERVRNHI-----------MHL--EEHLFCQYFSKNALEIASEILQTPVTAY 242

  Fly   233 DLNRNFSLVLLNQHFSLSFPRPYVPNMIEVGGLHISHKPAPLPKDLEEFIQGSGEHGVIYFSLGS 297
            ||..:.|:.||...|.|.:|:|.:||||.:||:: .|:..|||.:.|.:|..|||||::.|||||
Human   243 DLYSHTSIWLLRTDFVLDYPKPVMPNMIFIGGIN-CHQGKPLPMEFEAYINASGEHGIVVFSLGS 306

  Fly   298 NVLSKDLPADRKDLILKTFASLPQRVLWKFEDDKLPGKPSNVFISKWFPQPDILAHPKVKLFITH 362
            .|  .::|..:...|......:||.|||::...:.....:|..:.||.||.|:|.||..:.||||
Human   307 MV--SEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITH 369

  Fly   363 GGLLSTIESIHHGKPVLGLPFFYDQFLNVRRATQAGFGLGLDHTTMTQQELKETIEILLKEPRFA 427
            .|.....|||.:|.|::.:|.|.||..|.:|....|.|:.|:...||.::|:..::.::.:..:.
Human   370 AGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYK 434

  Fly   428 QIARQMSERYRDQPMSPLDTAIWWTEYVLRHKGAYHMRVAGQDLGFFAYHSLDVIGVLLGGALLL 492
            :...::|..::|:|:.|||.|::|.|:|:|||||.|:|.|..||.::.||||||||.|| ..:|.
Human   435 ENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLL-AVVLT 498

  Fly   493 VAIIV---------GVLGKLTDFGNAKKKLKSK 516
            ||.|.         ..|||.   |..||..|||
Human   499 VAFITFKCCAYGYRKCLGKK---GRVKKAHKSK 528

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35B1	NP_524313.2	egt	8..466	CDD:223071	143/492 (29%)
		MGT	26..438	CDD:273616	122/447 (27%)
UGT1A8	NP_061949.3	UDPGT	26..521	CDD:278624	160/533 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150343
Domainoid	1	1.000	260	1.000	Domainoid score	I1978
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	267	1.000	Inparanoid score	I3041
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm8543
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.690